Combined suppression of the intrarenal and circulating vasoconstrictor renin-ACE-ANG II axis and augmentation of the vasodilator ACE2-ANG 1-7-Mas axis attenuates the systemic hypertension in Ren-2 transgenic rats exposed to chronic hypoxia

The aim of the present study was to test the hypothesis that chronic hypoxia would aggravate hypertension in Ren-2 transgenic rats (TGR), a well-defined monogenetic model of hypertension with increased activity of endogenous renin-angiotensin system (RAS). Systolic blood pressure (SBP) in conscious...

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Veröffentlicht in:	Physiological research 2015-01, Vol.64 (1), p.11-24
Hauptverfasser:	Červenka, L, Bíbová, J, Husková, Z, Vaňourková, Z, Kramer, H J, Herget, J, Jíchová, Š, Sadowski, J, Hampl, V
Format:	Artikel
Sprache:	eng
Schlagworte:	Age Age Factors Angiotensin I - blood Angiotensin II - blood Animals Blood Pressure Disease Models, Animal Genomes Hypertension Hypertension - blood Hypertension - genetics Hypertension - physiopathology Hypertension - prevention & control Hypoxia Hypoxia - complications Hypoxia - enzymology Hypoxia - physiopathology Kidney - enzymology Medicine Peptide Fragments - blood Peptidyl-Dipeptidase A - blood Proto-Oncogene Proteins - blood Rats, Sprague-Dawley Rats, Transgenic Receptors, G-Protein-Coupled - blood Renin - blood Renin - genetics Renin-Angiotensin System Rodents Signal Transduction Studies Vasoconstriction Vasodilation
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