Estrogen receptor a inhibitor activates the unfolded protein response, blocks protein synthesis, and induces tumor regression

Recurrent estrogen receptor α (ERα)-positive breast and ovarian cancers are often therapy resistant. Using screening and functional validation, we identified BHPI, a potent noncompetitive small molecule ERa biomodulator that selectively blocks proliferation of drug-resistant ERα-positive breast and...

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Veröffentlicht in:	Proceedings of the National Academy of Sciences - PNAS 2015-04, Vol.112 (15), p.4737
Hauptverfasser:	Andruska, Neal D, Zheng, Xiaobin, Yang, Xujuan, Mao, Chengjian, Cherian, Mathew M, Mahapatra, Lily, Helferich, William G, Shapiro, David J
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenosine triphosphatase Breast cancer Estrogens Gene expression Ovarian cancer Phosphorylation Protein synthesis
Online-Zugang:	Volltext
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