IRX1 hypomethylation promotes osteosarcoma metastasis via induction of CXCL14/NF-[kappa]B signaling

Osteosarcoma is a common malignant bone tumor with a propensity to metastasize to the lungs. Epigenetic abnormalities have been demonstrated to underlie osteosarcoma development; however, the epigenetic mechanisms that are involved in metastasis are not yet clear. Here, we analyzed 2 syngeneic prima...

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Veröffentlicht in:	The Journal of clinical investigation 2015-05, Vol.125 (5), p.1839
Hauptverfasser:	Lu, Jinchang, Song, Guohui, Tang, Qinglian, Zou, Changye, Han, Feng, Zhao, Zhiqiang, Yong, Bicheng, Yin, Junqiang, Xu, Huaiyuan, Xie, Xianbiao, Kang, Tiebang, Lam, YingLee, Yang, Huiling, Shen, Jingnan, Wang, Jin
Format:	Artikel
Sprache:	eng
Schlagworte:	Biomedical research Cell cycle Chemokines DNA methylation Epigenetics Gene expression Lungs Medical prognosis Metastasis Pancreatic cancer Studies Survival analysis
Online-Zugang:	Volltext
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