Investigation of Antiulcer and Antioxidant Activity of Moclobemide in Rats/Moklobemidin Sicanlarda Antiulser ve Antioksidan Aktivitesinin Arastirilmasi

Objective: Even though there are many drugs for the treatment of gastric ulcers, these drugs sometimes cannot succeed. Since the 1950s, antidepressant drugs have been used for several non-psychiatric indications. Many antidepressant drugs have been shown experimentally to produce antiulcer activity in various ulcer models. Moclobemide is an antidepressant drug which inhibits monoamine oxidase-A (MAO) enzyme selectively. When it is compared to the classic antidepressants drugs, moclobemide is the first choice in depression treatment because of its effectiveness and less side effects. This study aimed to investigate the antiulcer effects of moclobemide and to determine its relationship with antioxidant mechanisms in rat gastric tissue. Materials and Methods: The antiulcer activities of 10, 20, 40, 80, 150 mg/kg moclobemide and 20 mg/kg famotidine have been investigated on indomethacin-induced ulcers in rats, and the results have been compared with that of the control group. Results: Moclobemide decreased the indomethacin-induced ulcers significantly at all doses used. While used doses of moclobemide increased the glutathione (GSH), nitric oxide (NO) level and superoxide dismutase (SOD) activity, it decreased the malondialdehyde (MDA) level and myeloperoxidase (MPO) activity in stomach tissue when compared to the control group. Conclusion: It is determined that an antidepressant drug, moclobemide is a potent anti-ulcer agent. Inhibition of toxic oxidant radicals and activation of antioxidant mechanisms play a role in its antiulcer effect mechanisms. Keywords: Moclobemide, ulcer, antioxidants, indomethacin, rat Amac: Peptik ulser tedavisinde kullanilan cok sayida klasik antiulser ilac gruplari bulunsa da, bu ilaclar ile ulserin kalici tedavisi saglanamamaktadir. 1950'den beri antidepresan ilaclar non - psikiyatrik bazi hastaliklarin tedavisinde kullanilmaktadirlar. Bircok antidepresan ilacin antiulser aktiviteye sahip olduklari deneysel ve klinik calismalarla da gosterilmistir. Moklobemid, monoaminooksidaz - A (MAO - A) enziminin selektif inhibitoru antidepresan bir ilactir. Klasik MAO inhibitorleri ile karsilastirildiginda, etkinliginin fazla olmasi ve yan etkilerinin az olmasi nedeni ile depresyon tedavisinde tercih edilmektedir. Bu calismada sican mide dokusunda moklobemidin antiulser etkilerinin arastirilmasi ve oksidan mekanizmalarla iliskisinin belirlenmesi amaclanmistir. Gerec ve Yontem: 10, 20, 40, 80 ve 150 mg/kg dozlarinda kullanilan moklobemid ve 20