Decreased H2B monoubiquitination and overexpression of ubiquitin-specific protease enzyme 22 in malignant colon carcinoma

Summary This study aimed to evaluate the expression of H2B monoubiquitination enzyme (uH2B) and ubiquitin-specific protease enzyme 22 (USP22) in colon carcinoma and establish a correlation between the expression of these enzymes and clinicopathological parameters. The modification levels of uH2B and...

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Veröffentlicht in:	Human pathology 2015-07, Vol.46 (7), p.1006-1014
Hauptverfasser:	Wang, Zijing, MSc, Zhu, Linlin, MSc, Guo, Tianjiao, MSc, Wang, Yiping, MD, Yang, Jinlin, MD
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Aged Aged, 80 and over Biomarkers, Tumor - analysis Carcinoma - enzymology Carcinoma - mortality Carcinoma - secondary Case-Control Studies Cell Differentiation Chromatin Colon carcinoma Colonic Neoplasms - enzymology Colonic Neoplasms - mortality Colonic Neoplasms - pathology Colorectal cancer DNA methylation Epigenetics Female H2B monoubiqutination Histones - analysis Humans Immunohistochemistry Kaplan-Meier Estimate Lymphatic Metastasis Male Middle Aged Multivariate Analysis Mutation Neoplasm Invasiveness Neoplasm Staging Pathology Predictive Value of Tests Proportional Hazards Models Thiolester Hydrolases - analysis Ubiquitination USP22 Young Adult
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