Characterization of anticonvulsant and antiepileptogenic potential of thymol in various experimental models
The present study was to investigate the anticonvulsant and antiepileptogenic potential of thymol. Anticonvulsant activity of thymol (5–100 mg/kg i.p.) was studied using maximal electroshock, pentylenetetrazole (PTZ), strychnine and 4-aminopyridine (4-AP) models. Thymol at the selected dose was also...
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| Veröffentlicht in: | Naunyn-Schmiedeberg's archives of pharmacology 2014, Vol.387 (1), p.59-66 |
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| creator | Sancheti, Jayant Shaikh, Mohd Farooq Chaudhari, Rahul Somani, Gauresh Patil, Sachin Jain, Pankaj Sathaye, Sadhana |
| description | The present study was to investigate the anticonvulsant and antiepileptogenic potential of thymol. Anticonvulsant activity of thymol (5–100 mg/kg i.p.) was studied using maximal electroshock, pentylenetetrazole (PTZ), strychnine and 4-aminopyridine (4-AP) models. Thymol at the selected dose was also studied for its effect on locomotion. Antiepileptogenic property of thymol (5–25 mg/kg) was evaluated using PTZ-induced kindling model along with its effect on malondialdehyde and glutathione levels. Thymol (50 and 100 mg/kg, i.p.) showed anticonvulsant activity against maximal electroshock and pentylenetetrazole (66.66 and 83.33 % protection at 50 and 100 mg/kg, respectively) model but not against strychnine and 4-aminopyridine models. Thymol exhibited decreased locomotor activity in dose-dependent manner at the same dose range. Thymol at the dose of (25 mg/kg, i.p.) significantly decreased the seizure score, increased glutathione levels and decreased malondialdehyde levels in pentylenetetrazole-induced kindling model. Thymol exhibited significant anticonvulsant and antiepileptogenic property. |
| doi_str_mv | 10.1007/s00210-013-0917-5 |
| format | Article |
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Anticonvulsant activity of thymol (5–100 mg/kg i.p.) was studied using maximal electroshock, pentylenetetrazole (PTZ), strychnine and 4-aminopyridine (4-AP) models. Thymol at the selected dose was also studied for its effect on locomotion. Antiepileptogenic property of thymol (5–25 mg/kg) was evaluated using PTZ-induced kindling model along with its effect on malondialdehyde and glutathione levels. Thymol (50 and 100 mg/kg, i.p.) showed anticonvulsant activity against maximal electroshock and pentylenetetrazole (66.66 and 83.33 % protection at 50 and 100 mg/kg, respectively) model but not against strychnine and 4-aminopyridine models. Thymol exhibited decreased locomotor activity in dose-dependent manner at the same dose range. Thymol at the dose of (25 mg/kg, i.p.) significantly decreased the seizure score, increased glutathione levels and decreased malondialdehyde levels in pentylenetetrazole-induced kindling model. 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Anticonvulsant activity of thymol (5–100 mg/kg i.p.) was studied using maximal electroshock, pentylenetetrazole (PTZ), strychnine and 4-aminopyridine (4-AP) models. Thymol at the selected dose was also studied for its effect on locomotion. Antiepileptogenic property of thymol (5–25 mg/kg) was evaluated using PTZ-induced kindling model along with its effect on malondialdehyde and glutathione levels. Thymol (50 and 100 mg/kg, i.p.) showed anticonvulsant activity against maximal electroshock and pentylenetetrazole (66.66 and 83.33 % protection at 50 and 100 mg/kg, respectively) model but not against strychnine and 4-aminopyridine models. Thymol exhibited decreased locomotor activity in dose-dependent manner at the same dose range. Thymol at the dose of (25 mg/kg, i.p.) significantly decreased the seizure score, increased glutathione levels and decreased malondialdehyde levels in pentylenetetrazole-induced kindling model. Thymol exhibited significant anticonvulsant and antiepileptogenic property.</description><subject>Animals</subject><subject>Anticonvulsants - therapeutic use</subject><subject>Biomedical and Life Sciences</subject><subject>Biomedicine</subject><subject>Disease Models, Animal</subject><subject>Dose-Response Relationship, Drug</subject><subject>Male</subject><subject>Mice</subject><subject>Neurosciences</subject><subject>Original Article</subject><subject>Pentylenetetrazole - toxicity</subject><subject>Pharmacology/Toxicology</subject><subject>Rats</subject><subject>Rats, Wistar</subject><subject>Seizures - chemically induced</subject><subject>Seizures - drug therapy</subject><subject>Seizures - physiopathology</subject><subject>Thymol - therapeutic use</subject><issn>0028-1298</issn><issn>1432-1912</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2014</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>BENPR</sourceid><recordid>eNp1kEtPwzAQhC0EoqXwA7igSJwDa-dh54gqXlIlLnC2nHjdpiRxsBNE-fW4tCAunGzvfjNjDSHnFK4oAL_2AIxCDDSJoaA8zg7IlKYJi2lB2SGZhrWIKSvEhJx4vwaAnGbZMZmwFPIMBJ-S1_lKOVUN6OpPNdS2i6yJVDfUle3ex8aHa3jq7xH2dYP9YJfY1VXU2wHDUDVbxbDatLaJ6i56V662o4_wow-ebUAC0VqNjT8lR0Y1Hs_254y83N0-zx_ixdP94_xmEVcJZ0PMExCVNgUtTZmCyXNhcp4WShiViwILjbpQiFhqrFKquWAMdFlhZgQzirFkRi53vr2zbyP6Qa7t6LoQKWnOIWEhgAeK7qjKWe8dGtmH_yq3kRTktl65q1eGeuW2XpkFzcXeeSxb1L-Knz4DwHaAD6tuie5P9L-uX12siNk</recordid><startdate>2014</startdate><enddate>2014</enddate><creator>Sancheti, Jayant</creator><creator>Shaikh, Mohd Farooq</creator><creator>Chaudhari, Rahul</creator><creator>Somani, Gauresh</creator><creator>Patil, Sachin</creator><creator>Jain, Pankaj</creator><creator>Sathaye, Sadhana</creator><general>Springer Berlin Heidelberg</general><general>Springer Nature B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7QP</scope><scope>7TK</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>K9.</scope><scope>M0S</scope><scope>M1P</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope></search><sort><creationdate>2014</creationdate><title>Characterization of anticonvulsant and antiepileptogenic potential of thymol in various experimental models</title><author>Sancheti, Jayant ; Shaikh, Mohd Farooq ; Chaudhari, Rahul ; Somani, Gauresh ; Patil, Sachin ; Jain, Pankaj ; Sathaye, Sadhana</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c372t-7308cdf91bfb40f668f6749a8fa689e9ded9aeeebdec41d78220dbce5f82fa223</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2014</creationdate><topic>Animals</topic><topic>Anticonvulsants - therapeutic use</topic><topic>Biomedical and Life Sciences</topic><topic>Biomedicine</topic><topic>Disease Models, Animal</topic><topic>Dose-Response Relationship, Drug</topic><topic>Male</topic><topic>Mice</topic><topic>Neurosciences</topic><topic>Original Article</topic><topic>Pentylenetetrazole - toxicity</topic><topic>Pharmacology/Toxicology</topic><topic>Rats</topic><topic>Rats, Wistar</topic><topic>Seizures - chemically induced</topic><topic>Seizures - drug therapy</topic><topic>Seizures - physiopathology</topic><topic>Thymol - therapeutic use</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Sancheti, Jayant</creatorcontrib><creatorcontrib>Shaikh, Mohd Farooq</creatorcontrib><creatorcontrib>Chaudhari, Rahul</creatorcontrib><creatorcontrib>Somani, Gauresh</creatorcontrib><creatorcontrib>Patil, Sachin</creatorcontrib><creatorcontrib>Jain, Pankaj</creatorcontrib><creatorcontrib>Sathaye, Sadhana</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Calcium & Calcified Tissue Abstracts</collection><collection>Neurosciences Abstracts</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><jtitle>Naunyn-Schmiedeberg's archives of pharmacology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Sancheti, Jayant</au><au>Shaikh, Mohd Farooq</au><au>Chaudhari, Rahul</au><au>Somani, Gauresh</au><au>Patil, Sachin</au><au>Jain, Pankaj</au><au>Sathaye, Sadhana</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Characterization of anticonvulsant and antiepileptogenic potential of thymol in various experimental models</atitle><jtitle>Naunyn-Schmiedeberg's archives of pharmacology</jtitle><stitle>Naunyn-Schmiedeberg's Arch Pharmacol</stitle><addtitle>Naunyn Schmiedebergs Arch Pharmacol</addtitle><date>2014</date><risdate>2014</risdate><volume>387</volume><issue>1</issue><spage>59</spage><epage>66</epage><pages>59-66</pages><issn>0028-1298</issn><eissn>1432-1912</eissn><abstract>The present study was to investigate the anticonvulsant and antiepileptogenic potential of thymol. Anticonvulsant activity of thymol (5–100 mg/kg i.p.) was studied using maximal electroshock, pentylenetetrazole (PTZ), strychnine and 4-aminopyridine (4-AP) models. Thymol at the selected dose was also studied for its effect on locomotion. Antiepileptogenic property of thymol (5–25 mg/kg) was evaluated using PTZ-induced kindling model along with its effect on malondialdehyde and glutathione levels. Thymol (50 and 100 mg/kg, i.p.) showed anticonvulsant activity against maximal electroshock and pentylenetetrazole (66.66 and 83.33 % protection at 50 and 100 mg/kg, respectively) model but not against strychnine and 4-aminopyridine models. Thymol exhibited decreased locomotor activity in dose-dependent manner at the same dose range. Thymol at the dose of (25 mg/kg, i.p.) significantly decreased the seizure score, increased glutathione levels and decreased malondialdehyde levels in pentylenetetrazole-induced kindling model. Thymol exhibited significant anticonvulsant and antiepileptogenic property.</abstract><cop>Berlin/Heidelberg</cop><pub>Springer Berlin Heidelberg</pub><pmid>24065087</pmid><doi>10.1007/s00210-013-0917-5</doi><tpages>8</tpages></addata></record> |
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| subjects | Animals Anticonvulsants - therapeutic use Biomedical and Life Sciences Biomedicine Disease Models, Animal Dose-Response Relationship, Drug Male Mice Neurosciences Original Article Pentylenetetrazole - toxicity Pharmacology/Toxicology Rats Rats, Wistar Seizures - chemically induced Seizures - drug therapy Seizures - physiopathology Thymol - therapeutic use |
| title | Characterization of anticonvulsant and antiepileptogenic potential of thymol in various experimental models |
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