During Drosophila disc regeneration, JAK/STAT coordinates cell proliferation with Dilp8-mediated developmental delay

Significance The larval imaginal discs of the fruit fly are capable of fully regenerating mechanically damaged parts. Wound healing is initiated by the JNK signaling pathway. We followed the subsequent formation of the regenerating blastema by transcriptome profiling and identified the JAK/STAT path...

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Veröffentlicht in:	Proceedings of the National Academy of Sciences - PNAS 2015-05, Vol.112 (18), p.E2327-E2336
Hauptverfasser:	Katsuyama, Tomonori, Comoglio, Federico, Seimiya, Makiko, Cabuy, Erik, Paro, Renato
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Biological Sciences Body Patterning Cell growth Cell Lineage Cell Proliferation Cluster Analysis Drosophila Drosophila - physiology Drosophila Proteins - metabolism Gene Expression Regulation Imaginal Discs - physiology Insects Insulin Intercellular Signaling Peptides and Proteins - metabolism Janus Kinases - metabolism Oligonucleotide Array Sequence Analysis Peptides PNAS Plus Principal Component Analysis Regeneration Signal Transduction STAT Transcription Factors - metabolism Transcription factors Transcription Factors - metabolism Transcriptome Wound Healing
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