Visualization of the spatial distribution of Pt^sup +^ ions in cisplatin-treated glioblastoma cells by time-of-flight secondary ion mass spectrometry

Human glioblastoma cells (line U87MG) treated by cisplatin were studied using time-of-flight secondary ion mass spectrometry (TOF-SIMS). A spatial distribution of Pt^sup +^ and Na^sup +^ ions and lipids in a cell was determined. The concentration of Pt^sup +^ ions inside the cell nuclei was shown to...

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Veröffentlicht in:	Biochemistry (Moscow). Supplement series A, Membrane and cell biology Membrane and cell biology, 2015-07, Vol.9 (3), p.202
Hauptverfasser:	Gulin, A A, Pavlyukov, M S, Gularyan, S K, Nadtochenko, V A
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Sprache:	eng
Schlagworte:	Cancer Chemotherapy Ions Lipids Mass spectrometry Membranes
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creator	Gulin, A A Pavlyukov, M S Gularyan, S K Nadtochenko, V A
description	Human glioblastoma cells (line U87MG) treated by cisplatin were studied using time-of-flight secondary ion mass spectrometry (TOF-SIMS). A spatial distribution of Pt^sup +^ and Na^sup +^ ions and lipids in a cell was determined. The concentration of Pt^sup +^ ions inside the cell nuclei was shown to be 1.5 times greater than in the cytoplasm. Sphingosine, which is involved in the apoptotic process, was found in cells treated by cisplatin. In control untreated cells, the formation of sphingosine was not detected.
doi_str_mv	10.1134/S1990747815020154
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subjects	Cancer Chemotherapy Ions Lipids Mass spectrometry Membranes
title	Visualization of the spatial distribution of Pt^sup +^ ions in cisplatin-treated glioblastoma cells by time-of-flight secondary ion mass spectrometry
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