Synthesis and antimicrobial properties of camphorsulfonic acid derived imidazolium salts
A group of homochiral imidazolium salts bearing hydrophobic camphor derived moiety and ester or amide functional group were synthesized and characterized. The novel imidazolium bromides were tested as antimicrobial and antifungal agents and their minimal inhibitory concentration (MIC) was evaluated...
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| Veröffentlicht in: | Acta Facultatis Pharmaceuticae Universitatis Comenianae 2014-12, Vol.61 (2), p.42-48 |
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| container_title | Acta Facultatis Pharmaceuticae Universitatis Comenianae |
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| creator | Miklas, R Miklasova, N Bukovsky, M Devinsky, F |
| description | A group of homochiral imidazolium salts bearing hydrophobic camphor derived moiety and ester or amide functional group were synthesized and characterized. The novel imidazolium bromides were tested as antimicrobial and antifungal agents and their minimal inhibitory concentration (MIC) was evaluated and compared to clinically used benzalkonium bromide (BAB) and carbethopendecinium bromide. The MIC values of amide derivatives 2a and 2b were slightly smaller than those for BAB, indicating their good activity. None of the prepared salts was more effective than carbethopendecinium bromide. The biocidal efficacy of amide derivatives was much higher compared to the ester analogues. |
| doi_str_mv | 10.2478/afpuc-2014-0007 |
| format | Article |
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The novel imidazolium bromides were tested as antimicrobial and antifungal agents and their minimal inhibitory concentration (MIC) was evaluated and compared to clinically used benzalkonium bromide (BAB) and carbethopendecinium bromide. The MIC values of amide derivatives 2a and 2b were slightly smaller than those for BAB, indicating their good activity. None of the prepared salts was more effective than carbethopendecinium bromide. The biocidal efficacy of amide derivatives was much higher compared to the ester analogues.</description><identifier>ISSN: 1338-6786</identifier><identifier>ISSN: 0301-2298</identifier><identifier>EISSN: 1338-6786</identifier><identifier>EISSN: 2453-6725</identifier><identifier>DOI: 10.2478/afpuc-2014-0007</identifier><language>eng</language><publisher>Bratislava: De Gruyter Open</publisher><subject>antimicrobial activity ; camphorsulfonic acid ; Chemical synthesis ; imidazolium salts ; Salt ; Sulfuric acid</subject><ispartof>Acta Facultatis Pharmaceuticae Universitatis Comenianae, 2014-12, Vol.61 (2), p.42-48</ispartof><rights>Copyright De Gruyter Open Sp. z o.o. 2014</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c3112-1db06f7bf27c5f34706984be717469afac65eb58be6565fc8cc7ec5f7482f9493</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.proquest.com/docview/1698160426?pq-origsite=primo$$EHTML$$P50$$Gproquest$$Hfree_for_read</linktohtml><link.rule.ids>314,780,784,864,21388,21389,27924,27925,33530,33744,43659,43805,64385,64389,72469</link.rule.ids></links><search><creatorcontrib>Miklas, R</creatorcontrib><creatorcontrib>Miklasova, N</creatorcontrib><creatorcontrib>Bukovsky, M</creatorcontrib><creatorcontrib>Devinsky, F</creatorcontrib><title>Synthesis and antimicrobial properties of camphorsulfonic acid derived imidazolium salts</title><title>Acta Facultatis Pharmaceuticae Universitatis Comenianae</title><description>A group of homochiral imidazolium salts bearing hydrophobic camphor derived moiety and ester or amide functional group were synthesized and characterized. 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The biocidal efficacy of amide derivatives was much higher compared to the ester analogues.</description><subject>antimicrobial activity</subject><subject>camphorsulfonic acid</subject><subject>Chemical synthesis</subject><subject>imidazolium salts</subject><subject>Salt</subject><subject>Sulfuric acid</subject><issn>1338-6786</issn><issn>0301-2298</issn><issn>1338-6786</issn><issn>2453-6725</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2014</creationdate><recordtype>article</recordtype><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><recordid>eNptkE1LxDAQhosoKLpnrwEvXuomaZqk4EUWv2DBgwreQppO3Ejb1KRV1l9v1vWwiIchc3jemcmTZacEX1Am5FzbYTI5xYTlGGOxlx2RopA5F5Lv7_SH2SzGt0RgTnnJ-FH28rjuxxVEF5Hum1Sj65wJvna6RUPwA4TRQUTeIqO7YeVDnFrre2eQNq5BDQT3AQ1KqUZ_-dZNHYq6HeNJdmB1G2H2-x5nzzfXT4u7fPlwe7-4WuamIITmpKkxt6K2VJjSFkxgXklWgyCC8UpbbXgJdSlr4CUvrZHGCEikYJLailXFcXa-nZuOfZ8gjqpz0UDb6h78FBWRVMiqEgwn9OwP-uan0KfrFElbCceM8kTNt1SyEGMAq4bgOh3WimC1ka1-ZKuNbLWRnRKX28Rn-jiEBl7DtE7Nzvj_k5xQRotvYneIBg</recordid><startdate>20141230</startdate><enddate>20141230</enddate><creator>Miklas, R</creator><creator>Miklasova, N</creator><creator>Bukovsky, M</creator><creator>Devinsky, F</creator><general>De Gruyter Open</general><general>De Gruyter Poland</general><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7X7</scope><scope>7XB</scope><scope>8AO</scope><scope>8C1</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>BYOGL</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>K9.</scope><scope>M0S</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>7T7</scope><scope>8FD</scope><scope>C1K</scope><scope>FR3</scope><scope>P64</scope></search><sort><creationdate>20141230</creationdate><title>Synthesis and antimicrobial properties of camphorsulfonic acid derived imidazolium salts</title><author>Miklas, R ; 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| identifier | ISSN: 1338-6786 |
| ispartof | Acta Facultatis Pharmaceuticae Universitatis Comenianae, 2014-12, Vol.61 (2), p.42-48 |
| issn | 1338-6786 0301-2298 1338-6786 2453-6725 |
| language | eng |
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| source | ProQuest Central (Alumni Edition); DOAJ Directory of Open Access Journals; Walter De Gruyter: Open Access Journals; ProQuest Central UK/Ireland; ProQuest Central |
| subjects | antimicrobial activity camphorsulfonic acid Chemical synthesis imidazolium salts Salt Sulfuric acid |
| title | Synthesis and antimicrobial properties of camphorsulfonic acid derived imidazolium salts |
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