HIV-1Nef promotes infection by excluding SERINC5 from virion incorporation

HIV-1 Nef, a protein important for the development of AIDS, has well-characterized effects on host membrane trafficking and receptor downregulation. By an unidentified mechanism, Nef increases the intrinsic infectivity of HIV-1 virions in a host-cell-dependent manner. Here we identify the host trans...

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Veröffentlicht in:	Nature (London) 2015-10, Vol.526 (7572), p.212
Hauptverfasser:	Rosa, Annachiara, Chande, Ajit, Ziglio, Serena, De Sanctis, Veronica, Bertorelli, Roberto, Goh, Shih Lin, McCauley, Sean M, Nowosielska, Anetta, Antonarakis, Stylianos E, Luban, Jeremy, Santoni, Federico Andrea, Pizzato, Massimo
Format:	Artikel
Sprache:	eng
Schlagworte:	Cells Genes HIV Human immunodeficiency virus Infections Kinases Leukemia Membranes Proteins
Online-Zugang:	Volltext
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