Dual properties of hispidulin: antiproliferative effects on HepG2 cancer cells and selective inhibition of ABCG2 transport activity

Hepatocellular carcinoma is the third most common cause of cancer-related deaths worldwide. Furthermore, the existing pharmacological-based treatments are insufficiently effective and generate many side effects. Hispidulin (6-methoxy-5,7,4′-trihydroxyflavone) is a flavonoid found in various medicina...

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Veröffentlicht in:	Molecular and cellular biochemistry 2015-11, Vol.409 (1-2), p.123-133
Hauptverfasser:	Scoparo, Carina T., Valdameri, Glaucio, Worfel, Paulo R., Guterres, Fernanda A. L. B., Martinez, Glaucia R., Winnischofer, Sheila M. B., Di Pietro, Attilio, Rocha, Maria E. M.
Format:	Artikel
Sprache:	eng
Schlagworte:	Acetylcysteine Analysis Animals Antioxidants Antioxidants - pharmacology Apoptosis - drug effects ATP Binding Cassette Transporter, Sub-Family G, Member 2 ATP-Binding Cassette Transporters - antagonists & inhibitors Biochemistry Bioflavonoids Biological Transport - drug effects Biomedical and Life Sciences Cancer Cancer cells Carcinoma, Hepatocellular - drug therapy Carcinoma, Hepatocellular - pathology Cardiology Catalase - biosynthesis Catalase - genetics Cell Line, Tumor Cell Proliferation - drug effects Cell Survival - drug effects Cellular biology Drug resistance Enzymatic activity Enzymes Flavones Flavones - pharmacology Flavonoids Glutathione - metabolism Health aspects HEK293 Cells Hep G2 Cells Herbal medicine Humans Hydrogen peroxide L Cells (Cell Line) Life Sciences Liver Neoplasms - drug therapy Liver Neoplasms - pathology Medical Biochemistry Mice Mitoxantrone - metabolism Multidrug Resistance-Associated Proteins - biosynthesis Oncology Plants, Medicinal - metabolism Prevention Reactive Oxygen Species - metabolism RNA RNA, Messenger - biosynthesis Side effects
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