NOVEL MECHANISM FOR THE SUSTAINED DURABILITY OF PROPROTEIN CONVERTASE SUBTILISIN-KEXIN TYPE 9 MONOCLONAL ANTIBODY LY3015014

LY did not cause an accumulation of intact PCSK9 in serum, which was seen preclinically and in humans treated with other PCSK9 Mabs. Because the LY epitope excludes the furin cleavage site in PCSK9, we asked if furin-mediated degradation proceeds when LY is bound but is blocked by other Mabs.

Bibliographische Detailangaben

Veröffentlicht in:	Journal of the American College of Cardiology 2015-03, Vol.65 (10), p.A1577-A1577
Hauptverfasser:	Eacho, Patrick, Schroeder, Krista, Beyer, Thomas, Hansen, Ryan, Wroblewski, Victor, Han, Bomie, Pickard, Richard, Kowala, Mark
Format:	Artikel
Sprache:	eng
Schlagworte:	Cardiology Cardiovascular Cholesterol Internal Medicine Medical research
Online-Zugang:	Volltext
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