Genotoxicity potentials of anionic and cationic amino acid-based surfactants
To understand the genotoxic consequences of chemical agents, random amplification of polymorphic DNA (RAPD) as a useful biomarker to be used as an investigation tool for environmental toxicology. In this study, sodium dodecyl sulfate (SDS) was used as a toxic anionic surfactant, and glutamic acid-ba...
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| Veröffentlicht in: | Toxicology and industrial health 2015-04, Vol.31 (4), p.377-385 |
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| description | To understand the genotoxic consequences of chemical agents, random amplification of polymorphic DNA (RAPD) as a useful biomarker to be used as an investigation tool for environmental toxicology. In this study, sodium dodecyl sulfate (SDS) was used as a toxic anionic surfactant, and glutamic acid-based cationic bicatanar surfactant (GS) was used as less toxic cationic amino acid-based surfactant. Experimental results show significant correlations between the RAPD profile changes with root growth, mitotic activity and chromosomal aberration test. The inhibitory rates of root growth at 400 ppm of SDS and GS were 85% and 32%, respectively. Mitotic activity results showed a drastic decrease in SDS exposures, whereas there was no significant decrease in GS treatment. Comparison of the chromosomal aberration test results, rates were indicated at 100, 200 and 400 ppm of SDS and GS; 10, 17, 26 (SDS) and 6, 9, 9 (GS) consequently. Also DNA alterations started at 100 and 200 ppm during SDS and GS exposures, respectively. These preliminary findings encourage the utilization of GS as an environmental friendly surfactant detected by these tools in the investigation of genotoxicity potentials of SDS and GS on maize and the other crops. |
| doi_str_mv | 10.1177/0748233712469657 |
| format | Article |
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In this study, sodium dodecyl sulfate (SDS) was used as a toxic anionic surfactant, and glutamic acid-based cationic bicatanar surfactant (GS) was used as less toxic cationic amino acid-based surfactant. Experimental results show significant correlations between the RAPD profile changes with root growth, mitotic activity and chromosomal aberration test. The inhibitory rates of root growth at 400 ppm of SDS and GS were 85% and 32%, respectively. Mitotic activity results showed a drastic decrease in SDS exposures, whereas there was no significant decrease in GS treatment. Comparison of the chromosomal aberration test results, rates were indicated at 100, 200 and 400 ppm of SDS and GS; 10, 17, 26 (SDS) and 6, 9, 9 (GS) consequently. Also DNA alterations started at 100 and 200 ppm during SDS and GS exposures, respectively. These preliminary findings encourage the utilization of GS as an environmental friendly surfactant detected by these tools in the investigation of genotoxicity potentials of SDS and GS on maize and the other crops.</description><identifier>ISSN: 0748-2337</identifier><identifier>EISSN: 1477-0393</identifier><identifier>DOI: 10.1177/0748233712469657</identifier><identifier>PMID: 23406962</identifier><language>eng</language><publisher>London, England: SAGE Publications</publisher><subject>Amino acids ; Anions - chemistry ; Anions - toxicity ; Biodegradation ; Cations - chemistry ; Cations - toxicity ; Chemical agents ; Chromosome aberrations ; Deoxyribonucleic acid ; DNA ; DNA Damage ; Genetic Markers - genetics ; Genotoxicity ; Glutamic Acid - chemistry ; Mitotic Index ; Mutagens - chemistry ; Mutagens - toxicity ; Plant growth ; Plant Roots - chemistry ; Plant Roots - drug effects ; Plant Roots - metabolism ; Polymerase Chain Reaction ; Random Amplified Polymorphic DNA Technique ; Sodium Dodecyl Sulfate - chemistry ; Sodium Dodecyl Sulfate - toxicity ; Surface-Active Agents - chemistry ; Surface-Active Agents - toxicity ; Surfactants ; Toxicity ; Toxicology ; Zea mays - drug effects ; Zea mays - genetics</subject><ispartof>Toxicology and industrial health, 2015-04, Vol.31 (4), p.377-385</ispartof><rights>The Author(s) 2013</rights><rights>The Author(s) 2013.</rights><rights>SAGE Publications © Apr 2015</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c431t-e2a0be34ca87acbc77c412599be288410d4d6306483b4611ddc15c00f6e46f803</citedby><cites>FETCH-LOGICAL-c431t-e2a0be34ca87acbc77c412599be288410d4d6306483b4611ddc15c00f6e46f803</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://journals.sagepub.com/doi/pdf/10.1177/0748233712469657$$EPDF$$P50$$Gsage$$H</linktopdf><linktohtml>$$Uhttps://journals.sagepub.com/doi/10.1177/0748233712469657$$EHTML$$P50$$Gsage$$H</linktohtml><link.rule.ids>314,776,780,21798,27901,27902,43597,43598</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/23406962$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Kekeç, Güzin</creatorcontrib><creatorcontrib>Cosgun, Sedat</creatorcontrib><title>Genotoxicity potentials of anionic and cationic amino acid-based surfactants</title><title>Toxicology and industrial health</title><addtitle>Toxicol Ind Health</addtitle><description>To understand the genotoxic consequences of chemical agents, random amplification of polymorphic DNA (RAPD) as a useful biomarker to be used as an investigation tool for environmental toxicology. In this study, sodium dodecyl sulfate (SDS) was used as a toxic anionic surfactant, and glutamic acid-based cationic bicatanar surfactant (GS) was used as less toxic cationic amino acid-based surfactant. Experimental results show significant correlations between the RAPD profile changes with root growth, mitotic activity and chromosomal aberration test. The inhibitory rates of root growth at 400 ppm of SDS and GS were 85% and 32%, respectively. Mitotic activity results showed a drastic decrease in SDS exposures, whereas there was no significant decrease in GS treatment. Comparison of the chromosomal aberration test results, rates were indicated at 100, 200 and 400 ppm of SDS and GS; 10, 17, 26 (SDS) and 6, 9, 9 (GS) consequently. Also DNA alterations started at 100 and 200 ppm during SDS and GS exposures, respectively. These preliminary findings encourage the utilization of GS as an environmental friendly surfactant detected by these tools in the investigation of genotoxicity potentials of SDS and GS on maize and the other crops.</description><subject>Amino acids</subject><subject>Anions - chemistry</subject><subject>Anions - toxicity</subject><subject>Biodegradation</subject><subject>Cations - chemistry</subject><subject>Cations - toxicity</subject><subject>Chemical agents</subject><subject>Chromosome aberrations</subject><subject>Deoxyribonucleic acid</subject><subject>DNA</subject><subject>DNA Damage</subject><subject>Genetic Markers - genetics</subject><subject>Genotoxicity</subject><subject>Glutamic Acid - chemistry</subject><subject>Mitotic Index</subject><subject>Mutagens - chemistry</subject><subject>Mutagens - toxicity</subject><subject>Plant growth</subject><subject>Plant Roots - chemistry</subject><subject>Plant Roots - drug effects</subject><subject>Plant Roots - metabolism</subject><subject>Polymerase Chain Reaction</subject><subject>Random Amplified Polymorphic DNA Technique</subject><subject>Sodium Dodecyl Sulfate - chemistry</subject><subject>Sodium Dodecyl Sulfate - toxicity</subject><subject>Surface-Active Agents - chemistry</subject><subject>Surface-Active Agents - toxicity</subject><subject>Surfactants</subject><subject>Toxicity</subject><subject>Toxicology</subject><subject>Zea mays - drug effects</subject><subject>Zea mays - 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Sedat</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Genotoxicity potentials of anionic and cationic amino acid-based surfactants</atitle><jtitle>Toxicology and industrial health</jtitle><addtitle>Toxicol Ind Health</addtitle><date>2015-04-01</date><risdate>2015</risdate><volume>31</volume><issue>4</issue><spage>377</spage><epage>385</epage><pages>377-385</pages><issn>0748-2337</issn><eissn>1477-0393</eissn><abstract>To understand the genotoxic consequences of chemical agents, random amplification of polymorphic DNA (RAPD) as a useful biomarker to be used as an investigation tool for environmental toxicology. In this study, sodium dodecyl sulfate (SDS) was used as a toxic anionic surfactant, and glutamic acid-based cationic bicatanar surfactant (GS) was used as less toxic cationic amino acid-based surfactant. Experimental results show significant correlations between the RAPD profile changes with root growth, mitotic activity and chromosomal aberration test. The inhibitory rates of root growth at 400 ppm of SDS and GS were 85% and 32%, respectively. Mitotic activity results showed a drastic decrease in SDS exposures, whereas there was no significant decrease in GS treatment. Comparison of the chromosomal aberration test results, rates were indicated at 100, 200 and 400 ppm of SDS and GS; 10, 17, 26 (SDS) and 6, 9, 9 (GS) consequently. Also DNA alterations started at 100 and 200 ppm during SDS and GS exposures, respectively. These preliminary findings encourage the utilization of GS as an environmental friendly surfactant detected by these tools in the investigation of genotoxicity potentials of SDS and GS on maize and the other crops.</abstract><cop>London, England</cop><pub>SAGE Publications</pub><pmid>23406962</pmid><doi>10.1177/0748233712469657</doi><tpages>9</tpages></addata></record> |
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| subjects | Amino acids Anions - chemistry Anions - toxicity Biodegradation Cations - chemistry Cations - toxicity Chemical agents Chromosome aberrations Deoxyribonucleic acid DNA DNA Damage Genetic Markers - genetics Genotoxicity Glutamic Acid - chemistry Mitotic Index Mutagens - chemistry Mutagens - toxicity Plant growth Plant Roots - chemistry Plant Roots - drug effects Plant Roots - metabolism Polymerase Chain Reaction Random Amplified Polymorphic DNA Technique Sodium Dodecyl Sulfate - chemistry Sodium Dodecyl Sulfate - toxicity Surface-Active Agents - chemistry Surface-Active Agents - toxicity Surfactants Toxicity Toxicology Zea mays - drug effects Zea mays - genetics |
| title | Genotoxicity potentials of anionic and cationic amino acid-based surfactants |
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