Association of mycobacterium tuberculosis in the causation of Eales’ disease: An institutional experience
Background: Eales’ disease is an idiopathic retinal vasculitis characterized by retinal inflammation, ischemia, and neo-vascularisation. It frequently causes massive vitreous haemorrhage and retinal detachment leading to blindness. Although the exact etiology is unknown, this condition is considered...
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| Veröffentlicht in: | Indian journal of medical microbiology 2015-02, Vol.33, p.S43-S45 |
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| description | Background: Eales’ disease is an idiopathic retinal vasculitis characterized by retinal inflammation, ischemia, and neo-vascularisation. It frequently causes massive vitreous haemorrhage and retinal detachment leading to blindness. Although the exact etiology is unknown, this condition is considered to be a consequence of hypersensitivity reaction to tubercular protein due to previous Mycobacterium tuberculosis (M. tuberculosis) infection. This study is aimed at the detection of association of M. tuberculosis in patients with Eales’ disease. Materials and Methods: A prospective case-control study was undertaken in 65 clinically diagnosed cases of Eales’ disease. Patients with proliferative diabetic retinopathy, neo-vascular proliferation, macular oedema, premacular fibrosis and tractional retinal detachment were taken as controls. M. tuberculosis DNA was detected (MPT64 gene by polymerase chain reaction, PCR) in patients with Eales’ disease. Clinical symptoms along with tuberculin skin test (TST) and erythrocyte sedimentation rate (ESR) were used as gold standard for comparing results of PCR. Result: PCR positivity was found in 12 (38.7%) patients with Eales’ disease. The PCR positivity was significantly associated with the patients with high TST reading and high ESR values. Conclusion: Patients with a high TST reading and ESR value and a positive PCR in vitreous samples have a high likelihood of having M. tuberculosis as an etiology. |
| doi_str_mv | 10.4103/0255-0857.148829 |
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It frequently causes massive vitreous haemorrhage and retinal detachment leading to blindness. Although the exact etiology is unknown, this condition is considered to be a consequence of hypersensitivity reaction to tubercular protein due to previous Mycobacterium tuberculosis (M. tuberculosis) infection. This study is aimed at the detection of association of M. tuberculosis in patients with Eales’ disease. Materials and Methods: A prospective case-control study was undertaken in 65 clinically diagnosed cases of Eales’ disease. Patients with proliferative diabetic retinopathy, neo-vascular proliferation, macular oedema, premacular fibrosis and tractional retinal detachment were taken as controls. M. tuberculosis DNA was detected (MPT64 gene by polymerase chain reaction, PCR) in patients with Eales’ disease. Clinical symptoms along with tuberculin skin test (TST) and erythrocyte sedimentation rate (ESR) were used as gold standard for comparing results of PCR. Result: PCR positivity was found in 12 (38.7%) patients with Eales’ disease. The PCR positivity was significantly associated with the patients with high TST reading and high ESR values. Conclusion: Patients with a high TST reading and ESR value and a positive PCR in vitreous samples have a high likelihood of having M. tuberculosis as an etiology.</description><identifier>ISSN: 0255-0857</identifier><identifier>EISSN: 1998-3646</identifier><identifier>DOI: 10.4103/0255-0857.148829</identifier><identifier>PMID: 25657155</identifier><language>eng</language><publisher>India: Elsevier B.V</publisher><subject>Adult ; Blood Sedimentation ; Case-Control Studies ; Deoxyribonucleic acid ; Diabetic retinopathy ; Disease ; DNA ; Eales’ disease ; Humans ; Hypotheses ; Immunology ; Infections ; Laboratories ; Molecular weight ; Mycobacterium tuberculosis ; Mycobacterium tuberculosis - genetics ; Neovascularization, Pathologic - diagnosis ; Neovascularization, Pathologic - microbiology ; Pathogenesis ; Polymerase Chain Reaction ; retinal detachment ; Retinal Vasculitis - diagnosis ; Retinal Vasculitis - microbiology ; Risk Factors ; Tuberculosis ; Tuberculosis - diagnosis ; Tuberculosis - microbiology ; vitreous haemorrhage ; Young Adult</subject><ispartof>Indian journal of medical microbiology, 2015-02, Vol.33, p.S43-S45</ispartof><rights>2015 Indian Journal of Medical Microbiology</rights><rights>Copyright Medknow Publications & Media Pvt Ltd 2015</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c420t-2322f6391ddc82035e64ac010d191591dbf8ac2084933826d94c60be8ae839b33</citedby><cites>FETCH-LOGICAL-c420t-2322f6391ddc82035e64ac010d191591dbf8ac2084933826d94c60be8ae839b33</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.proquest.com/docview/1656397811?pq-origsite=primo$$EHTML$$P50$$Gproquest$$Hfree_for_read</linktohtml><link.rule.ids>314,780,784,27924,27925,64385,64389,72469</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/25657155$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Rajpal</creatorcontrib><creatorcontrib>Singh, UB</creatorcontrib><creatorcontrib>Mohapatra, S</creatorcontrib><creatorcontrib>Wagh, VK</creatorcontrib><creatorcontrib>Porwal, C</creatorcontrib><creatorcontrib>Kaushik, A</creatorcontrib><creatorcontrib>Rajpal</creatorcontrib><title>Association of mycobacterium tuberculosis in the causation of Eales’ disease: An institutional experience</title><title>Indian journal of medical microbiology</title><addtitle>Indian J Med Microbiol</addtitle><description>Background: Eales’ disease is an idiopathic retinal vasculitis characterized by retinal inflammation, ischemia, and neo-vascularisation. It frequently causes massive vitreous haemorrhage and retinal detachment leading to blindness. Although the exact etiology is unknown, this condition is considered to be a consequence of hypersensitivity reaction to tubercular protein due to previous Mycobacterium tuberculosis (M. tuberculosis) infection. This study is aimed at the detection of association of M. tuberculosis in patients with Eales’ disease. Materials and Methods: A prospective case-control study was undertaken in 65 clinically diagnosed cases of Eales’ disease. Patients with proliferative diabetic retinopathy, neo-vascular proliferation, macular oedema, premacular fibrosis and tractional retinal detachment were taken as controls. M. tuberculosis DNA was detected (MPT64 gene by polymerase chain reaction, PCR) in patients with Eales’ disease. Clinical symptoms along with tuberculin skin test (TST) and erythrocyte sedimentation rate (ESR) were used as gold standard for comparing results of PCR. Result: PCR positivity was found in 12 (38.7%) patients with Eales’ disease. The PCR positivity was significantly associated with the patients with high TST reading and high ESR values. Conclusion: Patients with a high TST reading and ESR value and a positive PCR in vitreous samples have a high likelihood of having M. tuberculosis as an etiology.</description><subject>Adult</subject><subject>Blood Sedimentation</subject><subject>Case-Control Studies</subject><subject>Deoxyribonucleic acid</subject><subject>Diabetic retinopathy</subject><subject>Disease</subject><subject>DNA</subject><subject>Eales’ disease</subject><subject>Humans</subject><subject>Hypotheses</subject><subject>Immunology</subject><subject>Infections</subject><subject>Laboratories</subject><subject>Molecular weight</subject><subject>Mycobacterium tuberculosis</subject><subject>Mycobacterium tuberculosis - genetics</subject><subject>Neovascularization, Pathologic - diagnosis</subject><subject>Neovascularization, Pathologic - microbiology</subject><subject>Pathogenesis</subject><subject>Polymerase Chain Reaction</subject><subject>retinal detachment</subject><subject>Retinal Vasculitis - diagnosis</subject><subject>Retinal Vasculitis - microbiology</subject><subject>Risk Factors</subject><subject>Tuberculosis</subject><subject>Tuberculosis - diagnosis</subject><subject>Tuberculosis - microbiology</subject><subject>vitreous haemorrhage</subject><subject>Young Adult</subject><issn>0255-0857</issn><issn>1998-3646</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2015</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>8G5</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><sourceid>GUQSH</sourceid><sourceid>M2O</sourceid><recordid>eNp1kD1PIzEQhq0TCAJHT4UsUS_nz41NFyG-JCQarra83lmdIYmDx4ug42_c3-OX4BAu3VXWeJ55NfMQcszZmeJM_mJC64YZPT3jyhhhf5AJt9Y0slXtDpls2_vkAPGR1VpZtUf2hW71lGs9IU8zxBSiLzEtaRro4i2kzocCOY4LWsYOchjnCSPSuKTlD9DgR9zil34O-PH-l_YRwSOc09myglhiGdeMn1N4XdUwWAb4SXYHP0c4-n4Pye-ry4eLm-bu_vr2YnbXBCVYaYQUYmil5X0fjGBSQ6t8YJz13HJdv7vB-CCYUVZKI9reqtCyDowHI20n5SE53eSucnoeAYt7TGOuu6Djra7JU8N5pdiGCjkhZhjcKseFz2-OM7e269b63Fqf29itIyffwWO3gH478E9nBc43ANTzXiJkh-Hr9D5mCMX1Kf4__RO8N4jX</recordid><startdate>20150201</startdate><enddate>20150201</enddate><creator>Rajpal</creator><creator>Singh, UB</creator><creator>Mohapatra, S</creator><creator>Wagh, VK</creator><creator>Porwal, C</creator><creator>Kaushik, A</creator><general>Elsevier B.V</general><general>Elsevier Limited</general><scope>6I.</scope><scope>AAFTH</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7QL</scope><scope>7T7</scope><scope>7U9</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8FD</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>8G5</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>C1K</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FR3</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>GUQSH</scope><scope>H94</scope><scope>K9.</scope><scope>M0S</scope><scope>M1P</scope><scope>M2O</scope><scope>M7N</scope><scope>MBDVC</scope><scope>P64</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>Q9U</scope></search><sort><creationdate>20150201</creationdate><title>Association of mycobacterium tuberculosis in the causation of Eales’ disease: An institutional experience</title><author>Rajpal ; Singh, UB ; Mohapatra, S ; Wagh, VK ; Porwal, C ; Kaushik, A</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c420t-2322f6391ddc82035e64ac010d191591dbf8ac2084933826d94c60be8ae839b33</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2015</creationdate><topic>Adult</topic><topic>Blood Sedimentation</topic><topic>Case-Control Studies</topic><topic>Deoxyribonucleic acid</topic><topic>Diabetic retinopathy</topic><topic>Disease</topic><topic>DNA</topic><topic>Eales’ disease</topic><topic>Humans</topic><topic>Hypotheses</topic><topic>Immunology</topic><topic>Infections</topic><topic>Laboratories</topic><topic>Molecular weight</topic><topic>Mycobacterium tuberculosis</topic><topic>Mycobacterium tuberculosis - genetics</topic><topic>Neovascularization, Pathologic - diagnosis</topic><topic>Neovascularization, Pathologic - microbiology</topic><topic>Pathogenesis</topic><topic>Polymerase Chain Reaction</topic><topic>retinal detachment</topic><topic>Retinal Vasculitis - diagnosis</topic><topic>Retinal Vasculitis - microbiology</topic><topic>Risk Factors</topic><topic>Tuberculosis</topic><topic>Tuberculosis - diagnosis</topic><topic>Tuberculosis - microbiology</topic><topic>vitreous haemorrhage</topic><topic>Young Adult</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Rajpal</creatorcontrib><creatorcontrib>Singh, UB</creatorcontrib><creatorcontrib>Mohapatra, S</creatorcontrib><creatorcontrib>Wagh, VK</creatorcontrib><creatorcontrib>Porwal, C</creatorcontrib><creatorcontrib>Kaushik, A</creatorcontrib><creatorcontrib>Rajpal</creatorcontrib><collection>ScienceDirect Open Access Titles</collection><collection>Elsevier:ScienceDirect:Open Access</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Bacteriology Abstracts (Microbiology B)</collection><collection>Industrial and Applied Microbiology Abstracts (Microbiology A)</collection><collection>Virology and AIDS Abstracts</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Technology Research Database</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>Research Library (Alumni Edition)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>ProQuest Central</collection><collection>Environmental Sciences and Pollution Management</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Engineering Research Database</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>Research Library Prep</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Research Library</collection><collection>Algology Mycology and Protozoology Abstracts (Microbiology C)</collection><collection>Research Library (Corporate)</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>Publicly Available Content Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>ProQuest Central Basic</collection><jtitle>Indian journal of medical microbiology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Rajpal</au><au>Singh, UB</au><au>Mohapatra, S</au><au>Wagh, VK</au><au>Porwal, C</au><au>Kaushik, A</au><aucorp>Rajpal</aucorp><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Association of mycobacterium tuberculosis in the causation of Eales’ disease: An institutional experience</atitle><jtitle>Indian journal of medical microbiology</jtitle><addtitle>Indian J Med Microbiol</addtitle><date>2015-02-01</date><risdate>2015</risdate><volume>33</volume><spage>S43</spage><epage>S45</epage><pages>S43-S45</pages><issn>0255-0857</issn><eissn>1998-3646</eissn><abstract>Background: Eales’ disease is an idiopathic retinal vasculitis characterized by retinal inflammation, ischemia, and neo-vascularisation. It frequently causes massive vitreous haemorrhage and retinal detachment leading to blindness. Although the exact etiology is unknown, this condition is considered to be a consequence of hypersensitivity reaction to tubercular protein due to previous Mycobacterium tuberculosis (M. tuberculosis) infection. This study is aimed at the detection of association of M. tuberculosis in patients with Eales’ disease. Materials and Methods: A prospective case-control study was undertaken in 65 clinically diagnosed cases of Eales’ disease. Patients with proliferative diabetic retinopathy, neo-vascular proliferation, macular oedema, premacular fibrosis and tractional retinal detachment were taken as controls. M. tuberculosis DNA was detected (MPT64 gene by polymerase chain reaction, PCR) in patients with Eales’ disease. Clinical symptoms along with tuberculin skin test (TST) and erythrocyte sedimentation rate (ESR) were used as gold standard for comparing results of PCR. Result: PCR positivity was found in 12 (38.7%) patients with Eales’ disease. The PCR positivity was significantly associated with the patients with high TST reading and high ESR values. Conclusion: Patients with a high TST reading and ESR value and a positive PCR in vitreous samples have a high likelihood of having M. tuberculosis as an etiology.</abstract><cop>India</cop><pub>Elsevier B.V</pub><pmid>25657155</pmid><doi>10.4103/0255-0857.148829</doi><oa>free_for_read</oa></addata></record> |
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| subjects | Adult Blood Sedimentation Case-Control Studies Deoxyribonucleic acid Diabetic retinopathy Disease DNA Eales’ disease Humans Hypotheses Immunology Infections Laboratories Molecular weight Mycobacterium tuberculosis Mycobacterium tuberculosis - genetics Neovascularization, Pathologic - diagnosis Neovascularization, Pathologic - microbiology Pathogenesis Polymerase Chain Reaction retinal detachment Retinal Vasculitis - diagnosis Retinal Vasculitis - microbiology Risk Factors Tuberculosis Tuberculosis - diagnosis Tuberculosis - microbiology vitreous haemorrhage Young Adult |
| title | Association of mycobacterium tuberculosis in the causation of Eales’ disease: An institutional experience |
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