Childhood extracranial neoplasms: the role of imaging in drug development and clinical trials
Cancer is the leading cause of death in children older than 1 year of age and new drugs are necessary to improve outcomes. Imaging is crucial to the drug development process and assessment of therapeutic response. In adults, tumours are often assessed with CT using size criteria. Unfortunately, tech...
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| Veröffentlicht in: | Pediatric radiology 2015-10, Vol.45 (11), p.1600-1615 |
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| container_title | Pediatric radiology |
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| creator | Fowkes, Lucy A. Koh, Dow-Mu Collins, David J. Jerome, Neil P. MacVicar, David Chua, Sue C. Pearson, Andrew D. J. |
| description | Cancer is the leading cause of death in children older than 1 year of age and new drugs are necessary to improve outcomes. Imaging is crucial to the drug development process and assessment of therapeutic response. In adults, tumours are often assessed with CT using size criteria. Unfortunately, techniques established in adults are not necessarily applicable in children due to differing pathophysiology, ability to cooperate and increased susceptibility to ionising radiation. MRI, in particular quantitative MRI, has to date not been fully utilised in children with extracranial neoplasms. The specific challenges of imaging in children, the potential for functional imaging techniques to inform upon and their inclusion in clinical trials are discussed. |
| doi_str_mv | 10.1007/s00247-015-3342-8 |
| format | Article |
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The specific challenges of imaging in children, the potential for functional imaging techniques to inform upon and their inclusion in clinical trials are discussed.</description><identifier>ISSN: 0301-0449</identifier><identifier>EISSN: 1432-1998</identifier><identifier>DOI: 10.1007/s00247-015-3342-8</identifier><identifier>PMID: 26045035</identifier><language>eng</language><publisher>Berlin/Heidelberg: Springer Berlin Heidelberg</publisher><subject>Adolescent ; Child ; Child, Preschool ; Clinical Trials as Topic - methods ; Drug Design ; Drug Monitoring - methods ; Female ; Humans ; Imaging ; Infant ; Infant, Newborn ; Magnetic Resonance Imaging - methods ; Male ; Medicine ; Medicine & Public Health ; Neoplasms - diagnosis ; Neoplasms - drug therapy ; Neuroradiology ; Nuclear Medicine ; Oncology ; Pediatrics ; Radiology ; Review ; Tomography, X-Ray Computed - methods ; Treatment Outcome ; Ultrasound</subject><ispartof>Pediatric radiology, 2015-10, Vol.45 (11), p.1600-1615</ispartof><rights>Springer-Verlag Berlin Heidelberg 2015</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c442t-69962ab40fde2c372acb71a76fac3fd07762cbfce5c477c34553f21958b53e0d3</citedby><cites>FETCH-LOGICAL-c442t-69962ab40fde2c372acb71a76fac3fd07762cbfce5c477c34553f21958b53e0d3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s00247-015-3342-8$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s00247-015-3342-8$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>313,314,780,784,792,27922,27924,27925,41488,42557,51319</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/26045035$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Fowkes, Lucy A.</creatorcontrib><creatorcontrib>Koh, Dow-Mu</creatorcontrib><creatorcontrib>Collins, David J.</creatorcontrib><creatorcontrib>Jerome, Neil P.</creatorcontrib><creatorcontrib>MacVicar, David</creatorcontrib><creatorcontrib>Chua, Sue C.</creatorcontrib><creatorcontrib>Pearson, Andrew D. J.</creatorcontrib><title>Childhood extracranial neoplasms: the role of imaging in drug development and clinical trials</title><title>Pediatric radiology</title><addtitle>Pediatr Radiol</addtitle><addtitle>Pediatr Radiol</addtitle><description>Cancer is the leading cause of death in children older than 1 year of age and new drugs are necessary to improve outcomes. Imaging is crucial to the drug development process and assessment of therapeutic response. In adults, tumours are often assessed with CT using size criteria. Unfortunately, techniques established in adults are not necessarily applicable in children due to differing pathophysiology, ability to cooperate and increased susceptibility to ionising radiation. MRI, in particular quantitative MRI, has to date not been fully utilised in children with extracranial neoplasms. 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| fulltext | fulltext |
| identifier | ISSN: 0301-0449 |
| ispartof | Pediatric radiology, 2015-10, Vol.45 (11), p.1600-1615 |
| issn | 0301-0449 1432-1998 |
| language | eng |
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| source | MEDLINE; SpringerNature Journals |
| subjects | Adolescent Child Child, Preschool Clinical Trials as Topic - methods Drug Design Drug Monitoring - methods Female Humans Imaging Infant Infant, Newborn Magnetic Resonance Imaging - methods Male Medicine Medicine & Public Health Neoplasms - diagnosis Neoplasms - drug therapy Neuroradiology Nuclear Medicine Oncology Pediatrics Radiology Review Tomography, X-Ray Computed - methods Treatment Outcome Ultrasound |
| title | Childhood extracranial neoplasms: the role of imaging in drug development and clinical trials |
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