Phase I trial of afatinib plus vinorelbine in Japanese patients with advanced solid tumors, including breast cancer

Purpose This phase I trial assessed afatinib, an irreversible ErbB family blocker, plus vinorelbine in Japanese patients with advanced solid tumors not amenable to standard treatment. Methods Primary objectives were evaluation of safety and the maximum tolerated dose (MTD) of once-daily (QD) afatini...

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Veröffentlicht in:	Cancer chemotherapy and pharmacology 2015-10, Vol.76 (4), p.739-750
Hauptverfasser:	Mukai, Hirofumi, Masuda, Norikazu, Ishiguro, Hiroshi, Mitsuma, Ayako, Shibata, Takashi, Yamamura, Jun, Toi, Masakazu, Watabe, Aiko, Sarashina, Akiko, Uttenreuther-Fischer, Martina, Ando, Yuichi
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Aged Antineoplastic Agents - administration & dosage Antineoplastic Agents - adverse effects Antineoplastic Agents - pharmacokinetics Antineoplastic Agents - therapeutic use Antineoplastic Agents, Phytogenic - administration & dosage Antineoplastic Agents, Phytogenic - adverse effects Antineoplastic Agents, Phytogenic - pharmacokinetics Antineoplastic Agents, Phytogenic - therapeutic use Antineoplastic Combined Chemotherapy Protocols - administration & dosage Antineoplastic Combined Chemotherapy Protocols - adverse effects Antineoplastic Combined Chemotherapy Protocols - pharmacokinetics Antineoplastic Combined Chemotherapy Protocols - therapeutic use Breast Neoplasms - blood Breast Neoplasms - drug therapy Breast Neoplasms - pathology Cancer Research Cohort Studies Dose-Response Relationship, Drug Drug Monitoring ErbB Receptors - antagonists & inhibitors Female Humans Japan Leukopenia - chemically induced Male Medicine Medicine & Public Health Middle Aged Neoplasms - blood Neoplasms - drug therapy Neoplasms - pathology Oncology Original Article Patient Dropouts Pharmacology/Toxicology Protein Kinase Inhibitors - administration & dosage Protein Kinase Inhibitors - adverse effects Protein Kinase Inhibitors - pharmacokinetics Protein Kinase Inhibitors - therapeutic use Quinazolines - administration & dosage Quinazolines - adverse effects Quinazolines - pharmacokinetics Quinazolines - therapeutic use Tumor Burden - drug effects Vinblastine - administration & dosage Vinblastine - adverse effects Vinblastine - analogs & derivatives Vinblastine - pharmacokinetics Vinblastine - therapeutic use
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