Differential Inhibition of Human Atherosclerotic Plaque–Induced Platelet Activation by Dimeric GPVI-Fc and Anti-GPVI Antibodies

Abstract Background Glycoprotein VI (GPVI) is the essential platelet collagen receptor in atherothrombosis, but its inhibition causes only a mild bleeding tendency. Thus, targeting this receptor has selective antithrombotic potential. Objectives This study sought to compare compounds interfering wit...

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Veröffentlicht in:	Journal of the American College of Cardiology 2015-06, Vol.65 (22), p.2404-2415
Hauptverfasser:	Jamasbi, Janina, RPh, Megens, Remco T.A., PhD, Bianchini, Mariaelvy, MSc, Münch, Götz, MD, Ungerer, Martin, MD, Faussner, Alexander, PhD, Sherman, Shachar, BSc, Walker, Adam, PhD, Goyal, Pankaj, PhD, Jung, Stephanie, PhD, Brandl, Richard, MD, Weber, Christian, MD, Lorenz, Reinhard, MD, Farndale, Richard, PhD, Elia, Natalie, PhD, Siess, Wolfgang, MD
Format:	Artikel
Sprache:	eng
Schlagworte:	antithrombotic atherothrombosis Binding sites Blood platelets Cardiology Cardiovascular Collagen Experiments glycoprotein VI Internal Medicine Peptides plaque rupture Proteins Studies Thrombosis Wound healing
Online-Zugang:	Volltext
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