Unusual clinical course of Graves' thyrotoxicosis and concomitant sarcoidosis: case report and review of literature
To report a case of Graves' disease with concomitant sarcoidosis involving the thyroid gland. We present the clinical, laboratory, imaging, and pathologic findings and describe the clinical course of a patient with Graves' disease and sarcoidosis, who was unresponsive to propylthiouracil a...
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| Veröffentlicht in: | Endocrine practice 2007-03, Vol.13 (2), p.159-163 |
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| creator | Rodriguez, Monica C Rani, Dolly Faas, Fred H |
| description | To report a case of Graves' disease with concomitant sarcoidosis involving the thyroid gland.
We present the clinical, laboratory, imaging, and pathologic findings and describe the clinical course of a patient with Graves' disease and sarcoidosis, who was unresponsive to propylthiouracil and radioiodine treatment.
A 23-year-old woman presented with thyrotoxicosis and a large goiter. Laboratory studies and findings on thyroid uptake and scan were consistent with Graves' disease. She was also found to have hilar lymphadenopathy and hepatosplenomegaly. Despite treatment with antithyroid drugs and radioiodine therapy, her hyperthyroidism persisted. Surgical resection of the thyroid gland and 2 lymph nodes disclosed noncaseating granulomas, consistent with sarcoid.
Autoimmune endocrinopathies and, less commonly, thyroid autoimmune disease have been reported in patients with sarcoidosis. Similarities exist in the pathogenesis of these two conditions. Concomitant sarcoidosis in the thyroid gland in patients with Graves' disease may contribute to the resistance to antithyroid drugs and radioiodine therapy. |
| doi_str_mv | 10.4158/EP.13.2.159 |
| format | Article |
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We present the clinical, laboratory, imaging, and pathologic findings and describe the clinical course of a patient with Graves' disease and sarcoidosis, who was unresponsive to propylthiouracil and radioiodine treatment.
A 23-year-old woman presented with thyrotoxicosis and a large goiter. Laboratory studies and findings on thyroid uptake and scan were consistent with Graves' disease. She was also found to have hilar lymphadenopathy and hepatosplenomegaly. Despite treatment with antithyroid drugs and radioiodine therapy, her hyperthyroidism persisted. Surgical resection of the thyroid gland and 2 lymph nodes disclosed noncaseating granulomas, consistent with sarcoid.
Autoimmune endocrinopathies and, less commonly, thyroid autoimmune disease have been reported in patients with sarcoidosis. Similarities exist in the pathogenesis of these two conditions. Concomitant sarcoidosis in the thyroid gland in patients with Graves' disease may contribute to the resistance to antithyroid drugs and radioiodine therapy.</description><identifier>ISSN: 1530-891X</identifier><identifier>EISSN: 1934-2403</identifier><identifier>DOI: 10.4158/EP.13.2.159</identifier><identifier>PMID: 17490930</identifier><language>eng</language><publisher>United States: Elsevier Limited</publisher><subject>Adult ; Antithyroid Agents - therapeutic use ; Drug Resistance ; Female ; Goiter - pathology ; Graves Disease - diagnosis ; Graves Disease - drug therapy ; Graves Disease - pathology ; Humans ; Iodine Radioisotopes - therapeutic use ; Lymphatic Diseases - pathology ; Propylthiouracil - therapeutic use ; Sarcoidosis - diagnosis ; Sarcoidosis - drug therapy ; Sarcoidosis - pathology ; Thyroid Gland - drug effects ; Thyroid Gland - pathology ; Thyroid Gland - surgery ; Thyrotoxicosis - diagnosis ; Thyrotoxicosis - drug therapy ; Thyrotoxicosis - pathology</subject><ispartof>Endocrine practice, 2007-03, Vol.13 (2), p.159-163</ispartof><rights>Copyright Allen Press Publishing Services Mar/Apr 2007</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c230t-36e28e089b809f1d3e787ad43e97102d057cc2d9b1253b2350ce8810b5f4d6b83</citedby><cites>FETCH-LOGICAL-c230t-36e28e089b809f1d3e787ad43e97102d057cc2d9b1253b2350ce8810b5f4d6b83</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.proquest.com/docview/1697189426?pq-origsite=primo$$EHTML$$P50$$Gproquest$$H</linktohtml><link.rule.ids>314,780,784,27923,27924,64384,64388,72240</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/17490930$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Rodriguez, Monica C</creatorcontrib><creatorcontrib>Rani, Dolly</creatorcontrib><creatorcontrib>Faas, Fred H</creatorcontrib><title>Unusual clinical course of Graves' thyrotoxicosis and concomitant sarcoidosis: case report and review of literature</title><title>Endocrine practice</title><addtitle>Endocr Pract</addtitle><description>To report a case of Graves' disease with concomitant sarcoidosis involving the thyroid gland.
We present the clinical, laboratory, imaging, and pathologic findings and describe the clinical course of a patient with Graves' disease and sarcoidosis, who was unresponsive to propylthiouracil and radioiodine treatment.
A 23-year-old woman presented with thyrotoxicosis and a large goiter. Laboratory studies and findings on thyroid uptake and scan were consistent with Graves' disease. She was also found to have hilar lymphadenopathy and hepatosplenomegaly. Despite treatment with antithyroid drugs and radioiodine therapy, her hyperthyroidism persisted. Surgical resection of the thyroid gland and 2 lymph nodes disclosed noncaseating granulomas, consistent with sarcoid.
Autoimmune endocrinopathies and, less commonly, thyroid autoimmune disease have been reported in patients with sarcoidosis. Similarities exist in the pathogenesis of these two conditions. Concomitant sarcoidosis in the thyroid gland in patients with Graves' disease may contribute to the resistance to antithyroid drugs and radioiodine therapy.</description><subject>Adult</subject><subject>Antithyroid Agents - therapeutic use</subject><subject>Drug Resistance</subject><subject>Female</subject><subject>Goiter - pathology</subject><subject>Graves Disease - diagnosis</subject><subject>Graves Disease - drug therapy</subject><subject>Graves Disease - pathology</subject><subject>Humans</subject><subject>Iodine Radioisotopes - therapeutic use</subject><subject>Lymphatic Diseases - pathology</subject><subject>Propylthiouracil - therapeutic use</subject><subject>Sarcoidosis - diagnosis</subject><subject>Sarcoidosis - drug therapy</subject><subject>Sarcoidosis - pathology</subject><subject>Thyroid Gland - drug effects</subject><subject>Thyroid Gland - pathology</subject><subject>Thyroid Gland - surgery</subject><subject>Thyrotoxicosis - diagnosis</subject><subject>Thyrotoxicosis - drug therapy</subject><subject>Thyrotoxicosis - pathology</subject><issn>1530-891X</issn><issn>1934-2403</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2007</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><recordid>eNpFkE1LAzEQhoMotlZP3mXBgwfZNR_7kXiTUqtQsAcL3kI2yWLKdlOTbLX_3qwteJqBeeYZ5gXgGsEsRwV9mC0zRDKcoYKdgDFiJE9xDslp7AsCU8rQxwhceL-GEEOG6DkYoSpnkBE4Bn7V9b4XbSJb0xk5NLZ3Xie2SeZO7LS_S8Ln3tlgf4y03vhEdCpCnbQbE0QXEi-ctEYNs8dEirjr9Na68Ac6vTP6e7C1JmgnQu_0JThrROv11bFOwOp59j59SRdv89fp0yKVmMCQklJjqiFlNYWsQYroilZC5USzCkGsYFFJiRWrES5IjUkBpaYUwbpoclXWlEzA7cG7dfar1z7wdfytiyc5KqODshyXkbo_UNJZ751u-NaZjXB7jiAfAuazJUeEYx4DjvTN0dnXG63-2WOi5BdQCHcl</recordid><startdate>200703</startdate><enddate>200703</enddate><creator>Rodriguez, Monica C</creator><creator>Rani, Dolly</creator><creator>Faas, Fred H</creator><general>Elsevier Limited</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7RV</scope><scope>7X7</scope><scope>7XB</scope><scope>88C</scope><scope>88E</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>K9-</scope><scope>K9.</scope><scope>KB0</scope><scope>M0R</scope><scope>M0S</scope><scope>M0T</scope><scope>M1P</scope><scope>NAPCQ</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope></search><sort><creationdate>200703</creationdate><title>Unusual clinical course of Graves' thyrotoxicosis and concomitant sarcoidosis: case report and review of literature</title><author>Rodriguez, Monica C ; 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We present the clinical, laboratory, imaging, and pathologic findings and describe the clinical course of a patient with Graves' disease and sarcoidosis, who was unresponsive to propylthiouracil and radioiodine treatment.
A 23-year-old woman presented with thyrotoxicosis and a large goiter. Laboratory studies and findings on thyroid uptake and scan were consistent with Graves' disease. She was also found to have hilar lymphadenopathy and hepatosplenomegaly. Despite treatment with antithyroid drugs and radioiodine therapy, her hyperthyroidism persisted. Surgical resection of the thyroid gland and 2 lymph nodes disclosed noncaseating granulomas, consistent with sarcoid.
Autoimmune endocrinopathies and, less commonly, thyroid autoimmune disease have been reported in patients with sarcoidosis. Similarities exist in the pathogenesis of these two conditions. Concomitant sarcoidosis in the thyroid gland in patients with Graves' disease may contribute to the resistance to antithyroid drugs and radioiodine therapy.</abstract><cop>United States</cop><pub>Elsevier Limited</pub><pmid>17490930</pmid><doi>10.4158/EP.13.2.159</doi><tpages>5</tpages></addata></record> |
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| ispartof | Endocrine practice, 2007-03, Vol.13 (2), p.159-163 |
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| subjects | Adult Antithyroid Agents - therapeutic use Drug Resistance Female Goiter - pathology Graves Disease - diagnosis Graves Disease - drug therapy Graves Disease - pathology Humans Iodine Radioisotopes - therapeutic use Lymphatic Diseases - pathology Propylthiouracil - therapeutic use Sarcoidosis - diagnosis Sarcoidosis - drug therapy Sarcoidosis - pathology Thyroid Gland - drug effects Thyroid Gland - pathology Thyroid Gland - surgery Thyrotoxicosis - diagnosis Thyrotoxicosis - drug therapy Thyrotoxicosis - pathology |
| title | Unusual clinical course of Graves' thyrotoxicosis and concomitant sarcoidosis: case report and review of literature |
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