Novel methodology for labelling mesoporous silica nanoparticles using the ^sup 18^F isotope and their in vivo biodistribution by positron emission tomography
Nanoparticles have been proposed for several biomedical applications due to their potential as drug carriers, diagnostic and therapeutic agents. However, only a few of them have been approved for their use in humans. In order to gauge the potential applicability of a specific type of nanoparticle, i...
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| Veröffentlicht in: | Journal of nanoparticle research : an interdisciplinary forum for nanoscale science and technology 2015-03, Vol.17 (3), p.1 |
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| container_title | Journal of nanoparticle research : an interdisciplinary forum for nanoscale science and technology |
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| creator | Rojas, Santiago Gispert, Juan Domingo Menchón, Cristina Baldoví, Herme G Buaki-sogo, Mireia Rocha, Milagros Abad, Sergio Victor, Victor Manuel García, Hermenegildo Herance, José Raúl |
| description | Nanoparticles have been proposed for several biomedical applications due to their potential as drug carriers, diagnostic and therapeutic agents. However, only a few of them have been approved for their use in humans. In order to gauge the potential applicability of a specific type of nanoparticle, in vivo biodistribution studies to characterize their pharmacokinetic properties are essential. In this regard, mesoporous silica nanoparticles (30-130 nm) have been functionalized with amino groups in order to react with N-succinimidyl 4-[^sup 18^F]fluorobenzoate and thus anchor the ^sup 18^F positron emission isotope by using a novel and easy labelling strategy. In vivo biodistribution was characterized in mice after intravenous administration of radiolabelled nanoparticles by positron emission tomography. Our results indicated that radiolabelled mesoporous silica nanoparticles were excreted into bile and urine and accumulated mainly in the organs of the reticuloendothelial system and lungs. |
| doi_str_mv | 10.1007/s11051-015-2938-0 |
| format | Article |
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| subjects | Emissions Intravenous administration Nanoparticles Pharmacokinetics Silica |
| title | Novel methodology for labelling mesoporous silica nanoparticles using the ^sup 18^F isotope and their in vivo biodistribution by positron emission tomography |
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