Squamous Change in Basal-Cell Carcinoma with Drug Resistance

In a 62-year-old woman with advanced basal-cell carcinoma who was treated with vismodegib, a recurrent mass was identified as a squamous-cell carcinoma that shared genetic features with the primary basal-cell tumor. To the Editor: Basal-cell carcinomas are driven by activation of the hedgehog signal...

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Veröffentlicht in:	The New England journal of medicine 2015-09, Vol.373 (11), p.1079-1082
Hauptverfasser:	Ransohoff, Katherine J, Tang, Jean Y, Sarin, Kavita Y
Format:	Artikel
Sprache:	eng
Schlagworte:	Anilides - pharmacology Anilides - therapeutic use Basal cell carcinoma Carcinoma, Basal Cell - genetics Carcinoma, Basal Cell - pathology Carcinoma, Squamous Cell - pathology DNA, Neoplasm - analysis Drug resistance Drug Resistance, Neoplasm Exome Female Health risk assessment Humans Lymphatic Metastasis Metastasis Middle Aged Mutation Pyridines - pharmacology Pyridines - therapeutic use Sequence Analysis, DNA Skin cancer Skin Neoplasms - genetics Skin Neoplasms - pathology
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