Preparation of pH-sensitive nanoparticles of poly (methacrylic acid) (PMAA)/poly (vinyl pyrrolidone) (PVP) by ATRP-template miniemulsion polymerization in the aqueous solution
Employing polymethacrylic acid (PMAA) as the template and N -vinyl pyrrolidone (N-VP) as monomer, the ATRP-template miniemulsion polymerization was carried out in the aqueous medium by using MBP/CuBr/bpy as initiator. The results were characterized by dynamic light scattering (DLS), transmission ele...
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| Veröffentlicht in: | Colloid and polymer science 2015-07, Vol.293 (7), p.2035-2044 |
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| container_title | Colloid and polymer science |
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| creator | Chen, Guoxia Liu, Junxiu Yang, Yadong Zhang, Lijuan Wu, Min Ni, Henmei |
| description | Employing polymethacrylic acid (PMAA) as the template and
N
-vinyl pyrrolidone (N-VP) as monomer, the ATRP-template miniemulsion polymerization was carried out in the aqueous medium by using MBP/CuBr/bpy as initiator. The results were characterized by dynamic light scattering (DLS), transmission electron microscope (TEM), and gel permeation chromatography (GPC). It was observed that the stable particles exhibited amphoteric pH sensitivity, namely that in the range of pH 3.0 to 5.0, the particles precipitated, whereas beyond the range the particles were stable and swollen as pH varied. Moreover, the pH range was variable according to the molecular weight of PVP. The results of GPC indicated that the molecular weight of template polymer PMAA was duplicated by the daughter polymer PVP. Being noncross-linked, unlike the common microgels, the hydrodynamic diameter dramatically increased in a very narrow pH range, e.g., pH 5.5 –6 and 2.0–2.5. Finally, the nanoparticles of PMAA/PVP were applied for the controlled release of rifampicin (RFP) and doxorubicin (DOX). |
| doi_str_mv | 10.1007/s00396-015-3554-3 |
| format | Article |
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N
-vinyl pyrrolidone (N-VP) as monomer, the ATRP-template miniemulsion polymerization was carried out in the aqueous medium by using MBP/CuBr/bpy as initiator. The results were characterized by dynamic light scattering (DLS), transmission electron microscope (TEM), and gel permeation chromatography (GPC). It was observed that the stable particles exhibited amphoteric pH sensitivity, namely that in the range of pH 3.0 to 5.0, the particles precipitated, whereas beyond the range the particles were stable and swollen as pH varied. Moreover, the pH range was variable according to the molecular weight of PVP. The results of GPC indicated that the molecular weight of template polymer PMAA was duplicated by the daughter polymer PVP. Being noncross-linked, unlike the common microgels, the hydrodynamic diameter dramatically increased in a very narrow pH range, e.g., pH 5.5 –6 and 2.0–2.5. Finally, the nanoparticles of PMAA/PVP were applied for the controlled release of rifampicin (RFP) and doxorubicin (DOX).</description><identifier>ISSN: 0303-402X</identifier><identifier>EISSN: 1435-1536</identifier><identifier>DOI: 10.1007/s00396-015-3554-3</identifier><language>eng</language><publisher>Berlin/Heidelberg: Springer Berlin Heidelberg</publisher><subject>Characterization and Evaluation of Materials ; Chemistry ; Chemistry and Materials Science ; Complex Fluids and Microfluidics ; Food Science ; Nanotechnology and Microengineering ; Original Contribution ; Physical Chemistry ; Polymer Sciences ; Soft and Granular Matter</subject><ispartof>Colloid and polymer science, 2015-07, Vol.293 (7), p.2035-2044</ispartof><rights>Springer-Verlag Berlin Heidelberg 2015</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c423t-146c72996cd56ebc0a5264ef5ce9d430d28f8e7781bdef9a41e23110712b5c7d3</citedby><cites>FETCH-LOGICAL-c423t-146c72996cd56ebc0a5264ef5ce9d430d28f8e7781bdef9a41e23110712b5c7d3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s00396-015-3554-3$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s00396-015-3554-3$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,780,784,27924,27925,41488,42557,51319</link.rule.ids></links><search><creatorcontrib>Chen, Guoxia</creatorcontrib><creatorcontrib>Liu, Junxiu</creatorcontrib><creatorcontrib>Yang, Yadong</creatorcontrib><creatorcontrib>Zhang, Lijuan</creatorcontrib><creatorcontrib>Wu, Min</creatorcontrib><creatorcontrib>Ni, Henmei</creatorcontrib><title>Preparation of pH-sensitive nanoparticles of poly (methacrylic acid) (PMAA)/poly (vinyl pyrrolidone) (PVP) by ATRP-template miniemulsion polymerization in the aqueous solution</title><title>Colloid and polymer science</title><addtitle>Colloid Polym Sci</addtitle><description>Employing polymethacrylic acid (PMAA) as the template and
N
-vinyl pyrrolidone (N-VP) as monomer, the ATRP-template miniemulsion polymerization was carried out in the aqueous medium by using MBP/CuBr/bpy as initiator. The results were characterized by dynamic light scattering (DLS), transmission electron microscope (TEM), and gel permeation chromatography (GPC). It was observed that the stable particles exhibited amphoteric pH sensitivity, namely that in the range of pH 3.0 to 5.0, the particles precipitated, whereas beyond the range the particles were stable and swollen as pH varied. Moreover, the pH range was variable according to the molecular weight of PVP. The results of GPC indicated that the molecular weight of template polymer PMAA was duplicated by the daughter polymer PVP. Being noncross-linked, unlike the common microgels, the hydrodynamic diameter dramatically increased in a very narrow pH range, e.g., pH 5.5 –6 and 2.0–2.5. Finally, the nanoparticles of PMAA/PVP were applied for the controlled release of rifampicin (RFP) and doxorubicin (DOX).</description><subject>Characterization and Evaluation of Materials</subject><subject>Chemistry</subject><subject>Chemistry and Materials Science</subject><subject>Complex Fluids and Microfluidics</subject><subject>Food Science</subject><subject>Nanotechnology and Microengineering</subject><subject>Original Contribution</subject><subject>Physical Chemistry</subject><subject>Polymer Sciences</subject><subject>Soft and Granular Matter</subject><issn>0303-402X</issn><issn>1435-1536</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2015</creationdate><recordtype>article</recordtype><sourceid>AFKRA</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><recordid>eNp1Uctu1DAUtRBIDIUPYGeJTWfh1o4fmSxHFaVIRYxQW7GzPM4NdeXYwXYqpT_FL5I0LNh0daV7ntJB6COjZ4zS-jxTyhtFKJOESykIf4U2THBJmOTqNdpQTjkRtPr5Fr3L-YFSKhqlNujPIcFgkikuBhw7PFyRDCG74h4BBxPiDBZnPeRnNPoJn_ZQ7o1Nk3cWG-vaLT49fNvvt-cr_OjC5PEwpRS9a2OABb87bPFxwvubHwdSoB-8KYB7Fxz0o89L-CLuIbmntYsLuNwDNr9HiGPGOfpx-b9HbzrjM3z4d0_Q7eXnm4srcv39y9eL_TWxouKFMKFsXTWNsq1UcLTUyEoJ6KSFphWcttWu20Fd79ixha4xgkHFGaM1q47S1i0_QZ9W3yHFuUIu-iGOKcyRmqmG8UYIqWYWW1k2xZwTdHpIrjdp0ozqZRe97qLnXfSyi-azplo1eeaGX5D-c35R9BdMTJMK</recordid><startdate>20150701</startdate><enddate>20150701</enddate><creator>Chen, Guoxia</creator><creator>Liu, Junxiu</creator><creator>Yang, Yadong</creator><creator>Zhang, Lijuan</creator><creator>Wu, Min</creator><creator>Ni, Henmei</creator><general>Springer Berlin Heidelberg</general><general>Springer Nature B.V</general><scope>AAYXX</scope><scope>CITATION</scope><scope>7SR</scope><scope>8FD</scope><scope>8FE</scope><scope>8FG</scope><scope>ABJCF</scope><scope>AFKRA</scope><scope>BENPR</scope><scope>BGLVJ</scope><scope>CCPQU</scope><scope>D1I</scope><scope>DWQXO</scope><scope>HCIFZ</scope><scope>JG9</scope><scope>KB.</scope><scope>PDBOC</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope></search><sort><creationdate>20150701</creationdate><title>Preparation of pH-sensitive nanoparticles of poly (methacrylic acid) (PMAA)/poly (vinyl pyrrolidone) (PVP) by ATRP-template miniemulsion polymerization in the aqueous solution</title><author>Chen, Guoxia ; 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N
-vinyl pyrrolidone (N-VP) as monomer, the ATRP-template miniemulsion polymerization was carried out in the aqueous medium by using MBP/CuBr/bpy as initiator. The results were characterized by dynamic light scattering (DLS), transmission electron microscope (TEM), and gel permeation chromatography (GPC). It was observed that the stable particles exhibited amphoteric pH sensitivity, namely that in the range of pH 3.0 to 5.0, the particles precipitated, whereas beyond the range the particles were stable and swollen as pH varied. Moreover, the pH range was variable according to the molecular weight of PVP. The results of GPC indicated that the molecular weight of template polymer PMAA was duplicated by the daughter polymer PVP. Being noncross-linked, unlike the common microgels, the hydrodynamic diameter dramatically increased in a very narrow pH range, e.g., pH 5.5 –6 and 2.0–2.5. Finally, the nanoparticles of PMAA/PVP were applied for the controlled release of rifampicin (RFP) and doxorubicin (DOX).</abstract><cop>Berlin/Heidelberg</cop><pub>Springer Berlin Heidelberg</pub><doi>10.1007/s00396-015-3554-3</doi><tpages>10</tpages></addata></record> |
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| subjects | Characterization and Evaluation of Materials Chemistry Chemistry and Materials Science Complex Fluids and Microfluidics Food Science Nanotechnology and Microengineering Original Contribution Physical Chemistry Polymer Sciences Soft and Granular Matter |
| title | Preparation of pH-sensitive nanoparticles of poly (methacrylic acid) (PMAA)/poly (vinyl pyrrolidone) (PVP) by ATRP-template miniemulsion polymerization in the aqueous solution |
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