The Pore-Forming [alpha]-Toxin from Clostridium septicum Activates the MAPK Pathway in a Ras-c-Raf-Dependent and Independent Manner

Clostridium septicum is the causative agent of atraumatic gas gangrene, with α-toxin, an extracellular pore-forming toxin, essential for disease. How C. septicum modulates the host's innate immune response is poorly defined, although α-toxin-intoxicated muscle cells undergo cellular oncosis, ch...

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Veröffentlicht in:	Toxins 2015-02, Vol.7 (2), p.516
Hauptverfasser:	Chakravorty, Anjana, Awad, Milena M, Cheung, Jackie K, Hiscox, Thomas J, Lyras, Dena, Rood, Julian I
Format:	Artikel
Sprache:	eng
Schlagworte:	Immune response Toxins
Online-Zugang:	Volltext
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