Does Bosentan Protect Diabetic Brain Alterations in Rats? The Role of Endothelin‐1 in the Diabetic Brain

Diabetes mellitus (DM) is a major problem all over the world, affecting more people in recent years. Individuals with diabetes are more prone to disease than non‐diabetics, especially vascular complications. The aim of this study was to examine the roles of the endothelin (ET)‐1 in brain damage form...

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Veröffentlicht in:	Basic & clinical pharmacology & toxicology 2015-03, Vol.116 (3), p.236-243
Hauptverfasser:	Demir, Recep, Cadirci, Elif, Akpinar, Erol, Cayir, Yasemin, Atmaca, Hasan Tarik, Un, Harun, Kunak, Celalettin Semih, Yayla, Muhammed, Bayraktutan, Zafer, Demir, Ilknur
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antioxidants - metabolism Brain - drug effects Brain - pathology Diabetes Mellitus, Experimental - physiopathology Dose-Response Relationship, Drug Endothelin Receptor Antagonists - administration & dosage Endothelin Receptor Antagonists - pharmacology Endothelin-1 - metabolism Male Nitric Oxide Synthase Type II - metabolism Nitric Oxide Synthase Type III - metabolism Rats Rats, Wistar Streptozocin Sulfonamides - administration & dosage Sulfonamides - pharmacology
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