Adenosine A2a receptor stimulation prevents proteinuria in diabetic rats by promoting an anti-inflammatory phenotype without affecting oxidative stress

Aim Diabetic patients are at increased risk for kidney disease. There is presently no clinical treatment available that effectively protects kidney function in diabetics. This study investigates whether chronic stimulation of the adenosine A2a receptor (A2aAR) protects kidney function in insulinopen...

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Veröffentlicht in:	Acta Physiologica 2015-07, Vol.214 (3), p.311-318
Hauptverfasser:	Persson, P., Friederich-Persson, M., Fasching, A., Hansell, P., Inagi, R., Palm, F.
Format:	Artikel
Sprache:	eng
Schlagworte:	CGS21680 Diabetes diabetes mellitus diabetic nephropathy Genotype & phenotype Hypoxia kidney macrophages Oxidative stress Rodents Studies tumour necrosis factor-alpha
Online-Zugang:	Volltext
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