Neutrons in studies of phospholipid bilayers and bilayer–drug interaction. II. Small-angle scattering

In this paper, we demonstrate several possibilities of using neutron scattering in pharmaceutical research based on examples of scientific results achieved at our University. In this second part, elementary principles of small-angle neutron scattering and simple methods of scattering data evaluation...

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Veröffentlicht in:Acta Facultatis Pharmaceuticae Universitatis Comenianae 2014-12, Vol.61 (2), p.12-20
Hauptverfasser: Belička, M., Devínsky, F., Balgavý, P.
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creator Belička, M.
Devínsky, F.
Balgavý, P.
description In this paper, we demonstrate several possibilities of using neutron scattering in pharmaceutical research based on examples of scientific results achieved at our University. In this second part, elementary principles of small-angle neutron scattering and simple methods of scattering data evaluation are described. Results of scattering on bilayers in unilamellar liposomes with intercalated general anaesthetics, antimicrobials or cholesterol demonstrate the potential of this method at determination of structural properties of bilayers.
doi_str_mv 10.2478/afpuc-2014-0011
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subjects alkan-1-ol
alkanes
cholesterol
Drug therapy
lipid bilayer
Lipids
neutron scattering
Neutrons
phospholipid liposomes
Phosphorus content
Scattering
title Neutrons in studies of phospholipid bilayers and bilayer–drug interaction. II. Small-angle scattering
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