[gamma]134.5-deleted HSV-1-expressing human cytomegalovirus IRS1 gene kills human glioblastoma cells as efficiently as wild-type HSV-1 in normoxia or hypoxia

Pathophysiological hypoxia, which fosters the glioma stem-like cell (GSC) phenotype, is present in high-grade gliomas and has been linked to tumor development, invasiveness and resistance to chemotherapy and radiation. Oncolytic virotherapy with engineered herpes simplex virus-1 (HSV-1) is a promisi...

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Veröffentlicht in:	Gene therapy 2015-04, Vol.22 (4), p.348
Hauptverfasser:	Friedman, G K, Nan, L, Haas, M C, Kelly, V M, Moore, B P, Langford, C P, Xu, H, Han, X, Beierle, E A, Markert, J M, Cassady, K A, Gillespie, G Y
Format:	Artikel
Sprache:	eng
Schlagworte:	Cytomegalovirus Cytotoxicity Gene therapy Genotype & phenotype Herpes viruses Hypoxia Proteins
Online-Zugang:	Volltext
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