Oleanolic acid - an [alpha] -Glucosidase inhibitory and antihyperglycemic active compound from the fruits of Sonneratia caseolaris

Oleanolic acid - an [alpha] -Glucosidase inhibitory and antihyperglycemic active compound from the fruits of Sonneratia caseolaris

Fruits of Sonneratia caseolaris Linn. have many therapeutic applications in folklore medicine. However, chemical examination and biological activity of its fruit are less studied. During the work on identification of antidiabetic principles from Indian mangrove flora, we noticed moderate intestinal...

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Veröffentlicht in:Open access journal of medicinal and aromatic plants 2010-01, Vol.1 (1), p.19
Hauptverfasser: Tiwari, Ashok Kumar, Viswanadh, V, Gowri, Ponnapalli Mangala, Ali, Amtul Zehra, Radhakrishnan, SVS, Agawane, Sachin Bharat, Madhusudana, K, Rao, Janaswamy Madhusudana
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Flowers & plants
Fruits
Herbal medicine
Studies
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container_title Open access journal of medicinal and aromatic plants
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creator Tiwari, Ashok Kumar
Viswanadh, V
Gowri, Ponnapalli Mangala
Ali, Amtul Zehra
Radhakrishnan, SVS
Agawane, Sachin Bharat
Madhusudana, K
Rao, Janaswamy Madhusudana
description Fruits of Sonneratia caseolaris Linn. have many therapeutic applications in folklore medicine. However, chemical examination and biological activity of its fruit are less studied. During the work on identification of antidiabetic principles from Indian mangrove flora, we noticed moderate intestinal ? -glucosidase inhibitory activity of the methanolic extract of its fruits. Three compounds namely oleanolic acid, ? -sistosterol- ? -D-glucopyranoside and luteolin were isolated and identified from the bioactive methanolic extract. In vitro pre-incubation of crude rat intestinal ? -glucosidase with oleanolic acid showed potent ? -glucosidase inhibitory (IC50 = 15 ? M) activity, however, its inhibitory potential decreased drastically when oleanolic acid was pre-incubated with substrate. In in vivo studies also, pretreatment of rats with oleanolic acid displayed significant (p
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However, chemical examination and biological activity of its fruit are less studied. During the work on identification of antidiabetic principles from Indian mangrove flora, we noticed moderate intestinal ? -glucosidase inhibitory activity of the methanolic extract of its fruits. Three compounds namely oleanolic acid, ? -sistosterol- ? -D-glucopyranoside and luteolin were isolated and identified from the bioactive methanolic extract. In vitro pre-incubation of crude rat intestinal ? -glucosidase with oleanolic acid showed potent ? -glucosidase inhibitory (IC50 = 15 ? M) activity, however, its inhibitory potential decreased drastically when oleanolic acid was pre-incubated with substrate. In in vivo studies also, pretreatment of rats with oleanolic acid displayed significant (p&lt;0.05) antihyperglycemic activity in starch tolerance test however, administration of starch fortified with oleanolic acid to the rats could not exhibit antihyperglycemic activity. 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subjects Flowers & plants
Fruits
Herbal medicine
Studies
title Oleanolic acid - an [alpha] -Glucosidase inhibitory and antihyperglycemic active compound from the fruits of Sonneratia caseolaris
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