Alpha-Synuclein Fibrils Interact with Dopamine Reducing its Cytotoxicity on PC12 Cells

Aggregated alpha-synuclein (α-SYN) is the major component of Lewy bodies and Lewy neurites, two of the pathological hallmarks of Parkinson’s disease (PD). Aggregation of α-SYN leads to toxic species involved in the degeneration of dopaminergic neurons in the midbrain. Different studies suggest a str...

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Veröffentlicht in:	The Protein Journal 2015-08, Vol.34 (4), p.291-303
Hauptverfasser:	Khalife, Masoome, Morshedi, Dina, Aliakbari, Farhang, Tayaranian Marvian, Amir, Mohammad Beigi, Hossein, Azimzadeh Jamalkandi, Sadegh, Pan-Montojo, Francisco
Format:	Artikel
Sprache:	eng
Schlagworte:	Aggregates alpha-Synuclein - chemistry alpha-Synuclein - metabolism alpha-Synuclein - toxicity Animal Anatomy Animals Biochemistry Bioorganic Chemistry Cardiac glycosides Cardiotonic agents Cell Survival - drug effects Cellular biology Chemistry Chemistry and Materials Science Cytotoxicity Dopamine - chemistry Dopamine - metabolism Dopamine - toxicity Ethylenediaminetetraacetic acid Histology Humans Microscopy Morphology Organic Chemistry Parkinson's disease PC12 Cells Phenols Protein Aggregates Proteins Rats Reactive Oxygen Species - metabolism Recombinant Proteins - chemistry Recombinant Proteins - metabolism Recombinant Proteins - toxicity
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