Elevated plasma [alpha]-defensins in patients with acute exacerbation of fibrotic interstitial pneumonia

Patients with fibrosing interstitial lung diseases can develop acute exacerbation (AE). The aetiology of AE remains obscure, but neutrophils might play a pivotal role in the pathogenesis. Neutrophils store azurophil granules containing defensins that are antimicrobial peptides that also function in...

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Veröffentlicht in:Respiratory medicine 2015-02, Vol.109 (2), p.265
Hauptverfasser: Sakamoto, Noriho, Ishimatsu, Yuji, Kakugawa, Tomoyuki, Yura, Hirokazu, Tomonaga, Masaomi, Harada, Tatsuhiko, Nakashima, Shota, Hara, Shintaro, Hara, Atsuko, Ishimoto, Hiroshi, Yatera, Kazuhiro, Mukae, Hiroshi, Kohno, Shigeru
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Sprache:eng
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