Large cell lung carcinoma with rhabdoid phenotype: Report of a rare entity presenting with chest wall involvement
Large cell lung carcinoma (LCLC), rhabdoid phenotype (RP) is a rare entity, accounting for 0.1-1% of all lung tumors. It is characterized by presence of more than 10% cells with rhabdoid morphology-large cells with abundant cytoplasm, eccentric nuclei, prominent nucleoli and eosinophilic cytoplasmic...
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| Veröffentlicht in: | Journal of cancer research and therapeutics 2015-07, Vol.11 (3), p.657 |
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| creator | Bahadur, Shalini Pujani, Mukta Jetley, Sujata Khetrapal, Shaan Raina, Prabhat Kumar |
| description | Large cell lung carcinoma (LCLC), rhabdoid phenotype (RP) is a rare entity, accounting for 0.1-1% of all lung tumors. It is characterized by presence of more than 10% cells with rhabdoid morphology-large cells with abundant cytoplasm, eccentric nuclei, prominent nucleoli and eosinophilic cytoplasmic inclusions. We report a case of rhabdoid variant of large cell carcinoma in a 65-year-old female. Patient presented with a lump in the right axilla. Computed tomography showed a large mass lesion in right lung with involvement of the chest wall. Tru-cut biopsy from the lung lesion was performed and histopathology was compatible with LCLC. A RP was considered due to the presence of tumor cells with eosinophilic cytoplasmic globules and eccentric nuclei. Cytokeratin and vimentin were diffusely positive while thyroid transcription factor was focally positive. INI-1, desmin, calretinin, HMB-45, and neuroendocrine markers were negative. This case highlights that recognition of large cell carcinoma lung, RP is very important because of its aggressive nature and adverse outcome. |
| doi_str_mv | 10.4103/0973-1482.138039 |
| format | Article |
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It is characterized by presence of more than 10% cells with rhabdoid morphology-large cells with abundant cytoplasm, eccentric nuclei, prominent nucleoli and eosinophilic cytoplasmic inclusions. We report a case of rhabdoid variant of large cell carcinoma in a 65-year-old female. Patient presented with a lump in the right axilla. Computed tomography showed a large mass lesion in right lung with involvement of the chest wall. Tru-cut biopsy from the lung lesion was performed and histopathology was compatible with LCLC. A RP was considered due to the presence of tumor cells with eosinophilic cytoplasmic globules and eccentric nuclei. Cytokeratin and vimentin were diffusely positive while thyroid transcription factor was focally positive. INI-1, desmin, calretinin, HMB-45, and neuroendocrine markers were negative. This case highlights that recognition of large cell carcinoma lung, RP is very important because of its aggressive nature and adverse outcome.</description><identifier>ISSN: 0973-1482</identifier><identifier>EISSN: 1998-4138</identifier><identifier>DOI: 10.4103/0973-1482.138039</identifier><identifier>PMID: 26458655</identifier><language>eng</language><publisher>India: Medknow Publications and Media Pvt. Ltd</publisher><subject>Aged ; Carcinoma, Large Cell - diagnostic imaging ; Care and treatment ; Case studies ; Diagnosis ; Female ; Humans ; Lung Neoplasms - diagnostic imaging ; Non-small cell lung cancer ; Patient outcomes ; Radiography ; Rhabdoid Tumor - diagnostic imaging ; Risk factors ; Thoracic Wall - diagnostic imaging ; Thoracic Wall - pathology</subject><ispartof>Journal of cancer research and therapeutics, 2015-07, Vol.11 (3), p.657</ispartof><rights>COPYRIGHT 2015 Medknow Publications and Media Pvt. 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It is characterized by presence of more than 10% cells with rhabdoid morphology-large cells with abundant cytoplasm, eccentric nuclei, prominent nucleoli and eosinophilic cytoplasmic inclusions. We report a case of rhabdoid variant of large cell carcinoma in a 65-year-old female. Patient presented with a lump in the right axilla. Computed tomography showed a large mass lesion in right lung with involvement of the chest wall. Tru-cut biopsy from the lung lesion was performed and histopathology was compatible with LCLC. A RP was considered due to the presence of tumor cells with eosinophilic cytoplasmic globules and eccentric nuclei. Cytokeratin and vimentin were diffusely positive while thyroid transcription factor was focally positive. INI-1, desmin, calretinin, HMB-45, and neuroendocrine markers were negative. 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| subjects | Aged Carcinoma, Large Cell - diagnostic imaging Care and treatment Case studies Diagnosis Female Humans Lung Neoplasms - diagnostic imaging Non-small cell lung cancer Patient outcomes Radiography Rhabdoid Tumor - diagnostic imaging Risk factors Thoracic Wall - diagnostic imaging Thoracic Wall - pathology |
| title | Large cell lung carcinoma with rhabdoid phenotype: Report of a rare entity presenting with chest wall involvement |
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