Phosphoinositide-Dependent Protein Kinase 1 (PDK1): Impact on Schizophrenia Risk and Endophenotype Profile
Phosphatidylinositol-3-kinase (PI3K) signaling influences susceptibility to virus infections, anoxia, obstetric complications, and cancer; which are changed in patients with schizophrenia and their first degree relatives. Therefore PI3K signaling might have impact on the pathophysiology of schizophr...
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| Veröffentlicht in: | Zeitschrift für Psychologie 2015-01, Vol.223 (3), p.165-172 |
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| container_title | Zeitschrift für Psychologie |
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| creator | Lang, Undine E. Ackermann, Teresa F. Wolfer, David Schubert, Florian Sohr, Reinhard Hörtnagl, Heide Lang, Florian Gallinat, Juergen |
| description | Phosphatidylinositol-3-kinase (PI3K) signaling influences
susceptibility to virus infections, anoxia, obstetric complications, and cancer;
which are changed in patients with schizophrenia and their first degree
relatives. Therefore PI3K signaling might have impact on the pathophysiology of
schizophrenia. PI3K signaling crucially involves phosphoinositide-dependent
protein kinase (PDK1). Increased anxiety behavior is observed in PDK1
hypomorphic mice. Here we show enhanced prevalence of schizophrenia in carriers
of the PDK1 CC genotype in human beings. Moreover, decreased parietal P300
amplitude, which is a well-studied schizophrenic endophenotype, was observed in
PDK1 CC carriers. Glutamate and glutamine concentrations are increased in the
frontal lobe of PDK1 dysmorphic mice and human CC individuals. Our results
demonstrate that the PDK1 CC genotype is associated with increased risk to
develop schizophrenia, a typical endophenotype profile observed in the disease
and modified neurotransmitter concentrations in brain regions associated with
the disease. |
| doi_str_mv | 10.1027/2151-2604/a000217 |
| format | Article |
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susceptibility to virus infections, anoxia, obstetric complications, and cancer;
which are changed in patients with schizophrenia and their first degree
relatives. Therefore PI3K signaling might have impact on the pathophysiology of
schizophrenia. PI3K signaling crucially involves phosphoinositide-dependent
protein kinase (PDK1). Increased anxiety behavior is observed in PDK1
hypomorphic mice. Here we show enhanced prevalence of schizophrenia in carriers
of the PDK1 CC genotype in human beings. Moreover, decreased parietal P300
amplitude, which is a well-studied schizophrenic endophenotype, was observed in
PDK1 CC carriers. Glutamate and glutamine concentrations are increased in the
frontal lobe of PDK1 dysmorphic mice and human CC individuals. Our results
demonstrate that the PDK1 CC genotype is associated with increased risk to
develop schizophrenia, a typical endophenotype profile observed in the disease
and modified neurotransmitter concentrations in brain regions associated with
the disease.</description><identifier>ISSN: 2190-8370</identifier><identifier>EISSN: 2151-2604</identifier><identifier>DOI: 10.1027/2151-2604/a000217</identifier><language>eng</language><publisher>Hogrefe Publishing</publisher><subject>Endophenotype ; Female ; Genotypes ; Human ; Kinases ; Male ; Mice ; Phenotypes ; Proteins ; Risk Factors ; Schizophrenia</subject><ispartof>Zeitschrift für Psychologie, 2015-01, Vol.223 (3), p.165-172</ispartof><rights>2015 Hogrefe Publishing</rights><rights>2015, Hogrefe Publishing</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-a262t-50cd7f1404be16102837f1ad357fa109c26544eaab45e01d6b496e2fb30967be3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27923,27924</link.rule.ids></links><search><creatorcontrib>Lang, Undine E.</creatorcontrib><creatorcontrib>Ackermann, Teresa F.</creatorcontrib><creatorcontrib>Wolfer, David</creatorcontrib><creatorcontrib>Schubert, Florian</creatorcontrib><creatorcontrib>Sohr, Reinhard</creatorcontrib><creatorcontrib>Hörtnagl, Heide</creatorcontrib><creatorcontrib>Lang, Florian</creatorcontrib><creatorcontrib>Gallinat, Juergen</creatorcontrib><title>Phosphoinositide-Dependent Protein Kinase 1 (PDK1): Impact on Schizophrenia Risk and Endophenotype Profile</title><title>Zeitschrift für Psychologie</title><description>Phosphatidylinositol-3-kinase (PI3K) signaling influences
susceptibility to virus infections, anoxia, obstetric complications, and cancer;
which are changed in patients with schizophrenia and their first degree
relatives. Therefore PI3K signaling might have impact on the pathophysiology of
schizophrenia. PI3K signaling crucially involves phosphoinositide-dependent
protein kinase (PDK1). Increased anxiety behavior is observed in PDK1
hypomorphic mice. Here we show enhanced prevalence of schizophrenia in carriers
of the PDK1 CC genotype in human beings. Moreover, decreased parietal P300
amplitude, which is a well-studied schizophrenic endophenotype, was observed in
PDK1 CC carriers. Glutamate and glutamine concentrations are increased in the
frontal lobe of PDK1 dysmorphic mice and human CC individuals. Our results
demonstrate that the PDK1 CC genotype is associated with increased risk to
develop schizophrenia, a typical endophenotype profile observed in the disease
and modified neurotransmitter concentrations in brain regions associated with
the disease.</description><subject>Endophenotype</subject><subject>Female</subject><subject>Genotypes</subject><subject>Human</subject><subject>Kinases</subject><subject>Male</subject><subject>Mice</subject><subject>Phenotypes</subject><subject>Proteins</subject><subject>Risk Factors</subject><subject>Schizophrenia</subject><issn>2190-8370</issn><issn>2151-2604</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2015</creationdate><recordtype>article</recordtype><recordid>eNo9kE9PwzAMxSMEEmPwAbhV4gISZbaTpvSINv5pk-gBzlHaulqn0ZakO4xPT6pNnGxZfn5-PyGuER4QKJ0RJhiTBjWzAECYnojJ_-x07DOIH2UK5-LC-w2AJtJyIihfd75fd03b-WZoKo4X3HNbcTtEuesGbtpo2bTWc4TRbb5Y4t2lOKvt1vPVsU7F18vz5_wtXn28vs-fVrElTUOcQFmlNSpQBaMOTwb3Gm0lk7S2CFlJOlGKrS1UwoCVLlSmmepCQqbTguVU3Bzu9q772bEfzKbbuTZYGkxDHiJQWdjCw1bpOu8d16Z3zbd1e4NgRjRmxGBGDOaIJmjuDxrbW9P7fWnd0JRb9uXOuZDc_Na9IZJGGtSJ_AP2-WNj</recordid><startdate>20150101</startdate><enddate>20150101</enddate><creator>Lang, Undine E.</creator><creator>Ackermann, Teresa F.</creator><creator>Wolfer, David</creator><creator>Schubert, Florian</creator><creator>Sohr, Reinhard</creator><creator>Hörtnagl, Heide</creator><creator>Lang, Florian</creator><creator>Gallinat, Juergen</creator><general>Hogrefe Publishing</general><scope>AAYXX</scope><scope>CITATION</scope><scope>7RZ</scope><scope>PSYQQ</scope></search><sort><creationdate>20150101</creationdate><title>Phosphoinositide-Dependent Protein Kinase 1 (PDK1)</title><author>Lang, Undine E. ; Ackermann, Teresa F. ; Wolfer, David ; Schubert, Florian ; Sohr, Reinhard ; Hörtnagl, Heide ; Lang, Florian ; Gallinat, Juergen</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-a262t-50cd7f1404be16102837f1ad357fa109c26544eaab45e01d6b496e2fb30967be3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2015</creationdate><topic>Endophenotype</topic><topic>Female</topic><topic>Genotypes</topic><topic>Human</topic><topic>Kinases</topic><topic>Male</topic><topic>Mice</topic><topic>Phenotypes</topic><topic>Proteins</topic><topic>Risk Factors</topic><topic>Schizophrenia</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Lang, Undine E.</creatorcontrib><creatorcontrib>Ackermann, Teresa F.</creatorcontrib><creatorcontrib>Wolfer, David</creatorcontrib><creatorcontrib>Schubert, Florian</creatorcontrib><creatorcontrib>Sohr, Reinhard</creatorcontrib><creatorcontrib>Hörtnagl, Heide</creatorcontrib><creatorcontrib>Lang, Florian</creatorcontrib><creatorcontrib>Gallinat, Juergen</creatorcontrib><collection>CrossRef</collection><collection>APA PsycArticles®</collection><collection>ProQuest One Psychology</collection><jtitle>Zeitschrift für Psychologie</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Lang, Undine E.</au><au>Ackermann, Teresa F.</au><au>Wolfer, David</au><au>Schubert, Florian</au><au>Sohr, Reinhard</au><au>Hörtnagl, Heide</au><au>Lang, Florian</au><au>Gallinat, Juergen</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Phosphoinositide-Dependent Protein Kinase 1 (PDK1): Impact on Schizophrenia Risk and Endophenotype Profile</atitle><jtitle>Zeitschrift für Psychologie</jtitle><date>2015-01-01</date><risdate>2015</risdate><volume>223</volume><issue>3</issue><spage>165</spage><epage>172</epage><pages>165-172</pages><issn>2190-8370</issn><eissn>2151-2604</eissn><abstract>Phosphatidylinositol-3-kinase (PI3K) signaling influences
susceptibility to virus infections, anoxia, obstetric complications, and cancer;
which are changed in patients with schizophrenia and their first degree
relatives. Therefore PI3K signaling might have impact on the pathophysiology of
schizophrenia. PI3K signaling crucially involves phosphoinositide-dependent
protein kinase (PDK1). Increased anxiety behavior is observed in PDK1
hypomorphic mice. Here we show enhanced prevalence of schizophrenia in carriers
of the PDK1 CC genotype in human beings. Moreover, decreased parietal P300
amplitude, which is a well-studied schizophrenic endophenotype, was observed in
PDK1 CC carriers. Glutamate and glutamine concentrations are increased in the
frontal lobe of PDK1 dysmorphic mice and human CC individuals. Our results
demonstrate that the PDK1 CC genotype is associated with increased risk to
develop schizophrenia, a typical endophenotype profile observed in the disease
and modified neurotransmitter concentrations in brain regions associated with
the disease.</abstract><pub>Hogrefe Publishing</pub><doi>10.1027/2151-2604/a000217</doi><tpages>8</tpages></addata></record> |
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| ispartof | Zeitschrift für Psychologie, 2015-01, Vol.223 (3), p.165-172 |
| issn | 2190-8370 2151-2604 |
| language | eng |
| recordid | cdi_proquest_journals_1721922049 |
| source | EBSCOhost APA PsycARTICLES; PsyJOURNALS |
| subjects | Endophenotype Female Genotypes Human Kinases Male Mice Phenotypes Proteins Risk Factors Schizophrenia |
| title | Phosphoinositide-Dependent Protein Kinase 1 (PDK1): Impact on Schizophrenia Risk and Endophenotype Profile |
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