Glucose uptake through translocation and activation of GLUT4 in PI3K/Akt signaling pathway by asiatic acid in diabetic rats

In this study, we examined the in vivo effect and the mechanism of asiatic acid (AA) on glucose uptake in an insulin target skeletal muscle. Diabetic rats showed significantly increased levels of plasma glucose, thiobarbituric acid reactive substances, and lipid hydroperoxides, decreased levels of i...

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Veröffentlicht in:	Human & experimental toxicology 2015-09, Vol.34 (9), p.884-893
Hauptverfasser:	Ramachandran, V, Saravanan, R
Format:	Artikel
Sprache:	eng
Schlagworte:	Acids Animals Antioxidants - metabolism Diabetes Diabetes Mellitus, Experimental - blood Diabetes Mellitus, Experimental - metabolism Glucose Glucose - metabolism Glucose Transporter Type 4 - drug effects Glucose Transporter Type 4 - metabolism Insulin Insulin - blood Lipid Peroxidation - drug effects Male Oncogene Protein v-akt - drug effects Oncogene Protein v-akt - metabolism Pentacyclic Triterpenes - pharmacology Phosphatidylinositol 3-Kinases - drug effects Phosphatidylinositol 3-Kinases - metabolism Rats Rats, Wistar Receptor, Insulin - biosynthesis Rodents Signal Transduction - drug effects Studies Thiobarbituric Acid Reactive Substances - metabolism
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