Attention deficit/hyperactivity disorder (ADHD) is associated with altered heart rate asymmetry
Attention deficit/hyperactivity disorder (ADHD) is associated with complex neurocardiac integrity. We aimed to study heart rate time asymmetry as a nonlinear qualitative feature of heart rate variability indicating complexity of cardiac autonomic control at rest and in response to physiological stre...
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| Veröffentlicht in: | Physiological research 2014-01, Vol.63 Suppl 4, p.S509-S519 |
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| container_title | Physiological research |
| container_volume | 63 Suppl 4 |
| creator | Tonhajzerová, I Ondrejka, I Farský, I Višňovcová, Z Mešťaník, M Javorka, M Jurko, Jr, A Čalkovská, A |
| description | Attention deficit/hyperactivity disorder (ADHD) is associated with complex neurocardiac integrity. We aimed to study heart rate time asymmetry as a nonlinear qualitative feature of heart rate variability indicating complexity of cardiac autonomic control at rest and in response to physiological stress (orthostasis) in children suffering from ADHD. Twenty boys with ADHD and 20 healthy age-matched boys at the age of 8 to 12 years were examined. The continuous ECG was recorded in a supine position and during postural change from lying to standing (orthostasis). Time irreversibility indices - Porta's (P%), Guzik's (G%) and Ehlers' (E) - were evaluated. Our analysis showed significantly reduced heart rate asymmetry indices at rest (P%: 49.8 % vs. 52.2 %; G%: 50.2 % vs. 53.2 %; p |
| doi_str_mv | 10.33549/physiolres.932919 |
| format | Article |
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We aimed to study heart rate time asymmetry as a nonlinear qualitative feature of heart rate variability indicating complexity of cardiac autonomic control at rest and in response to physiological stress (orthostasis) in children suffering from ADHD. Twenty boys with ADHD and 20 healthy age-matched boys at the age of 8 to 12 years were examined. The continuous ECG was recorded in a supine position and during postural change from lying to standing (orthostasis). Time irreversibility indices - Porta's (P%), Guzik's (G%) and Ehlers' (E) - were evaluated. Our analysis showed significantly reduced heart rate asymmetry indices at rest (P%: 49.8 % vs. 52.2 %; G%: 50.2 % vs. 53.2 %; p<0.02), and in response to orthostatic load (P%: 52.4 % vs. 54.5 %, G%: 52.3 % vs. 54.5 %; p<0.05) associated with tachycardia in ADHD children compared to controls. Concluding, our study firstly revealed the altered heart rate asymmetry pattern in children suffering from ADHD at rest as well as in response to posture change from lying to standing (orthostasis). These findings might reflect an abnormal complex cardiac regulatory system as a potential mechanism leading to later cardiac adverse outcomes in ADHD.</description><identifier>ISSN: 0862-8408</identifier><identifier>EISSN: 1802-9973</identifier><identifier>DOI: 10.33549/physiolres.932919</identifier><identifier>PMID: 25669682</identifier><language>eng</language><publisher>Czech Republic: Institute of Physiology</publisher><subject>Age ; Asymmetry ; Attention Deficit Disorder with Hyperactivity - physiopathology ; Attention Deficit Hyperactivity Disorder ; Behavior ; Brain research ; Cardiac arrhythmia ; Case-Control Studies ; Child ; Comorbidity ; Heart ; Heart - physiopathology ; Heart Rate ; Humans ; Hyperactivity ; Mental disorders ; Nervous system ; Posture ; Studies ; Time series</subject><ispartof>Physiological research, 2014-01, Vol.63 Suppl 4, p.S509-S519</ispartof><rights>Copyright Institute of Physiology 2014</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c342t-ad3ea62d62d11989313f6bf98bd1253706d51910909a96ee9d17327505e865163</citedby><cites>FETCH-LOGICAL-c342t-ad3ea62d62d11989313f6bf98bd1253706d51910909a96ee9d17327505e865163</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,864,27924,27925</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/25669682$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Tonhajzerová, I</creatorcontrib><creatorcontrib>Ondrejka, I</creatorcontrib><creatorcontrib>Farský, I</creatorcontrib><creatorcontrib>Višňovcová, Z</creatorcontrib><creatorcontrib>Mešťaník, M</creatorcontrib><creatorcontrib>Javorka, M</creatorcontrib><creatorcontrib>Jurko, Jr, A</creatorcontrib><creatorcontrib>Čalkovská, A</creatorcontrib><title>Attention deficit/hyperactivity disorder (ADHD) is associated with altered heart rate asymmetry</title><title>Physiological research</title><addtitle>Physiol Res</addtitle><description>Attention deficit/hyperactivity disorder (ADHD) is associated with complex neurocardiac integrity. We aimed to study heart rate time asymmetry as a nonlinear qualitative feature of heart rate variability indicating complexity of cardiac autonomic control at rest and in response to physiological stress (orthostasis) in children suffering from ADHD. Twenty boys with ADHD and 20 healthy age-matched boys at the age of 8 to 12 years were examined. The continuous ECG was recorded in a supine position and during postural change from lying to standing (orthostasis). Time irreversibility indices - Porta's (P%), Guzik's (G%) and Ehlers' (E) - were evaluated. Our analysis showed significantly reduced heart rate asymmetry indices at rest (P%: 49.8 % vs. 52.2 %; G%: 50.2 % vs. 53.2 %; p<0.02), and in response to orthostatic load (P%: 52.4 % vs. 54.5 %, G%: 52.3 % vs. 54.5 %; p<0.05) associated with tachycardia in ADHD children compared to controls. Concluding, our study firstly revealed the altered heart rate asymmetry pattern in children suffering from ADHD at rest as well as in response to posture change from lying to standing (orthostasis). These findings might reflect an abnormal complex cardiac regulatory system as a potential mechanism leading to later cardiac adverse outcomes in ADHD.</description><subject>Age</subject><subject>Asymmetry</subject><subject>Attention Deficit Disorder with Hyperactivity - physiopathology</subject><subject>Attention Deficit Hyperactivity Disorder</subject><subject>Behavior</subject><subject>Brain research</subject><subject>Cardiac arrhythmia</subject><subject>Case-Control Studies</subject><subject>Child</subject><subject>Comorbidity</subject><subject>Heart</subject><subject>Heart - physiopathology</subject><subject>Heart Rate</subject><subject>Humans</subject><subject>Hyperactivity</subject><subject>Mental disorders</subject><subject>Nervous system</subject><subject>Posture</subject><subject>Studies</subject><subject>Time series</subject><issn>0862-8408</issn><issn>1802-9973</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2014</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>8G5</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><sourceid>GUQSH</sourceid><sourceid>M2O</sourceid><recordid>eNpFkE1LAzEQhoMotlb_gAcJeNHDtvlossmxtGqFghc9h3Qzy6Z0u2uSWvbfu9iqMDAM837Ag9AtJWPOxVRP2qqLvtkGiGPNmab6DA2pIizTOufnaEiUZJmaEjVAVzFuCGE5yfklGjAhpZaKDZGZpQS75JsddlD6wqdJ1bUQbJH8l08ddj42wUHAD7PFcvGIfcQ2xqbwNoHDB58qbLcJQn9UYEPCoX_0kq6uIYXuGl2Udhvh5rRH6OP56X2-zFZvL6_z2Sor-JSlzDoOVjLXD6VaaU55KdelVmtHmeA5kU5QTYkm2moJoB3NOcsFEaCkoJKP0P0xtw3N5x5iMptmH3Z9paFS0pwJylmvYkdVEZoYA5SmDb62oTOUmB-m5p-pOTLtTXen6P26Bvdn-YXIvwF1Q3UZ</recordid><startdate>20140101</startdate><enddate>20140101</enddate><creator>Tonhajzerová, I</creator><creator>Ondrejka, I</creator><creator>Farský, I</creator><creator>Višňovcová, Z</creator><creator>Mešťaník, M</creator><creator>Javorka, M</creator><creator>Jurko, Jr, A</creator><creator>Čalkovská, A</creator><general>Institute of Physiology</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>4T-</scope><scope>4U-</scope><scope>7RV</scope><scope>7X7</scope><scope>7XB</scope><scope>88A</scope><scope>88E</scope><scope>8AO</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>8G5</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>BYOGL</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>GUQSH</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>KB0</scope><scope>LK8</scope><scope>M0S</scope><scope>M1P</scope><scope>M2O</scope><scope>M7P</scope><scope>MBDVC</scope><scope>NAPCQ</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>Q9U</scope></search><sort><creationdate>20140101</creationdate><title>Attention deficit/hyperactivity disorder (ADHD) is associated with altered heart rate asymmetry</title><author>Tonhajzerová, I ; 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We aimed to study heart rate time asymmetry as a nonlinear qualitative feature of heart rate variability indicating complexity of cardiac autonomic control at rest and in response to physiological stress (orthostasis) in children suffering from ADHD. Twenty boys with ADHD and 20 healthy age-matched boys at the age of 8 to 12 years were examined. The continuous ECG was recorded in a supine position and during postural change from lying to standing (orthostasis). Time irreversibility indices - Porta's (P%), Guzik's (G%) and Ehlers' (E) - were evaluated. Our analysis showed significantly reduced heart rate asymmetry indices at rest (P%: 49.8 % vs. 52.2 %; G%: 50.2 % vs. 53.2 %; p<0.02), and in response to orthostatic load (P%: 52.4 % vs. 54.5 %, G%: 52.3 % vs. 54.5 %; p<0.05) associated with tachycardia in ADHD children compared to controls. Concluding, our study firstly revealed the altered heart rate asymmetry pattern in children suffering from ADHD at rest as well as in response to posture change from lying to standing (orthostasis). These findings might reflect an abnormal complex cardiac regulatory system as a potential mechanism leading to later cardiac adverse outcomes in ADHD.</abstract><cop>Czech Republic</cop><pub>Institute of Physiology</pub><pmid>25669682</pmid><doi>10.33549/physiolres.932919</doi><oa>free_for_read</oa></addata></record> |
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| ispartof | Physiological research, 2014-01, Vol.63 Suppl 4, p.S509-S519 |
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| source | MEDLINE; DOAJ Directory of Open Access Journals; EZB-FREE-00999 freely available EZB journals |
| subjects | Age Asymmetry Attention Deficit Disorder with Hyperactivity - physiopathology Attention Deficit Hyperactivity Disorder Behavior Brain research Cardiac arrhythmia Case-Control Studies Child Comorbidity Heart Heart - physiopathology Heart Rate Humans Hyperactivity Mental disorders Nervous system Posture Studies Time series |
| title | Attention deficit/hyperactivity disorder (ADHD) is associated with altered heart rate asymmetry |
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