Integrin [alpha]v[beta]8-Mediated TGF-[beta] Activation by Effector Regulatory T Cells Is Essential for Suppression of T-Cell-Mediated Inflammation

Regulatory T (Treg) cells play a pivotal role in suppressing self-harmful T cell responses, but how Treg cells mediate suppression to maintain immune homeostasis and limit responses during inflammation is unclear. Here we show that effector Treg cells express high amounts of the integrin [alpha]vβ8,...

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Veröffentlicht in:	Immunity (Cambridge, Mass.) Mass.), 2015-05, Vol.42 (5), p.903
Hauptverfasser:	Worthington, John J, Kelly, Aoife, Smedley, Catherine, Bauché, David, Campbell, Simon, Marie, Julien C, Travis, Mark A
Format:	Artikel
Sprache:	eng
Schlagworte:	Colleges & universities Cytokines Flow cytometry Homeostasis Inflammatory bowel disease Lymphocytes
Online-Zugang:	Volltext
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