Ultrasonographic Assessment of Soft Tissues in Patients With Acromegaly
Objectives: This study aims to investigate ultrasound examination findings of cartilage, tendon and nerve structures in patients with acromegaly and assess whether imaging findings have any association with the clinical and laboratory features of the patients. Patients and methods: The study include...
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| Veröffentlicht in: | Archives of rheumatology 2015-06, Vol.30 (2), p.138-143 |
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| container_title | Archives of rheumatology |
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| creator | Kocak, Mustafa Civan, Nadim Karkucak, Murat Capkin, Erhan Garipoglu, Melek Can, Ipek Karaca, Adem Tasdelen, Mustafa Ayar, Ahmet |
| description | Objectives: This study aims to investigate ultrasound examination findings of cartilage, tendon and nerve structures in patients with acromegaly and assess whether imaging findings have any association with the clinical and laboratory features of the patients. Patients and methods: The study included 38 diagnosed acromegaly patients (18 males, 20 females; mean age 45.6 ± 10.4 years; range 28 to 63 years) and 21 control subjects (8 males, 13 females; mean age; 43.1 [+ or -] 7.4 years; range 29 to 58 years) similar for age, sex and body mass index. Patients' clinical characteristics and laboratory parameters were recorded. The cross sectional area of median nerve, flexor pollicis longus and Achilles tendon, and humeral cartilage thickness were bilaterally assessed by ultrasound. Results: Arthralgia was present in 13 patients (34.9%) and 11 (28.9%) had paresthesia in the hands. Thickness of humeral cartilage and the cross sectional area of median nerve, flexor pollicis longus tendon and Achilles tendon was significantly higher in acromegaly patients compared with controls (p |
| doi_str_mv | 10.5606/ArchRheumatol.2015.5158 |
| format | Article |
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Patients and methods: The study included 38 diagnosed acromegaly patients (18 males, 20 females; mean age 45.6 ± 10.4 years; range 28 to 63 years) and 21 control subjects (8 males, 13 females; mean age; 43.1 [+ or -] 7.4 years; range 29 to 58 years) similar for age, sex and body mass index. Patients' clinical characteristics and laboratory parameters were recorded. The cross sectional area of median nerve, flexor pollicis longus and Achilles tendon, and humeral cartilage thickness were bilaterally assessed by ultrasound. Results: Arthralgia was present in 13 patients (34.9%) and 11 (28.9%) had paresthesia in the hands. Thickness of humeral cartilage and the cross sectional area of median nerve, flexor pollicis longus tendon and Achilles tendon was significantly higher in acromegaly patients compared with controls (p<0.001). While measurements performed with ultrasound were correlated among themselves, no significant correlation was present between ultrasound measurements and growth hormone and insulin-like growth factor-1. When acromegaly patients were analyzed as active (n=22) and inactive (n=16), no significant difference was determined in the parameters with the exception of median nerve measurements. Conclusion: Ultrasound examination revealed significantly different cartilage, tendon and nerve parameters in acromegaly patients compared to the control group. Median nerve cross sectional area was significantly greater in active patients compared to inactive patients. Keywords: Acromegaly; soft tissue structures; ultrasound.</description><identifier>ISSN: 2148-5046</identifier><identifier>ISSN: 1309-0291</identifier><identifier>EISSN: 1309-0283</identifier><identifier>DOI: 10.5606/ArchRheumatol.2015.5158</identifier><language>eng</language><publisher>Istanbul: Turkish League Against Rheumatism</publisher><subject>Acromegaly ; Body mass index ; Care and treatment ; Diagnosis ; Somatotropin</subject><ispartof>Archives of rheumatology, 2015-06, Vol.30 (2), p.138-143</ispartof><rights>COPYRIGHT 2015 Turkish League Against Rheumatism</rights><rights>Copyright Prof Sebnem Ataman, President Turkish League Against Rheumatism 2015</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c502t-7e5e8b9a7857cb7af9120f792b6441a9938984ff1dfbc788a1a9934f0c82aa2b3</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids></links><search><creatorcontrib>Kocak, Mustafa</creatorcontrib><creatorcontrib>Civan, Nadim</creatorcontrib><creatorcontrib>Karkucak, Murat</creatorcontrib><creatorcontrib>Capkin, Erhan</creatorcontrib><creatorcontrib>Garipoglu, Melek</creatorcontrib><creatorcontrib>Can, Ipek</creatorcontrib><creatorcontrib>Karaca, Adem</creatorcontrib><creatorcontrib>Tasdelen, Mustafa</creatorcontrib><creatorcontrib>Ayar, Ahmet</creatorcontrib><title>Ultrasonographic Assessment of Soft Tissues in Patients With Acromegaly</title><title>Archives of rheumatology</title><description>Objectives: This study aims to investigate ultrasound examination findings of cartilage, tendon and nerve structures in patients with acromegaly and assess whether imaging findings have any association with the clinical and laboratory features of the patients. Patients and methods: The study included 38 diagnosed acromegaly patients (18 males, 20 females; mean age 45.6 ± 10.4 years; range 28 to 63 years) and 21 control subjects (8 males, 13 females; mean age; 43.1 [+ or -] 7.4 years; range 29 to 58 years) similar for age, sex and body mass index. Patients' clinical characteristics and laboratory parameters were recorded. The cross sectional area of median nerve, flexor pollicis longus and Achilles tendon, and humeral cartilage thickness were bilaterally assessed by ultrasound. Results: Arthralgia was present in 13 patients (34.9%) and 11 (28.9%) had paresthesia in the hands. Thickness of humeral cartilage and the cross sectional area of median nerve, flexor pollicis longus tendon and Achilles tendon was significantly higher in acromegaly patients compared with controls (p<0.001). While measurements performed with ultrasound were correlated among themselves, no significant correlation was present between ultrasound measurements and growth hormone and insulin-like growth factor-1. When acromegaly patients were analyzed as active (n=22) and inactive (n=16), no significant difference was determined in the parameters with the exception of median nerve measurements. Conclusion: Ultrasound examination revealed significantly different cartilage, tendon and nerve parameters in acromegaly patients compared to the control group. Median nerve cross sectional area was significantly greater in active patients compared to inactive patients. Keywords: Acromegaly; soft tissue structures; ultrasound.</description><subject>Acromegaly</subject><subject>Body mass index</subject><subject>Care and treatment</subject><subject>Diagnosis</subject><subject>Somatotropin</subject><issn>2148-5046</issn><issn>1309-0291</issn><issn>1309-0283</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2015</creationdate><recordtype>article</recordtype><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><recordid>eNptkU1LJDEQhoOs4OD6G2wQ9tZjkk46ybGR3VEQXHYVjyGdSaYj3Z3ZVOYw_96Mijiw1KGg6qnPF6FLgpe8xe11l-zwZ3C7yeQ4LikmfMkJlydoQRqsakxl8w0tKGGy5pi1Z-gC4AVjTJhoW9ws0OppzMlAnOMmme0QbNUBOIDJzbmKvvobfa4eA8DOQRXm6rfJoaSgeg55qDqb4uQ2Ztx_R6fejOAuPvw5evr18_Hmtr5_WN3ddPe15ZjmWjjuZK-MkFzYXhivCMVeKNq3jBGjVCOVZN6Tte-tkNK8xZjHVlJjaN-co6v3vtsU_5Wdsn6JuzSXkZq0igqGebn5kyqrOR1mH8uRdgpgdceIEu1hTKGW_6GKrd0UbJydDyV-VPDjS8HgzJgHiOMuhzjDMSjewfIfgOS83qYwmbTXBOuDcPpIOH0QTh-Ea14B14mNgg</recordid><startdate>20150601</startdate><enddate>20150601</enddate><creator>Kocak, Mustafa</creator><creator>Civan, Nadim</creator><creator>Karkucak, Murat</creator><creator>Capkin, Erhan</creator><creator>Garipoglu, Melek</creator><creator>Can, Ipek</creator><creator>Karaca, Adem</creator><creator>Tasdelen, Mustafa</creator><creator>Ayar, Ahmet</creator><general>Turkish League Against Rheumatism</general><general>Prof Sebnem Ataman, President Turkish League Against Rheumatism</general><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7X7</scope><scope>7XB</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>EDSIH</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>K9.</scope><scope>M0S</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope></search><sort><creationdate>20150601</creationdate><title>Ultrasonographic Assessment of Soft Tissues in Patients With Acromegaly</title><author>Kocak, Mustafa ; Civan, Nadim ; Karkucak, Murat ; Capkin, Erhan ; Garipoglu, Melek ; Can, Ipek ; Karaca, Adem ; Tasdelen, Mustafa ; Ayar, Ahmet</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c502t-7e5e8b9a7857cb7af9120f792b6441a9938984ff1dfbc788a1a9934f0c82aa2b3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2015</creationdate><topic>Acromegaly</topic><topic>Body mass index</topic><topic>Care and treatment</topic><topic>Diagnosis</topic><topic>Somatotropin</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Kocak, Mustafa</creatorcontrib><creatorcontrib>Civan, Nadim</creatorcontrib><creatorcontrib>Karkucak, Murat</creatorcontrib><creatorcontrib>Capkin, Erhan</creatorcontrib><creatorcontrib>Garipoglu, Melek</creatorcontrib><creatorcontrib>Can, Ipek</creatorcontrib><creatorcontrib>Karaca, Adem</creatorcontrib><creatorcontrib>Tasdelen, Mustafa</creatorcontrib><creatorcontrib>Ayar, Ahmet</creatorcontrib><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>Turkey Database</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><jtitle>Archives of rheumatology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Kocak, Mustafa</au><au>Civan, Nadim</au><au>Karkucak, Murat</au><au>Capkin, Erhan</au><au>Garipoglu, Melek</au><au>Can, Ipek</au><au>Karaca, Adem</au><au>Tasdelen, Mustafa</au><au>Ayar, Ahmet</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Ultrasonographic Assessment of Soft Tissues in Patients With Acromegaly</atitle><jtitle>Archives of rheumatology</jtitle><date>2015-06-01</date><risdate>2015</risdate><volume>30</volume><issue>2</issue><spage>138</spage><epage>143</epage><pages>138-143</pages><issn>2148-5046</issn><issn>1309-0291</issn><eissn>1309-0283</eissn><abstract>Objectives: This study aims to investigate ultrasound examination findings of cartilage, tendon and nerve structures in patients with acromegaly and assess whether imaging findings have any association with the clinical and laboratory features of the patients. Patients and methods: The study included 38 diagnosed acromegaly patients (18 males, 20 females; mean age 45.6 ± 10.4 years; range 28 to 63 years) and 21 control subjects (8 males, 13 females; mean age; 43.1 [+ or -] 7.4 years; range 29 to 58 years) similar for age, sex and body mass index. Patients' clinical characteristics and laboratory parameters were recorded. The cross sectional area of median nerve, flexor pollicis longus and Achilles tendon, and humeral cartilage thickness were bilaterally assessed by ultrasound. Results: Arthralgia was present in 13 patients (34.9%) and 11 (28.9%) had paresthesia in the hands. Thickness of humeral cartilage and the cross sectional area of median nerve, flexor pollicis longus tendon and Achilles tendon was significantly higher in acromegaly patients compared with controls (p<0.001). While measurements performed with ultrasound were correlated among themselves, no significant correlation was present between ultrasound measurements and growth hormone and insulin-like growth factor-1. When acromegaly patients were analyzed as active (n=22) and inactive (n=16), no significant difference was determined in the parameters with the exception of median nerve measurements. Conclusion: Ultrasound examination revealed significantly different cartilage, tendon and nerve parameters in acromegaly patients compared to the control group. Median nerve cross sectional area was significantly greater in active patients compared to inactive patients. Keywords: Acromegaly; soft tissue structures; ultrasound.</abstract><cop>Istanbul</cop><pub>Turkish League Against Rheumatism</pub><doi>10.5606/ArchRheumatol.2015.5158</doi><tpages>6</tpages><oa>free_for_read</oa></addata></record> |
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| source | Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; Alma/SFX Local Collection |
| subjects | Acromegaly Body mass index Care and treatment Diagnosis Somatotropin |
| title | Ultrasonographic Assessment of Soft Tissues in Patients With Acromegaly |
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