Co-endemicity of Loiasis and Onchocerciasis in Rain Forest Communities in Southwestern Nigeria: e0003633
Background Loiasis is currently receiving attention as a disease of public health importance because of the possibility of increased risk of developing neurologic serious adverse event following mass ivermectin treatment against onchocerciasis in individual co-infected with Onchocerca volvulus and L...
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| Veröffentlicht in: | PLoS neglected tropical diseases 2015-03, Vol.9 (3) |
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| creator | Ojurongbe, Olusola Akindele, Akeem Abiodun Adeleke, Monsuru Adebayo Oyedeji, Matthew Oyebode Adedokun, Samuel Adeyinka Ojo, Josephine Folashade Akinleye, Callistus Adewale Bolaji, Oloyede Samuel Adefioye, Olusegun Adelowo Adeyeba, Oluwaseyi Adegboyega |
| description | Background Loiasis is currently receiving attention as a disease of public health importance because of the possibility of increased risk of developing neurologic serious adverse event following mass ivermectin treatment against onchocerciasis in individual co-infected with Onchocerca volvulus and Loa loa. Methodology/Principal Findings Rapid assessment procedure for loiasis (RAPLOA) was conducted in 12 communities covering the 3 senatorial districts of Osun State, Nigeria. A total of 960 people were interviewed for history of eye worm using the WHO guidelines for rapid assessment. The survey confirmed the presence of loiasis in all the 12 communities with 4 in Osun East/Ife south senatorial district being at high risk with a prevalence of over 40%. Based on the RAPLOA results, communities within Osun East/Ife south senatorial district were selected for microfilaraemic assessment of L. loa and O. volvulus. A total of 1115 and 1091 individuals were screened for L. loa and O. volvulus microfilaria worms respectively. 160 (14.3%) had L. loa microfilaria detected in their blood with 8 (5.0%) individuals having L. loa loads above 8000 mf/ml. 166 (15.2%) subjects had O. volvulus microfilaria (range 4-504 mf/ml) detected in their skin snip. 30 (2.69%) subjects were co-infected with both L. loa and O. volvulus. There was a significant variation in the prevalence (2.1% to 33.3%) of onchocerciasis in the communities studied (p = 0.001). Five (41.7%) of the studied communities had a prevalence that is equal to or greater than 20%. Conclusions/Significance Low prevalence of onchocerciasis and loiasis co-infection in this study suggests that loiasis may not pose a serious epidemiological threat to the continuous distribution and sustainability of ivermectin for the treatment of onchocerciasis. Evaluation of the interruption of onchocerciasis transmissions in this region using all the indicators set forth by WHO is therefore suggested. |
| doi_str_mv | 10.1371/journal.pntd.0003633 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest</sourceid><recordid>TN_cdi_proquest_journals_1685627768</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>3703940091</sourcerecordid><originalsourceid>FETCH-proquest_journals_16856277683</originalsourceid><addsrcrecordid>eNqNjjFrwzAUhEVJIGnSf5BB0NmuZCHLnk1Dh5JAkzlB2HL9jK3nSjIh_76mCZ2z3B333XCEbDiLuVD8rcXRWd3Fgw1VzBgTqRBPZMlzIaNECTn7z4lakGfvW8ZkLjO-JKcCI2Mr00MJ4Uqxpp8I2oOn2lZ0b8sGS-PKWwWWfulJtuiMD7TAvh8tBDB_6IBjaC4TMM7SHXwbB3pN5rXuvHm5-4q8bt-PxUc0OPwZp-35_t2feZrJNFEqzcRjq18MWk29</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1685627768</pqid></control><display><type>article</type><title>Co-endemicity of Loiasis and Onchocerciasis in Rain Forest Communities in Southwestern Nigeria: e0003633</title><source>DOAJ Directory of Open Access Journals</source><source>PubMed Central Open Access</source><source>Public Library of Science (PLoS) Journals Open Access</source><source>EZB-FREE-00999 freely available EZB journals</source><source>PubMed Central</source><creator>Ojurongbe, Olusola ; Akindele, Akeem Abiodun ; Adeleke, Monsuru Adebayo ; Oyedeji, Matthew Oyebode ; Adedokun, Samuel Adeyinka ; Ojo, Josephine Folashade ; Akinleye, Callistus Adewale ; Bolaji, Oloyede Samuel ; Adefioye, Olusegun Adelowo ; Adeyeba, Oluwaseyi Adegboyega</creator><creatorcontrib>Ojurongbe, Olusola ; Akindele, Akeem Abiodun ; Adeleke, Monsuru Adebayo ; Oyedeji, Matthew Oyebode ; Adedokun, Samuel Adeyinka ; Ojo, Josephine Folashade ; Akinleye, Callistus Adewale ; Bolaji, Oloyede Samuel ; Adefioye, Olusegun Adelowo ; Adeyeba, Oluwaseyi Adegboyega</creatorcontrib><description>Background Loiasis is currently receiving attention as a disease of public health importance because of the possibility of increased risk of developing neurologic serious adverse event following mass ivermectin treatment against onchocerciasis in individual co-infected with Onchocerca volvulus and Loa loa. Methodology/Principal Findings Rapid assessment procedure for loiasis (RAPLOA) was conducted in 12 communities covering the 3 senatorial districts of Osun State, Nigeria. A total of 960 people were interviewed for history of eye worm using the WHO guidelines for rapid assessment. The survey confirmed the presence of loiasis in all the 12 communities with 4 in Osun East/Ife south senatorial district being at high risk with a prevalence of over 40%. Based on the RAPLOA results, communities within Osun East/Ife south senatorial district were selected for microfilaraemic assessment of L. loa and O. volvulus. A total of 1115 and 1091 individuals were screened for L. loa and O. volvulus microfilaria worms respectively. 160 (14.3%) had L. loa microfilaria detected in their blood with 8 (5.0%) individuals having L. loa loads above 8000 mf/ml. 166 (15.2%) subjects had O. volvulus microfilaria (range 4-504 mf/ml) detected in their skin snip. 30 (2.69%) subjects were co-infected with both L. loa and O. volvulus. There was a significant variation in the prevalence (2.1% to 33.3%) of onchocerciasis in the communities studied (p = 0.001). Five (41.7%) of the studied communities had a prevalence that is equal to or greater than 20%. Conclusions/Significance Low prevalence of onchocerciasis and loiasis co-infection in this study suggests that loiasis may not pose a serious epidemiological threat to the continuous distribution and sustainability of ivermectin for the treatment of onchocerciasis. Evaluation of the interruption of onchocerciasis transmissions in this region using all the indicators set forth by WHO is therefore suggested.</description><identifier>ISSN: 1935-2727</identifier><identifier>EISSN: 1935-2735</identifier><identifier>DOI: 10.1371/journal.pntd.0003633</identifier><language>eng</language><publisher>San Francisco: Public Library of Science</publisher><subject>Disease ; Forest communities ; Infections ; Older people ; Public health ; Rainforests ; Sustainability ; Tropical diseases</subject><ispartof>PLoS neglected tropical diseases, 2015-03, Vol.9 (3)</ispartof><rights>2015 Public Library of Science. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited: Ojurongbe O, Akindele AA, Adeleke MA, Oyedeji MO, Adedokun SA, Ojo JF, et al. (2015) Co-endemicity of Loiasis and Onchocerciasis in Rain Forest Communities in Southwestern Nigeria. 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Methodology/Principal Findings Rapid assessment procedure for loiasis (RAPLOA) was conducted in 12 communities covering the 3 senatorial districts of Osun State, Nigeria. A total of 960 people were interviewed for history of eye worm using the WHO guidelines for rapid assessment. The survey confirmed the presence of loiasis in all the 12 communities with 4 in Osun East/Ife south senatorial district being at high risk with a prevalence of over 40%. Based on the RAPLOA results, communities within Osun East/Ife south senatorial district were selected for microfilaraemic assessment of L. loa and O. volvulus. A total of 1115 and 1091 individuals were screened for L. loa and O. volvulus microfilaria worms respectively. 160 (14.3%) had L. loa microfilaria detected in their blood with 8 (5.0%) individuals having L. loa loads above 8000 mf/ml. 166 (15.2%) subjects had O. volvulus microfilaria (range 4-504 mf/ml) detected in their skin snip. 30 (2.69%) subjects were co-infected with both L. loa and O. volvulus. There was a significant variation in the prevalence (2.1% to 33.3%) of onchocerciasis in the communities studied (p = 0.001). Five (41.7%) of the studied communities had a prevalence that is equal to or greater than 20%. Conclusions/Significance Low prevalence of onchocerciasis and loiasis co-infection in this study suggests that loiasis may not pose a serious epidemiological threat to the continuous distribution and sustainability of ivermectin for the treatment of onchocerciasis. Evaluation of the interruption of onchocerciasis transmissions in this region using all the indicators set forth by WHO is therefore suggested.</description><subject>Disease</subject><subject>Forest communities</subject><subject>Infections</subject><subject>Older people</subject><subject>Public health</subject><subject>Rainforests</subject><subject>Sustainability</subject><subject>Tropical diseases</subject><issn>1935-2727</issn><issn>1935-2735</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2015</creationdate><recordtype>article</recordtype><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><recordid>eNqNjjFrwzAUhEVJIGnSf5BB0NmuZCHLnk1Dh5JAkzlB2HL9jK3nSjIh_76mCZ2z3B333XCEbDiLuVD8rcXRWd3Fgw1VzBgTqRBPZMlzIaNECTn7z4lakGfvW8ZkLjO-JKcCI2Mr00MJ4Uqxpp8I2oOn2lZ0b8sGS-PKWwWWfulJtuiMD7TAvh8tBDB_6IBjaC4TMM7SHXwbB3pN5rXuvHm5-4q8bt-PxUc0OPwZp-35_t2feZrJNFEqzcRjq18MWk29</recordid><startdate>20150301</startdate><enddate>20150301</enddate><creator>Ojurongbe, Olusola</creator><creator>Akindele, Akeem Abiodun</creator><creator>Adeleke, Monsuru Adebayo</creator><creator>Oyedeji, Matthew Oyebode</creator><creator>Adedokun, Samuel Adeyinka</creator><creator>Ojo, Josephine Folashade</creator><creator>Akinleye, Callistus Adewale</creator><creator>Bolaji, Oloyede Samuel</creator><creator>Adefioye, Olusegun Adelowo</creator><creator>Adeyeba, Oluwaseyi Adegboyega</creator><general>Public Library of Science</general><scope>3V.</scope><scope>7QL</scope><scope>7SS</scope><scope>7T2</scope><scope>7T7</scope><scope>7U9</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8C1</scope><scope>8FD</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>C1K</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>F1W</scope><scope>FR3</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>H94</scope><scope>H95</scope><scope>H97</scope><scope>K9.</scope><scope>L.G</scope><scope>M0S</scope><scope>M1P</scope><scope>M7N</scope><scope>P64</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope></search><sort><creationdate>20150301</creationdate><title>Co-endemicity of Loiasis and Onchocerciasis in Rain Forest Communities in Southwestern Nigeria</title><author>Ojurongbe, Olusola ; Akindele, Akeem Abiodun ; Adeleke, Monsuru Adebayo ; Oyedeji, Matthew Oyebode ; Adedokun, Samuel Adeyinka ; Ojo, Josephine Folashade ; Akinleye, Callistus Adewale ; Bolaji, Oloyede Samuel ; Adefioye, Olusegun Adelowo ; Adeyeba, Oluwaseyi Adegboyega</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-proquest_journals_16856277683</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2015</creationdate><topic>Disease</topic><topic>Forest communities</topic><topic>Infections</topic><topic>Older people</topic><topic>Public health</topic><topic>Rainforests</topic><topic>Sustainability</topic><topic>Tropical diseases</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Ojurongbe, Olusola</creatorcontrib><creatorcontrib>Akindele, Akeem Abiodun</creatorcontrib><creatorcontrib>Adeleke, Monsuru Adebayo</creatorcontrib><creatorcontrib>Oyedeji, Matthew Oyebode</creatorcontrib><creatorcontrib>Adedokun, Samuel Adeyinka</creatorcontrib><creatorcontrib>Ojo, Josephine Folashade</creatorcontrib><creatorcontrib>Akinleye, Callistus Adewale</creatorcontrib><creatorcontrib>Bolaji, Oloyede Samuel</creatorcontrib><creatorcontrib>Adefioye, Olusegun Adelowo</creatorcontrib><creatorcontrib>Adeyeba, Oluwaseyi Adegboyega</creatorcontrib><collection>ProQuest Central (Corporate)</collection><collection>Bacteriology Abstracts (Microbiology B)</collection><collection>Entomology Abstracts (Full archive)</collection><collection>Health and Safety Science Abstracts (Full archive)</collection><collection>Industrial and Applied Microbiology Abstracts (Microbiology A)</collection><collection>Virology and AIDS Abstracts</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Public Health Database</collection><collection>Technology Research Database</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>ProQuest Central</collection><collection>Environmental Sciences and Pollution Management</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>ASFA: Aquatic Sciences and Fisheries Abstracts</collection><collection>Engineering Research Database</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>Aquatic Science & Fisheries Abstracts (ASFA) 1: Biological Sciences & Living Resources</collection><collection>Aquatic Science & Fisheries Abstracts (ASFA) 3: Aquatic Pollution & Environmental Quality</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Aquatic Science & Fisheries Abstracts (ASFA) Professional</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Algology Mycology and Protozoology Abstracts (Microbiology C)</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>Access via ProQuest (Open Access)</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><jtitle>PLoS neglected tropical diseases</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Ojurongbe, Olusola</au><au>Akindele, Akeem Abiodun</au><au>Adeleke, Monsuru Adebayo</au><au>Oyedeji, Matthew Oyebode</au><au>Adedokun, Samuel Adeyinka</au><au>Ojo, Josephine Folashade</au><au>Akinleye, Callistus Adewale</au><au>Bolaji, Oloyede Samuel</au><au>Adefioye, Olusegun Adelowo</au><au>Adeyeba, Oluwaseyi Adegboyega</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Co-endemicity of Loiasis and Onchocerciasis in Rain Forest Communities in Southwestern Nigeria: e0003633</atitle><jtitle>PLoS neglected tropical diseases</jtitle><date>2015-03-01</date><risdate>2015</risdate><volume>9</volume><issue>3</issue><issn>1935-2727</issn><eissn>1935-2735</eissn><abstract>Background Loiasis is currently receiving attention as a disease of public health importance because of the possibility of increased risk of developing neurologic serious adverse event following mass ivermectin treatment against onchocerciasis in individual co-infected with Onchocerca volvulus and Loa loa. Methodology/Principal Findings Rapid assessment procedure for loiasis (RAPLOA) was conducted in 12 communities covering the 3 senatorial districts of Osun State, Nigeria. A total of 960 people were interviewed for history of eye worm using the WHO guidelines for rapid assessment. The survey confirmed the presence of loiasis in all the 12 communities with 4 in Osun East/Ife south senatorial district being at high risk with a prevalence of over 40%. Based on the RAPLOA results, communities within Osun East/Ife south senatorial district were selected for microfilaraemic assessment of L. loa and O. volvulus. A total of 1115 and 1091 individuals were screened for L. loa and O. volvulus microfilaria worms respectively. 160 (14.3%) had L. loa microfilaria detected in their blood with 8 (5.0%) individuals having L. loa loads above 8000 mf/ml. 166 (15.2%) subjects had O. volvulus microfilaria (range 4-504 mf/ml) detected in their skin snip. 30 (2.69%) subjects were co-infected with both L. loa and O. volvulus. There was a significant variation in the prevalence (2.1% to 33.3%) of onchocerciasis in the communities studied (p = 0.001). Five (41.7%) of the studied communities had a prevalence that is equal to or greater than 20%. Conclusions/Significance Low prevalence of onchocerciasis and loiasis co-infection in this study suggests that loiasis may not pose a serious epidemiological threat to the continuous distribution and sustainability of ivermectin for the treatment of onchocerciasis. Evaluation of the interruption of onchocerciasis transmissions in this region using all the indicators set forth by WHO is therefore suggested.</abstract><cop>San Francisco</cop><pub>Public Library of Science</pub><doi>10.1371/journal.pntd.0003633</doi><oa>free_for_read</oa></addata></record> |
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| subjects | Disease Forest communities Infections Older people Public health Rainforests Sustainability Tropical diseases |
| title | Co-endemicity of Loiasis and Onchocerciasis in Rain Forest Communities in Southwestern Nigeria: e0003633 |
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