Dual add-on therapy in type 2 diabetes poorly controlled with metformin monotherapy: a randomized double-blind trial of saxagliptin plus dapagliflozin addition versus single addition of saxagliptin or dapagliflozin to metformin

This study compared the efficacy and safety of dual add-on of saxagliptin plus dapagliflozin versus saxagliptin and dapagliflozin added on alone in patients with type 2 diabetes poorly controlled with metformin. This was a double-blind trial in adults with HbA1c ≥8.0% and ≤12.0% (64-108 mmol/mol), r...

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Veröffentlicht in:	Diabetes care 2015-03, Vol.38 (3), p.376-383
Hauptverfasser:	Rosenstock, Julio, Hansen, Lars, Zee, Pamela, Li, Yan, Cook, William, Hirshberg, Boaz, Iqbal, Nayyar
Format:	Artikel
Sprache:	eng
Schlagworte:	Adamantane - administration & dosage Adamantane - adverse effects Adamantane - analogs & derivatives Adult Aged Benzhydryl Compounds - administration & dosage Benzhydryl Compounds - adverse effects Blood Glucose - drug effects Blood Glucose - metabolism Clinical trials Diabetes Diabetes Mellitus, Type 2 - blood Diabetes Mellitus, Type 2 - drug therapy Dipeptides - administration & dosage Dipeptides - adverse effects Double-Blind Method Drug therapy Drug Therapy, Combination Female Glucosides - administration & dosage Glucosides - adverse effects Humans Hypoglycemia - chemically induced Male Metformin - administration & dosage Metformin - adverse effects Middle Aged Treatment Outcome Urinary Tract Infections - chemically induced
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