Correlation between peripapillary retinal thickness and serum level of vascular endothelial growth factor in patients with POEMS syndrome

Correlation between peripapillary retinal thickness and serum level of vascular endothelial growth factor in patients with POEMS syndrome

Purpose To determine whether there is a significant correlation between the peripapillary retinal thickness (pRT) and the serum level of vascular endothelial growth factor (VEGF) in patients with polyneuropathy, organomegaly, endocrinopathy, monoclonal gammopathy, and skin changes (POEMS) syndrome....

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Veröffentlicht in:Acta ophthalmologica (Oxford, England) England), 2015-10, Vol.93 (S255), p.n/a
Hauptverfasser: Yokouchi, H., Baba, T., Oshitari, T., Yamamoto, S.
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Baba, T.
Oshitari, T.
Yamamoto, S.
description Purpose To determine whether there is a significant correlation between the peripapillary retinal thickness (pRT) and the serum level of vascular endothelial growth factor (VEGF) in patients with polyneuropathy, organomegaly, endocrinopathy, monoclonal gammopathy, and skin changes (POEMS) syndrome. Methods This was a cross sectional, observational case series. We studied 34 eyes of 17 treatment‐naïve patients with POEMS syndrome whose intracranial pressure (ICP) was within the normal range. The spectral‐domain optical coherence tomographic (SD‐OCT) examinations consisted of circle scans around the optic disc (3.45 mm in diameter). The pRT was automatically measured in the SD‐OCT images, and the average pRT was used for the statistical analysis. The serum level of VEGF was measured by Enzyme‐linked immunosorbent assays (ELISAs), and the correlation between the pRT and the serum level of VEGF was determined. Results The mean serum level of VEGF in all POEMS patients was 6085 ± 3332 pg/ml with a range of 1380 to 12000 pg/ml. The correlation between the pRT and the serum level of VEGF was significant (right eye, r = 0.85, P 
doi_str_mv 10.1111/j.1755-3768.2015.0321
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Methods This was a cross sectional, observational case series. We studied 34 eyes of 17 treatment‐naïve patients with POEMS syndrome whose intracranial pressure (ICP) was within the normal range. The spectral‐domain optical coherence tomographic (SD‐OCT) examinations consisted of circle scans around the optic disc (3.45 mm in diameter). The pRT was automatically measured in the SD‐OCT images, and the average pRT was used for the statistical analysis. The serum level of VEGF was measured by Enzyme‐linked immunosorbent assays (ELISAs), and the correlation between the pRT and the serum level of VEGF was determined. Results The mean serum level of VEGF in all POEMS patients was 6085 ± 3332 pg/ml with a range of 1380 to 12000 pg/ml. The correlation between the pRT and the serum level of VEGF was significant (right eye, r = 0.85, P &lt; 0.0001; left eye, r = 0.65, P = 0.004, Spearman's rank‐correlation coefficient), and there was a strong positive correlation between the pRT of the right eyes and left eyes (r = 0.83, P &lt; 0.0001, Spearman's rank‐correlation coefficient). Conclusions The significant correlation between the pRT and the serum level of VEGF suggests that the higher serum level of VEGF might be associated with the development of the optic disc edema in patients with POEMS syndrome.</description><identifier>ISSN: 1755-375X</identifier><identifier>EISSN: 1755-3768</identifier><identifier>DOI: 10.1111/j.1755-3768.2015.0321</identifier><language>eng</language><publisher>Malden: Wiley Subscription Services, Inc</publisher><subject>Ophthalmology</subject><ispartof>Acta ophthalmologica (Oxford, England), 2015-10, Vol.93 (S255), p.n/a</ispartof><rights>2015 Acta Ophthalmologica Scandinavica Foundation. 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Methods This was a cross sectional, observational case series. We studied 34 eyes of 17 treatment‐naïve patients with POEMS syndrome whose intracranial pressure (ICP) was within the normal range. The spectral‐domain optical coherence tomographic (SD‐OCT) examinations consisted of circle scans around the optic disc (3.45 mm in diameter). The pRT was automatically measured in the SD‐OCT images, and the average pRT was used for the statistical analysis. The serum level of VEGF was measured by Enzyme‐linked immunosorbent assays (ELISAs), and the correlation between the pRT and the serum level of VEGF was determined. Results The mean serum level of VEGF in all POEMS patients was 6085 ± 3332 pg/ml with a range of 1380 to 12000 pg/ml. The correlation between the pRT and the serum level of VEGF was significant (right eye, r = 0.85, P &lt; 0.0001; left eye, r = 0.65, P = 0.004, Spearman's rank‐correlation coefficient), and there was a strong positive correlation between the pRT of the right eyes and left eyes (r = 0.83, P &lt; 0.0001, Spearman's rank‐correlation coefficient). Conclusions The significant correlation between the pRT and the serum level of VEGF suggests that the higher serum level of VEGF might be associated with the development of the optic disc edema in patients with POEMS syndrome.</description><subject>Ophthalmology</subject><issn>1755-375X</issn><issn>1755-3768</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2015</creationdate><recordtype>article</recordtype><recordid>eNqNkNtKAzEQhhdRsFYfQQh43ZrJNrupd6XUA1QqVMG7sIdZm5pu1iTb0kfwrc1a6bW5mTD83wzzRdE10CGEd7seQsr5IE4TMWQU-JDGDE6i3rF7evzz9_Powrk1pQkkyagXfU-Ntagzr0xNcvQ7xJo0aFWTNUrrzO6JRa_qTBO_UsVnjc6RrC6JQ9tuiMYtamIqss1c0YY4wbo0foVaBeLDmp1fkSorvLFEhcFhD9bekZ0K_ZfF7HlJ3L4urdngZXRWZdrh1V_tR2_3s9fp42C-eHiaTuaDAlIGg_GIC87EuBQQj0SRIIeKIRc5q3IUrMIqTwQwhjlN-AjLtKSQl7SkohhDPM7jfnRzmNtY89Wi83JtWhsOdBJS4ClPgNOQ4odUYY1zFivZWLUJOiRQ2VmXa9k5lZ1f2VmXnfXA3R24ndK4_x8kJ4vlL_wDQE6Jbg</recordid><startdate>201510</startdate><enddate>201510</enddate><creator>Yokouchi, H.</creator><creator>Baba, T.</creator><creator>Oshitari, T.</creator><creator>Yamamoto, S.</creator><general>Wiley Subscription Services, Inc</general><scope>AAYXX</scope><scope>CITATION</scope><scope>7TK</scope></search><sort><creationdate>201510</creationdate><title>Correlation between peripapillary retinal thickness and serum level of vascular endothelial growth factor in patients with POEMS syndrome</title><author>Yokouchi, H. ; Baba, T. ; Oshitari, T. ; Yamamoto, S.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c1721-94585289d81348c6e51f2e58b2fbe82fefb68122eb0654ed7d01bd0d08c9139b3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2015</creationdate><topic>Ophthalmology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Yokouchi, H.</creatorcontrib><creatorcontrib>Baba, T.</creatorcontrib><creatorcontrib>Oshitari, T.</creatorcontrib><creatorcontrib>Yamamoto, S.</creatorcontrib><collection>CrossRef</collection><collection>Neurosciences Abstracts</collection><jtitle>Acta ophthalmologica (Oxford, England)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Yokouchi, H.</au><au>Baba, T.</au><au>Oshitari, T.</au><au>Yamamoto, S.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Correlation between peripapillary retinal thickness and serum level of vascular endothelial growth factor in patients with POEMS syndrome</atitle><jtitle>Acta ophthalmologica (Oxford, England)</jtitle><date>2015-10</date><risdate>2015</risdate><volume>93</volume><issue>S255</issue><epage>n/a</epage><issn>1755-375X</issn><eissn>1755-3768</eissn><abstract>Purpose To determine whether there is a significant correlation between the peripapillary retinal thickness (pRT) and the serum level of vascular endothelial growth factor (VEGF) in patients with polyneuropathy, organomegaly, endocrinopathy, monoclonal gammopathy, and skin changes (POEMS) syndrome. Methods This was a cross sectional, observational case series. We studied 34 eyes of 17 treatment‐naïve patients with POEMS syndrome whose intracranial pressure (ICP) was within the normal range. The spectral‐domain optical coherence tomographic (SD‐OCT) examinations consisted of circle scans around the optic disc (3.45 mm in diameter). The pRT was automatically measured in the SD‐OCT images, and the average pRT was used for the statistical analysis. The serum level of VEGF was measured by Enzyme‐linked immunosorbent assays (ELISAs), and the correlation between the pRT and the serum level of VEGF was determined. Results The mean serum level of VEGF in all POEMS patients was 6085 ± 3332 pg/ml with a range of 1380 to 12000 pg/ml. The correlation between the pRT and the serum level of VEGF was significant (right eye, r = 0.85, P &lt; 0.0001; left eye, r = 0.65, P = 0.004, Spearman's rank‐correlation coefficient), and there was a strong positive correlation between the pRT of the right eyes and left eyes (r = 0.83, P &lt; 0.0001, Spearman's rank‐correlation coefficient). Conclusions The significant correlation between the pRT and the serum level of VEGF suggests that the higher serum level of VEGF might be associated with the development of the optic disc edema in patients with POEMS syndrome.</abstract><cop>Malden</cop><pub>Wiley Subscription Services, Inc</pub><doi>10.1111/j.1755-3768.2015.0321</doi><tpages>1</tpages><oa>free_for_read</oa></addata></record>
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title Correlation between peripapillary retinal thickness and serum level of vascular endothelial growth factor in patients with POEMS syndrome
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