Structure of the Trehalose-6-phosphate Phosphatase from Brugia malayi Reveals Key Design Principles for Anthelmintic Drugs: e1004245

Parasitic nematodes are responsible for devastating illnesses that plague many of the world's poorest populations indigenous to the tropical areas of developing nations. Among these diseases is lymphatic filariasis, a major cause of permanent and long-term disability. Proteins essential to nema...

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Veröffentlicht in:	PLoS pathogens 2014-07, Vol.10 (7)
Hauptverfasser:	Farelli, Jeremiah D, Galvin, Brendan D, Li, Zhiru, Liu, Chunliang, Aono, Miyuki, Garland, Megan, Hallett, Olivia E, Causey, Thomas B, Ali-Reynolds, Alana, Saltzberg, Daniel J, Carlow, Clotilde KS, Dunaway-Mariano, Debra, Allen, Karen N
Format:	Artikel
Sprache:	eng
Schlagworte:	Catalysis Drug resistance Enzymes Infections Mutagenesis Nematodes Phosphatase Principles Proteins Tropical diseases Tuberculosis
Online-Zugang:	Volltext
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