25-Hydroxyvitamin D level does not reflect intestinal calcium absorption: an assay using strontium as a surrogate marker
There is conflicting evidence as to the optimal serum 25-hydroxyvitamin D [25(OH)D] concentration for intestinal calcium absorption (Abs-Ca). Our purpose was to assess the relationship between vitamin D status and Abs-Ca in postmenopausal women. Fifty volunteers with low bone mass were grouped accor...
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| Veröffentlicht in: | Journal of bone and mineral metabolism 2015-05, Vol.33 (3), p.319-328 |
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| container_title | Journal of bone and mineral metabolism |
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| creator | Camargo, Marília Brasilio Rodrigues Vilaça, Tatiane Hayashi, Lilian Fukusima Rocha, Olguita G. Ferreira Lazaretti-Castro, Marise |
| description | There is conflicting evidence as to the optimal serum 25-hydroxyvitamin D [25(OH)D] concentration for intestinal calcium absorption (Abs-Ca). Our purpose was to assess the relationship between vitamin D status and Abs-Ca in postmenopausal women. Fifty volunteers with low bone mass were grouped according to their serum 25(OH)D concentration as follows: mild deficient, |
| doi_str_mv | 10.1007/s00774-014-0592-8 |
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2
D] concentrations differed between the groups (SUF vs. DEF) as follows: 98.7 ± 18.2 vs. 38.4 ± 8.5 nmol/L (
p
< 0.001) and 36.2 ± 10.2 vs. 24.9 ± 4.6 pg/mL (
p
< 0.001), respectively. There was no statistically significant difference between the groups for parathyroid hormone and AUC. Only 1,25(OH)
2
D influenced the strontium absorption in the last 2 h of the test. In the studied population, no correlation between levels of 25(OH)D and Abs-Ca was found. Only 1,25(OH)
2
D influenced Abs-Ca as measured by a strontium absorption test.</description><identifier>ISSN: 0914-8779</identifier><identifier>EISSN: 1435-5604</identifier><identifier>DOI: 10.1007/s00774-014-0592-8</identifier><identifier>PMID: 24858975</identifier><language>eng</language><publisher>Tokyo: Springer Japan</publisher><subject>Aged ; Aged, 80 and over ; Anthropometry ; Calcium - metabolism ; Calcium, Dietary - metabolism ; Humans ; Intestinal Absorption ; Medicine ; Medicine & Public Health ; Metabolic Diseases ; Middle Aged ; Original Article ; Orthopedics ; Skin - metabolism ; Strontium - metabolism ; Vitamin D - analogs & derivatives ; Vitamin D - blood ; Vitamin D - metabolism</subject><ispartof>Journal of bone and mineral metabolism, 2015-05, Vol.33 (3), p.319-328</ispartof><rights>The Japanese Society for Bone and Mineral Research and Springer Japan 2014</rights><rights>The Japanese Society for Bone and Mineral Research and Springer Japan 2015</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c429t-7a81326791207b4d848e4a585f9e0db1cfee18902313321229b746b73c32c923</citedby><cites>FETCH-LOGICAL-c429t-7a81326791207b4d848e4a585f9e0db1cfee18902313321229b746b73c32c923</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s00774-014-0592-8$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s00774-014-0592-8$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,780,784,27923,27924,41487,42556,51318</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/24858975$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Camargo, Marília Brasilio Rodrigues</creatorcontrib><creatorcontrib>Vilaça, Tatiane</creatorcontrib><creatorcontrib>Hayashi, Lilian Fukusima</creatorcontrib><creatorcontrib>Rocha, Olguita G. Ferreira</creatorcontrib><creatorcontrib>Lazaretti-Castro, Marise</creatorcontrib><title>25-Hydroxyvitamin D level does not reflect intestinal calcium absorption: an assay using strontium as a surrogate marker</title><title>Journal of bone and mineral metabolism</title><addtitle>J Bone Miner Metab</addtitle><addtitle>J Bone Miner Metab</addtitle><description>There is conflicting evidence as to the optimal serum 25-hydroxyvitamin D [25(OH)D] concentration for intestinal calcium absorption (Abs-Ca). Our purpose was to assess the relationship between vitamin D status and Abs-Ca in postmenopausal women. Fifty volunteers with low bone mass were grouped according to their serum 25(OH)D concentration as follows: mild deficient, <50 nmol/L (DEF) and sufficient, ≥75 nmol/L (SUF). The subjects were submitted to an oral strontium overload test to assess their Abs-Ca. Fasting blood samples were obtained to perform the relevant hormonal and biochemical tests. After the subjects received the test solution, blood samples were drawn at 30, 60, 120, and 240 min to determine the strontium concentrations. Abs-Ca was indirectly expressed as the area under the serum strontium concentration curve (AUC). A repeated measures ANOVA was performed to determine the differences among the groups. Pearson’s correlation and multiple linear regression analysis were used to study the associations between the variables. The mean 25(OH)D and 1,25-dihydroxyvitamin D [1,25(OH)
2
D] concentrations differed between the groups (SUF vs. DEF) as follows: 98.7 ± 18.2 vs. 38.4 ± 8.5 nmol/L (
p
< 0.001) and 36.2 ± 10.2 vs. 24.9 ± 4.6 pg/mL (
p
< 0.001), respectively. There was no statistically significant difference between the groups for parathyroid hormone and AUC. Only 1,25(OH)
2
D influenced the strontium absorption in the last 2 h of the test. In the studied population, no correlation between levels of 25(OH)D and Abs-Ca was found. Only 1,25(OH)
2
D influenced Abs-Ca as measured by a strontium absorption test.</description><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>Anthropometry</subject><subject>Calcium - metabolism</subject><subject>Calcium, Dietary - metabolism</subject><subject>Humans</subject><subject>Intestinal Absorption</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Metabolic Diseases</subject><subject>Middle Aged</subject><subject>Original Article</subject><subject>Orthopedics</subject><subject>Skin - metabolism</subject><subject>Strontium - metabolism</subject><subject>Vitamin D - analogs & derivatives</subject><subject>Vitamin D - blood</subject><subject>Vitamin D - metabolism</subject><issn>0914-8779</issn><issn>1435-5604</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2015</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><recordid>eNp1kMtOAyEUhonRaL08gBtD4nqU6wDujPfExE33hJmhzdQpVA5j7NtLrRo3LoDF-c7POR9Cp5RcUELUJZRLiYrQcqRhld5BEyq4rGRNxC6aEFMqWilzgA4BFoRQJRXdRwdMaKmNkhP0wWT1uO5S_Fi_99kt-4Bv8eDf_YC76AGHmHHys8G3Gfche8h9cANu3dD24xK7BmJa5T6GK-wCdgBujUfowxxDTjHkLwiwwzCmFOcue7x06dWnY7Q3cwP4k-_3CE3v76Y3j9Xzy8PTzfVz1QpmcqWcppzVylBGVCM6LbQXTmo5M550DW1n3lNtCOOUc0YZM40SdaN4y1lrGD9C59vYVYpvYxnfLuKYygpgaa0JJbw2ulB0S7UpApR97Sr1Zc61pcRuVNutaltU241qu-k5-04em6Xvfjt-3BaAbQEopTD36c_X_6Z-AiWFiaY</recordid><startdate>20150501</startdate><enddate>20150501</enddate><creator>Camargo, Marília Brasilio Rodrigues</creator><creator>Vilaça, Tatiane</creator><creator>Hayashi, Lilian Fukusima</creator><creator>Rocha, Olguita G. Ferreira</creator><creator>Lazaretti-Castro, Marise</creator><general>Springer Japan</general><general>Springer Nature B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7QP</scope><scope>7RV</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>K9.</scope><scope>KB0</scope><scope>M0S</scope><scope>M1P</scope><scope>NAPCQ</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope></search><sort><creationdate>20150501</creationdate><title>25-Hydroxyvitamin D level does not reflect intestinal calcium absorption: an assay using strontium as a surrogate marker</title><author>Camargo, Marília Brasilio Rodrigues ; Vilaça, Tatiane ; Hayashi, Lilian Fukusima ; Rocha, Olguita G. Ferreira ; Lazaretti-Castro, Marise</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c429t-7a81326791207b4d848e4a585f9e0db1cfee18902313321229b746b73c32c923</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2015</creationdate><topic>Aged</topic><topic>Aged, 80 and over</topic><topic>Anthropometry</topic><topic>Calcium - metabolism</topic><topic>Calcium, Dietary - metabolism</topic><topic>Humans</topic><topic>Intestinal Absorption</topic><topic>Medicine</topic><topic>Medicine & Public Health</topic><topic>Metabolic Diseases</topic><topic>Middle Aged</topic><topic>Original Article</topic><topic>Orthopedics</topic><topic>Skin - metabolism</topic><topic>Strontium - metabolism</topic><topic>Vitamin D - analogs & derivatives</topic><topic>Vitamin D - blood</topic><topic>Vitamin D - metabolism</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Camargo, Marília Brasilio Rodrigues</creatorcontrib><creatorcontrib>Vilaça, Tatiane</creatorcontrib><creatorcontrib>Hayashi, Lilian Fukusima</creatorcontrib><creatorcontrib>Rocha, Olguita G. Ferreira</creatorcontrib><creatorcontrib>Lazaretti-Castro, Marise</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Calcium & Calcified Tissue Abstracts</collection><collection>Nursing & Allied Health Database</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Database (Alumni Edition)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Nursing & Allied Health Premium</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><jtitle>Journal of bone and mineral metabolism</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Camargo, Marília Brasilio Rodrigues</au><au>Vilaça, Tatiane</au><au>Hayashi, Lilian Fukusima</au><au>Rocha, Olguita G. Ferreira</au><au>Lazaretti-Castro, Marise</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>25-Hydroxyvitamin D level does not reflect intestinal calcium absorption: an assay using strontium as a surrogate marker</atitle><jtitle>Journal of bone and mineral metabolism</jtitle><stitle>J Bone Miner Metab</stitle><addtitle>J Bone Miner Metab</addtitle><date>2015-05-01</date><risdate>2015</risdate><volume>33</volume><issue>3</issue><spage>319</spage><epage>328</epage><pages>319-328</pages><issn>0914-8779</issn><eissn>1435-5604</eissn><abstract>There is conflicting evidence as to the optimal serum 25-hydroxyvitamin D [25(OH)D] concentration for intestinal calcium absorption (Abs-Ca). Our purpose was to assess the relationship between vitamin D status and Abs-Ca in postmenopausal women. Fifty volunteers with low bone mass were grouped according to their serum 25(OH)D concentration as follows: mild deficient, <50 nmol/L (DEF) and sufficient, ≥75 nmol/L (SUF). The subjects were submitted to an oral strontium overload test to assess their Abs-Ca. Fasting blood samples were obtained to perform the relevant hormonal and biochemical tests. After the subjects received the test solution, blood samples were drawn at 30, 60, 120, and 240 min to determine the strontium concentrations. Abs-Ca was indirectly expressed as the area under the serum strontium concentration curve (AUC). A repeated measures ANOVA was performed to determine the differences among the groups. Pearson’s correlation and multiple linear regression analysis were used to study the associations between the variables. The mean 25(OH)D and 1,25-dihydroxyvitamin D [1,25(OH)
2
D] concentrations differed between the groups (SUF vs. DEF) as follows: 98.7 ± 18.2 vs. 38.4 ± 8.5 nmol/L (
p
< 0.001) and 36.2 ± 10.2 vs. 24.9 ± 4.6 pg/mL (
p
< 0.001), respectively. There was no statistically significant difference between the groups for parathyroid hormone and AUC. Only 1,25(OH)
2
D influenced the strontium absorption in the last 2 h of the test. In the studied population, no correlation between levels of 25(OH)D and Abs-Ca was found. Only 1,25(OH)
2
D influenced Abs-Ca as measured by a strontium absorption test.</abstract><cop>Tokyo</cop><pub>Springer Japan</pub><pmid>24858975</pmid><doi>10.1007/s00774-014-0592-8</doi><tpages>10</tpages></addata></record> |
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| subjects | Aged Aged, 80 and over Anthropometry Calcium - metabolism Calcium, Dietary - metabolism Humans Intestinal Absorption Medicine Medicine & Public Health Metabolic Diseases Middle Aged Original Article Orthopedics Skin - metabolism Strontium - metabolism Vitamin D - analogs & derivatives Vitamin D - blood Vitamin D - metabolism |
| title | 25-Hydroxyvitamin D level does not reflect intestinal calcium absorption: an assay using strontium as a surrogate marker |
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