The Phosphoinositide‐Gated Lysosomal Ca2+ Channel, TRPML1, Is Required for Phagosome Maturation

TRPML1 is a lysosomal Ca2+ channel gated by phosphatidylinositol‐3,5‐bisphosphate, a signaling lipid that controls late endosome and lysosome function. Here, we show that TRPML1 is necessary to trigger fusion of lysosomes docked to phagosomes, for efficient killing of phagocytosed bacteria and the r...

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Veröffentlicht in:	Traffic (Copenhagen, Denmark) Denmark), 2015-09, Vol.16 (9), p.1010-1026
Hauptverfasser:	Dayam, Roya M., Saric, Amra, Shilliday, Ryan E., Botelho, Roberto J.
Format:	Artikel
Sprache:	eng
Schlagworte:	calcium lysosomes macrophages organelles phagocytosis phagosome maturation phosphoinositides
Online-Zugang:	Volltext
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