Clinical markers implying the need for treatment in women with gestational diabetes mellitus
To assess the association of the point-of-care hemoglobin A1c (POC A1C), fasting blood glucose (FBG), and BMI with fetal macrosomia and the need for medication in women with gestational diabetes (GDM). POC A1C, FBG, and BMI values at GDM diagnosis and fetal weight at delivery were obtained for women...
Gespeichert in:
| Veröffentlicht in: | Endocrine practice 2012-01, Vol.18 (1), p.62-65 |
|---|---|
| Hauptverfasser: | , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 65 |
|---|---|
| container_issue | 1 |
| container_start_page | 62 |
| container_title | Endocrine practice |
| container_volume | 18 |
| creator | Clayton, Jr, Warren Agarwal, Neena Wang, Li Jagasia, Shubhada |
| description | To assess the association of the point-of-care hemoglobin A1c (POC A1C), fasting blood glucose (FBG), and BMI with fetal macrosomia and the need for medication in women with gestational diabetes (GDM).
POC A1C, FBG, and BMI values at GDM diagnosis and fetal weight at delivery were obtained for women identified from a prospective patient registry. These outcomes were compared between women who did not require medication for GDM and women who did require medication.
Mean values of POC A1C, FBG, and BMI in 67 patients who required medication were higher than those in 71 patients who did not require medication (POC A1C: 5.72 ± 0.45% vs 5.35 ± 0.46% [P |
| doi_str_mv | 10.4158/EP11143.OR |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_journals_1700651761</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>3766331011</sourcerecordid><originalsourceid>FETCH-LOGICAL-c314t-21c9f421d10ca78cefaad8d1456fa67f68f6e555af1b8b2eab2631a069a2cc7c3</originalsourceid><addsrcrecordid>eNo9kEtLAzEUhYMotlY3_gAJuBOm5iaTTGYppT6gUCkKLoQhk0na1HnUJKX03zvS6uqexcfHuQehayDjFLi8n74CQMrG88UJGkLO0oSmhJ32mTOSyBw-BugihDUhlOQgz9GAguSC53KIPie1a51WNW6U_zI-YNds6r1rlziuDG6NqbDtPI7eqNiYNmLX4l3XJ7xzcYWXJkQVXdf2hsqp0kQTcGPq2sVtuERnVtXBXB3vCL0_Tt8mz8ls_vQyeZglmkEaEwo6tymFCohWmdTGKlXJClIurBKZFdIKwzlXFkpZUqNKKhgoInJFtc40G6Hbg3fju-9t36hYd1vfVwoFZIQIDpmAnro7UNp3IXhji413_df7AkjxO2RxHLKYL3r45qjclo2p_tG_5dgPWWVvbg</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1700651761</pqid></control><display><type>article</type><title>Clinical markers implying the need for treatment in women with gestational diabetes mellitus</title><source>MEDLINE</source><source>Alma/SFX Local Collection</source><creator>Clayton, Jr, Warren ; Agarwal, Neena ; Wang, Li ; Jagasia, Shubhada</creator><creatorcontrib>Clayton, Jr, Warren ; Agarwal, Neena ; Wang, Li ; Jagasia, Shubhada</creatorcontrib><description>To assess the association of the point-of-care hemoglobin A1c (POC A1C), fasting blood glucose (FBG), and BMI with fetal macrosomia and the need for medication in women with gestational diabetes (GDM).
POC A1C, FBG, and BMI values at GDM diagnosis and fetal weight at delivery were obtained for women identified from a prospective patient registry. These outcomes were compared between women who did not require medication for GDM and women who did require medication.
Mean values of POC A1C, FBG, and BMI in 67 patients who required medication were higher than those in 71 patients who did not require medication (POC A1C: 5.72 ± 0.45% vs 5.35 ± 0.46% [P<.001]; FBG: 97.4 ± 12.3 mg/dL vs 86.4 ± 9.5 mg/dL [P<.001]; BMI: 35.4 ± 6.4 kg/m2 vs 30.4 ± 6.2 kg/m(2) [P<.001]). There was a modest correlation between POC A1C and FBG (Spearman rho 0.4, P<.001) and between POC A1C and BMI (Spearman rho 0.366, P<.001). Maternal POC A1C was not correlated with fetal weight at delivery (Spearman rho -0.010, P = .915).
Higher POC A1C, FBG, and BMI values were associated with the need for medication in women with GDM. The use of clinical markers to assess glycemic control sooner in pregnancy may lead to the earlier identification of women at risk for GDM and earlier intervention to decrease the risk for complications.</description><identifier>ISSN: 1530-891X</identifier><identifier>EISSN: 1934-2403</identifier><identifier>DOI: 10.4158/EP11143.OR</identifier><identifier>PMID: 21856598</identifier><language>eng</language><publisher>United States: Elsevier Limited</publisher><subject>Adult ; Biomarkers ; Blood Glucose - analysis ; Body Mass Index ; Diabetes, Gestational - diagnosis ; Diabetes, Gestational - drug therapy ; Female ; Fetal Macrosomia - complications ; Fetal Weight - physiology ; Glycated Hemoglobin A - analysis ; Humans ; Hypoglycemic Agents - therapeutic use ; Insulin - therapeutic use ; Point-of-Care Systems ; Pregnancy ; Registries</subject><ispartof>Endocrine practice, 2012-01, Vol.18 (1), p.62-65</ispartof><rights>Copyright Allen Press Publishing Services Jan/Feb 2012</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c314t-21c9f421d10ca78cefaad8d1456fa67f68f6e555af1b8b2eab2631a069a2cc7c3</citedby><cites>FETCH-LOGICAL-c314t-21c9f421d10ca78cefaad8d1456fa67f68f6e555af1b8b2eab2631a069a2cc7c3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,27901,27902</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/21856598$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Clayton, Jr, Warren</creatorcontrib><creatorcontrib>Agarwal, Neena</creatorcontrib><creatorcontrib>Wang, Li</creatorcontrib><creatorcontrib>Jagasia, Shubhada</creatorcontrib><title>Clinical markers implying the need for treatment in women with gestational diabetes mellitus</title><title>Endocrine practice</title><addtitle>Endocr Pract</addtitle><description>To assess the association of the point-of-care hemoglobin A1c (POC A1C), fasting blood glucose (FBG), and BMI with fetal macrosomia and the need for medication in women with gestational diabetes (GDM).
POC A1C, FBG, and BMI values at GDM diagnosis and fetal weight at delivery were obtained for women identified from a prospective patient registry. These outcomes were compared between women who did not require medication for GDM and women who did require medication.
Mean values of POC A1C, FBG, and BMI in 67 patients who required medication were higher than those in 71 patients who did not require medication (POC A1C: 5.72 ± 0.45% vs 5.35 ± 0.46% [P<.001]; FBG: 97.4 ± 12.3 mg/dL vs 86.4 ± 9.5 mg/dL [P<.001]; BMI: 35.4 ± 6.4 kg/m2 vs 30.4 ± 6.2 kg/m(2) [P<.001]). There was a modest correlation between POC A1C and FBG (Spearman rho 0.4, P<.001) and between POC A1C and BMI (Spearman rho 0.366, P<.001). Maternal POC A1C was not correlated with fetal weight at delivery (Spearman rho -0.010, P = .915).
Higher POC A1C, FBG, and BMI values were associated with the need for medication in women with GDM. The use of clinical markers to assess glycemic control sooner in pregnancy may lead to the earlier identification of women at risk for GDM and earlier intervention to decrease the risk for complications.</description><subject>Adult</subject><subject>Biomarkers</subject><subject>Blood Glucose - analysis</subject><subject>Body Mass Index</subject><subject>Diabetes, Gestational - diagnosis</subject><subject>Diabetes, Gestational - drug therapy</subject><subject>Female</subject><subject>Fetal Macrosomia - complications</subject><subject>Fetal Weight - physiology</subject><subject>Glycated Hemoglobin A - analysis</subject><subject>Humans</subject><subject>Hypoglycemic Agents - therapeutic use</subject><subject>Insulin - therapeutic use</subject><subject>Point-of-Care Systems</subject><subject>Pregnancy</subject><subject>Registries</subject><issn>1530-891X</issn><issn>1934-2403</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2012</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>BENPR</sourceid><recordid>eNo9kEtLAzEUhYMotlY3_gAJuBOm5iaTTGYppT6gUCkKLoQhk0na1HnUJKX03zvS6uqexcfHuQehayDjFLi8n74CQMrG88UJGkLO0oSmhJ32mTOSyBw-BugihDUhlOQgz9GAguSC53KIPie1a51WNW6U_zI-YNds6r1rlziuDG6NqbDtPI7eqNiYNmLX4l3XJ7xzcYWXJkQVXdf2hsqp0kQTcGPq2sVtuERnVtXBXB3vCL0_Tt8mz8ls_vQyeZglmkEaEwo6tymFCohWmdTGKlXJClIurBKZFdIKwzlXFkpZUqNKKhgoInJFtc40G6Hbg3fju-9t36hYd1vfVwoFZIQIDpmAnro7UNp3IXhji413_df7AkjxO2RxHLKYL3r45qjclo2p_tG_5dgPWWVvbg</recordid><startdate>201201</startdate><enddate>201201</enddate><creator>Clayton, Jr, Warren</creator><creator>Agarwal, Neena</creator><creator>Wang, Li</creator><creator>Jagasia, Shubhada</creator><general>Elsevier Limited</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7RV</scope><scope>7X7</scope><scope>7XB</scope><scope>88C</scope><scope>88E</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>K9-</scope><scope>K9.</scope><scope>KB0</scope><scope>M0R</scope><scope>M0S</scope><scope>M0T</scope><scope>M1P</scope><scope>NAPCQ</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope></search><sort><creationdate>201201</creationdate><title>Clinical markers implying the need for treatment in women with gestational diabetes mellitus</title><author>Clayton, Jr, Warren ; Agarwal, Neena ; Wang, Li ; Jagasia, Shubhada</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c314t-21c9f421d10ca78cefaad8d1456fa67f68f6e555af1b8b2eab2631a069a2cc7c3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2012</creationdate><topic>Adult</topic><topic>Biomarkers</topic><topic>Blood Glucose - analysis</topic><topic>Body Mass Index</topic><topic>Diabetes, Gestational - diagnosis</topic><topic>Diabetes, Gestational - drug therapy</topic><topic>Female</topic><topic>Fetal Macrosomia - complications</topic><topic>Fetal Weight - physiology</topic><topic>Glycated Hemoglobin A - analysis</topic><topic>Humans</topic><topic>Hypoglycemic Agents - therapeutic use</topic><topic>Insulin - therapeutic use</topic><topic>Point-of-Care Systems</topic><topic>Pregnancy</topic><topic>Registries</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Clayton, Jr, Warren</creatorcontrib><creatorcontrib>Agarwal, Neena</creatorcontrib><creatorcontrib>Wang, Li</creatorcontrib><creatorcontrib>Jagasia, Shubhada</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Nursing & Allied Health Database</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Healthcare Administration Database (Alumni)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>Consumer Health Database (Alumni Edition)</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Database (Alumni Edition)</collection><collection>Consumer Health Database</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Healthcare Administration Database</collection><collection>Medical Database</collection><collection>Nursing & Allied Health Premium</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><jtitle>Endocrine practice</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Clayton, Jr, Warren</au><au>Agarwal, Neena</au><au>Wang, Li</au><au>Jagasia, Shubhada</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Clinical markers implying the need for treatment in women with gestational diabetes mellitus</atitle><jtitle>Endocrine practice</jtitle><addtitle>Endocr Pract</addtitle><date>2012-01</date><risdate>2012</risdate><volume>18</volume><issue>1</issue><spage>62</spage><epage>65</epage><pages>62-65</pages><issn>1530-891X</issn><eissn>1934-2403</eissn><abstract>To assess the association of the point-of-care hemoglobin A1c (POC A1C), fasting blood glucose (FBG), and BMI with fetal macrosomia and the need for medication in women with gestational diabetes (GDM).
POC A1C, FBG, and BMI values at GDM diagnosis and fetal weight at delivery were obtained for women identified from a prospective patient registry. These outcomes were compared between women who did not require medication for GDM and women who did require medication.
Mean values of POC A1C, FBG, and BMI in 67 patients who required medication were higher than those in 71 patients who did not require medication (POC A1C: 5.72 ± 0.45% vs 5.35 ± 0.46% [P<.001]; FBG: 97.4 ± 12.3 mg/dL vs 86.4 ± 9.5 mg/dL [P<.001]; BMI: 35.4 ± 6.4 kg/m2 vs 30.4 ± 6.2 kg/m(2) [P<.001]). There was a modest correlation between POC A1C and FBG (Spearman rho 0.4, P<.001) and between POC A1C and BMI (Spearman rho 0.366, P<.001). Maternal POC A1C was not correlated with fetal weight at delivery (Spearman rho -0.010, P = .915).
Higher POC A1C, FBG, and BMI values were associated with the need for medication in women with GDM. The use of clinical markers to assess glycemic control sooner in pregnancy may lead to the earlier identification of women at risk for GDM and earlier intervention to decrease the risk for complications.</abstract><cop>United States</cop><pub>Elsevier Limited</pub><pmid>21856598</pmid><doi>10.4158/EP11143.OR</doi><tpages>4</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 1530-891X |
| ispartof | Endocrine practice, 2012-01, Vol.18 (1), p.62-65 |
| issn | 1530-891X 1934-2403 |
| language | eng |
| recordid | cdi_proquest_journals_1700651761 |
| source | MEDLINE; Alma/SFX Local Collection |
| subjects | Adult Biomarkers Blood Glucose - analysis Body Mass Index Diabetes, Gestational - diagnosis Diabetes, Gestational - drug therapy Female Fetal Macrosomia - complications Fetal Weight - physiology Glycated Hemoglobin A - analysis Humans Hypoglycemic Agents - therapeutic use Insulin - therapeutic use Point-of-Care Systems Pregnancy Registries |
| title | Clinical markers implying the need for treatment in women with gestational diabetes mellitus |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-02-05T10%3A53%3A51IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Clinical%20markers%20implying%20the%20need%20for%20treatment%20in%20women%20with%20gestational%20diabetes%20mellitus&rft.jtitle=Endocrine%20practice&rft.au=Clayton,%20Jr,%20Warren&rft.date=2012-01&rft.volume=18&rft.issue=1&rft.spage=62&rft.epage=65&rft.pages=62-65&rft.issn=1530-891X&rft.eissn=1934-2403&rft_id=info:doi/10.4158/EP11143.OR&rft_dat=%3Cproquest_cross%3E3766331011%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=1700651761&rft_id=info:pmid/21856598&rfr_iscdi=true |