PDGFR[beta] signalling regulates local inflammation and synergizes with hypercholesterolaemia to promote atherosclerosis

Platelet-derived growth factor (PDGF) is a mitogen and chemoattractant for vascular smooth muscle cells (VSMCs). However, the direct effects of PDGF receptor β (PDGFRβ) activation on VSMCs have not been studied in the context of atherosclerosis. Here we present a new mouse model of atherosclerosis w...

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Veröffentlicht in:	Nature communications 2015-07, Vol.6, p.7770
Hauptverfasser:	He, Chaoyong, Medley, Shayna C, Hu, Taishan, Hinsdale, Myron E, Lupu, Florea, Virmani, Renu, Olson, Lorin E
Format:	Artikel
Sprache:	eng
Schlagworte:	Atherosclerosis Chemokines Coronary vessels Genotype & phenotype Growth factors Health sciences Heart attacks Kinases Leukocytes Ligands Medical research Mutation Smooth muscle
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