Targeting apoptosis pathways by Celecoxib in cancer

Abstract Celecoxib is a paradigmatic selective inhibitor of cyclooxygenase-2 (COX-2). This anti-inflammatory drug has potent anti-tumor activity in a wide variety of human epithelial tumor types, such as colorectal, breast, non-small cell lung, and prostate cancers. Up to now, the drug found applica...

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Veröffentlicht in:	Cancer letters 2013-05, Vol.332 (2), p.313-324
1. Verfasser:	Jendrossek, Verena
Format:	Artikel
Sprache:	eng
Schlagworte:	animal ovaries Animals anti-inflammatory agents Anti-Inflammatory Agents - therapeutic use anticarcinogenic activity Antineoplastic Agents - therapeutic use Apoptosis Bcl-2 cardiac arrest Celecoxib Cell cycle chemotherapy COX-2 Cyclooxygenase 2 - metabolism Drug Screening Assays, Antitumor - methods Endoplasmic Reticulum - metabolism Hematology, Oncology and Palliative Medicine Humans Inhibitor of Apoptosis Proteins - metabolism Kinases Laboratories lung neoplasms Mcl-1 Myeloid Cell Leukemia Sequence 1 Protein Neoplasms - drug therapy Neoplasms - pathology patients prostaglandin synthase proteins Proto-Oncogene Proteins c-bcl-2 - metabolism Pyrazoles - therapeutic use radiotherapy risk stroke stromal cells Sulfonamides - therapeutic use toxicity
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