Photo-Responsive and NGR-Mediated Multifunctional Nanostructured Lipid Carrier for Tumor-Specific Therapy

A novel nanostructured lipid carrier (NLC) modified with photon-sensitive cell penetrating peptides (psCPP) and Asn-Gly-Arg (NGR) was designed to enhance paclitaxel (PTX)-targeted delivery and antitumor effect. The NGR moiety selectively binds to CD13-positive tumors. On other hand, the psCPP moiety...

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Veröffentlicht in:	Journal of pharmaceutical sciences 2015-04, Vol.104 (4), p.1328-1339
Hauptverfasser:	Yang, Yanfang, Xie, Xiangyang, Yang, Yang, Zhang, Hui, Mei, Xingguo
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antineoplastic Agents, Phytogenic - administration & dosage Antineoplastic Agents, Phytogenic - chemistry Antineoplastic Agents, Phytogenic - metabolism Antineoplastic Agents, Phytogenic - pharmacokinetics cancer chemotherapy Cell Survival - drug effects Cell-Penetrating Peptides - chemistry Cell-Penetrating Peptides - radiation effects Chemistry, Pharmaceutical Colorectal Neoplasms - blood Colorectal Neoplasms - drug therapy Colorectal Neoplasms - pathology Dose-Response Relationship, Drug Drug Carriers Drug Stability Female Half-Life Humans Infrared Rays Injections, Intravenous light activation lipids Lipids - chemistry Male MCF-7 Cells Mice, Inbred BALB C Mice, Nude Nanoparticles Nanotechnology NGR-targeted Oligopeptides - chemistry Oligopeptides - radiation effects Paclitaxel - administration & dosage Paclitaxel - chemistry Paclitaxel - metabolism Paclitaxel - pharmacokinetics Particle Size peptides Photons Rats, Sprague-Dawley Solubility targeted drug delivery Technology, Pharmaceutical - methods Xenograft Model Antitumor Assays
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