Synthetically modified bioisosteres of salicyl alcohol and their gastroulcerogenic assessment versus aspirin: biochemical and histological correlates

The present study was conducted to synthesize nitrogen containing derivatives of salicyl alcohol and to investigate in vivo their ulcerogenic potential in comparison with aspirin in rats. The compounds [4-(2-hydroxybenzyl) morpholin-4-iumchloride (I)] and [1,4-bis(2-hydroxybenzyl) piperazine-1,4-dii...

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Veröffentlicht in:	Naunyn-Schmiedeberg's archives of pharmacology 2014-03, Vol.387 (3), p.281-290
Hauptverfasser:	Ali, Gowhar, Subhan, Fazal, Islam, Nazar Ul, Ullah, Nasir, Sewell, Robert D. E., Shahid, Muhammad, Khan, Ikhtiar
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Anti-Inflammatory Agents, Non-Steroidal - chemical synthesis Anti-Inflammatory Agents, Non-Steroidal - chemistry Anti-Inflammatory Agents, Non-Steroidal - toxicity Aspirin - toxicity Benzyl Alcohols - chemical synthesis Benzyl Alcohols - chemistry Benzyl Alcohols - toxicity Biomedical and Life Sciences Biomedicine Cyclooxygenase 1 - metabolism Cyclooxygenase 2 - metabolism Dose-Response Relationship, Drug Female Gastric Juice - metabolism Gastric Mucosa - drug effects Gastric Mucosa - pathology Hydrogen-Ion Concentration Male Molecular Docking Simulation Molecular Dynamics Simulation Neurosciences Original Article Pharmacology/Toxicology Rats Rats, Sprague-Dawley Stomach Ulcer - chemically induced Stomach Ulcer - pathology
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