Concise Synthesis of All Stereoisomers of Dendroamide A by Fluorous Mixture Synthesis Based on Fluorous-Fmoc Protection of Amino Acids

A liquid‐phase split‐type synthesis of all the stereoisomers of dendroamide A, which exhibits multidrug‐resistance reversing activity, has been carried out. The key to the concise synthesis was the fluorous‐Fmoc protection strategy of each of the starting materials (D‐ and L‐alanine and D‐ and L‐val...

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Veröffentlicht in:	European journal of organic chemistry 2015-06, Vol.2015 (18), p.3971-3982
Hauptverfasser:	Takahashi, Hiroaki, Endo, Natsuki, Takanose, Hitomi, Sugiyama, Yuya, Eguchi, Fumitaka, Oguri, Kazuma, Hamamoto, Hiromi, Shioiri, Takayuki, Matsugi, Masato
Format:	Artikel
Sprache:	eng
Schlagworte:	Combinatorial chemistry Fluorine Natural products Synthetic methods Total synthesis
Online-Zugang:	Volltext
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