Trimethyltin can induce cell death in the entorhinal cortex of rat brain: a histological architecture and neuronal density evaluation of the neuroprotective role of lithium chloride
Trimethyltin as a methylated organotin can induce selective neuronal death in the central nervous system of humans and rodents. On the other hand, lithium has neuroprotective and neurotrophic effects. Therefore, the aim of this study was to evaluate the neuroprotective effects of lithium chloride on...
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| Veröffentlicht in: | Comparative clinical pathology 2015-05, Vol.24 (3), p.605-608 |
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| creator | Homayoon, Mahin Edalatmanesh, Mohammad Amin Moghadas, Marzieh |
| description | Trimethyltin as a methylated organotin can induce selective neuronal death in the central nervous system of humans and rodents. On the other hand, lithium has neuroprotective and neurotrophic effects. Therefore, the aim of this study was to evaluate the neuroprotective effects of lithium chloride on neuronal density in the entorhinal cortex of rat brain after trimethyltin intoxication. Thirty male Sprague–Dawley rats were divided into three equal groups: control, trimethyltin (8 mg/kg, single dose, intraperitoneally), and trimethyltin + lithium chloride (single dose of 8 mg/kg of trimethyltin + 20 mg/kg lithium chloride for 14 consecutive days, intraperitoneally). At the end of the experiment, the entorhinal cortex histopathological examination was performed in all rats of each group. Our results showed that the neural density of the entorhinal cortex in trimethyltin and trimethyltin + lithium chloride groups was significantly decreased in comparison to control group in the levels of
P
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| doi_str_mv | 10.1007/s00580-014-1953-3 |
| format | Article |
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P
< 0.01 and
P
< 0.05, respectively. Also, there was a significant increase in the neural density of the entorhinal cortex in trimethyltin + lithium chloride group against trimethyltin group (
P
< 0.05). These results demonstrated that chronic administration of lithium chloride had significant effects in amelioration of trimethyltin-induced cell death in the entorhinal cortex of rat brain.</description><identifier>ISSN: 1618-5641</identifier><identifier>EISSN: 1618-565X</identifier><identifier>DOI: 10.1007/s00580-014-1953-3</identifier><language>eng</language><publisher>London: Springer London</publisher><subject>Hematology ; Medicine ; Medicine & Public Health ; Oncology ; Original Article ; Pathology</subject><ispartof>Comparative clinical pathology, 2015-05, Vol.24 (3), p.605-608</ispartof><rights>Springer-Verlag London 2014</rights><rights>Springer-Verlag London 2015</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c2643-68f2e360d150b7734730824147055bedde067464508a3edd00919fd662fe96d73</citedby><cites>FETCH-LOGICAL-c2643-68f2e360d150b7734730824147055bedde067464508a3edd00919fd662fe96d73</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s00580-014-1953-3$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s00580-014-1953-3$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,780,784,27924,27925,41488,42557,51319</link.rule.ids></links><search><creatorcontrib>Homayoon, Mahin</creatorcontrib><creatorcontrib>Edalatmanesh, Mohammad Amin</creatorcontrib><creatorcontrib>Moghadas, Marzieh</creatorcontrib><title>Trimethyltin can induce cell death in the entorhinal cortex of rat brain: a histological architecture and neuronal density evaluation of the neuroprotective role of lithium chloride</title><title>Comparative clinical pathology</title><addtitle>Comp Clin Pathol</addtitle><description>Trimethyltin as a methylated organotin can induce selective neuronal death in the central nervous system of humans and rodents. On the other hand, lithium has neuroprotective and neurotrophic effects. Therefore, the aim of this study was to evaluate the neuroprotective effects of lithium chloride on neuronal density in the entorhinal cortex of rat brain after trimethyltin intoxication. Thirty male Sprague–Dawley rats were divided into three equal groups: control, trimethyltin (8 mg/kg, single dose, intraperitoneally), and trimethyltin + lithium chloride (single dose of 8 mg/kg of trimethyltin + 20 mg/kg lithium chloride for 14 consecutive days, intraperitoneally). At the end of the experiment, the entorhinal cortex histopathological examination was performed in all rats of each group. Our results showed that the neural density of the entorhinal cortex in trimethyltin and trimethyltin + lithium chloride groups was significantly decreased in comparison to control group in the levels of
P
< 0.01 and
P
< 0.05, respectively. Also, there was a significant increase in the neural density of the entorhinal cortex in trimethyltin + lithium chloride group against trimethyltin group (
P
< 0.05). These results demonstrated that chronic administration of lithium chloride had significant effects in amelioration of trimethyltin-induced cell death in the entorhinal cortex of rat brain.</description><subject>Hematology</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Oncology</subject><subject>Original Article</subject><subject>Pathology</subject><issn>1618-5641</issn><issn>1618-565X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2015</creationdate><recordtype>article</recordtype><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><recordid>eNp1kc1u1TAQhSMEEqX0AbobiXXoOI7tXHao4qdSpW6KxM7ytSeNK9cutlNxH4z3w-EixKYr_8z5znh8uu6c4XuGqC4KopiwRzb2bCd4z190J0yyqRdSfH_5bz-y192bUu4RmZg4P-l-3Wb_QHU5hOojWBPBR7daAkshgCNTl3YDdSGgWFNefDQBbMqVfkKaIZsK-2x8_AAGFl9qCunO26Yx2S6-kq1rJjDRQaQ1p412FIuvB6AnE1ZTfYqb09bij-Qxpw3zTwQ5BdpqwdfFrw9gl5Cyd_S2ezWbUOjs73raffv86fbya3998-Xq8uN1bwc58l5O80BcomMC90rxUXGchpGNCoXYk3OEUo1yFDgZ3o6IO7abnZTDTDvpFD_t3h1925t-rFSqvk9rbjMUzaSaVHMaRFOxo8rmVEqmWT-2TzX5oBnqLR19TEe3dPSWjuaNGY5Madp4R_k_52eh39TPlc4</recordid><startdate>20150501</startdate><enddate>20150501</enddate><creator>Homayoon, Mahin</creator><creator>Edalatmanesh, Mohammad Amin</creator><creator>Moghadas, Marzieh</creator><general>Springer London</general><general>Springer Nature B.V</general><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7RV</scope><scope>7T5</scope><scope>7X7</scope><scope>7XB</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>H94</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>KB0</scope><scope>LK8</scope><scope>M0S</scope><scope>M7P</scope><scope>NAPCQ</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope></search><sort><creationdate>20150501</creationdate><title>Trimethyltin can induce cell death in the entorhinal cortex of rat brain: a histological architecture and neuronal density evaluation of the neuroprotective role of lithium chloride</title><author>Homayoon, Mahin ; Edalatmanesh, Mohammad Amin ; Moghadas, Marzieh</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c2643-68f2e360d150b7734730824147055bedde067464508a3edd00919fd662fe96d73</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2015</creationdate><topic>Hematology</topic><topic>Medicine</topic><topic>Medicine & Public Health</topic><topic>Oncology</topic><topic>Original Article</topic><topic>Pathology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Homayoon, Mahin</creatorcontrib><creatorcontrib>Edalatmanesh, Mohammad Amin</creatorcontrib><creatorcontrib>Moghadas, Marzieh</creatorcontrib><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Nursing & Allied Health Database</collection><collection>Immunology Abstracts</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Natural Science Collection</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Database (Alumni Edition)</collection><collection>ProQuest Biological Science Collection</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Biological Science Database</collection><collection>Nursing & Allied Health Premium</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><jtitle>Comparative clinical pathology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Homayoon, Mahin</au><au>Edalatmanesh, Mohammad Amin</au><au>Moghadas, Marzieh</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Trimethyltin can induce cell death in the entorhinal cortex of rat brain: a histological architecture and neuronal density evaluation of the neuroprotective role of lithium chloride</atitle><jtitle>Comparative clinical pathology</jtitle><stitle>Comp Clin Pathol</stitle><date>2015-05-01</date><risdate>2015</risdate><volume>24</volume><issue>3</issue><spage>605</spage><epage>608</epage><pages>605-608</pages><issn>1618-5641</issn><eissn>1618-565X</eissn><abstract>Trimethyltin as a methylated organotin can induce selective neuronal death in the central nervous system of humans and rodents. On the other hand, lithium has neuroprotective and neurotrophic effects. Therefore, the aim of this study was to evaluate the neuroprotective effects of lithium chloride on neuronal density in the entorhinal cortex of rat brain after trimethyltin intoxication. Thirty male Sprague–Dawley rats were divided into three equal groups: control, trimethyltin (8 mg/kg, single dose, intraperitoneally), and trimethyltin + lithium chloride (single dose of 8 mg/kg of trimethyltin + 20 mg/kg lithium chloride for 14 consecutive days, intraperitoneally). At the end of the experiment, the entorhinal cortex histopathological examination was performed in all rats of each group. Our results showed that the neural density of the entorhinal cortex in trimethyltin and trimethyltin + lithium chloride groups was significantly decreased in comparison to control group in the levels of
P
< 0.01 and
P
< 0.05, respectively. Also, there was a significant increase in the neural density of the entorhinal cortex in trimethyltin + lithium chloride group against trimethyltin group (
P
< 0.05). These results demonstrated that chronic administration of lithium chloride had significant effects in amelioration of trimethyltin-induced cell death in the entorhinal cortex of rat brain.</abstract><cop>London</cop><pub>Springer London</pub><doi>10.1007/s00580-014-1953-3</doi><tpages>4</tpages></addata></record> |
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| title | Trimethyltin can induce cell death in the entorhinal cortex of rat brain: a histological architecture and neuronal density evaluation of the neuroprotective role of lithium chloride |
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