Impact of platelet transfusion on toxicity and mortality after hematopoietic progenitor cell transplantation
Background Thrombocytopenia occurs commonly after hematopoietic progenitor cell transplantation (HPCT) and is associated with potential morbidity and mortality. Few studies have examined the impact of platelet (PLT) transfusion on clinical outcomes in HPCT while optimal PLT transfusion strategies af...
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| Veröffentlicht in: | Transfusion (Philadelphia, Pa.) Pa.), 2015-02, Vol.55 (2), p.253-258 |
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| creator | Christou, Grace Kekre, Natasha Petrcich, William Tokessy, Melanie Neurath, Doris Giulivi, Antonio Saidenberg, Elianna McDiarmid, Sheryl Atkins, Harold Bence-Bruckler, Isabelle Bredeson, Christopher Huebsch, Lothar Sabloff, Mitchell Sheppard, Dawn Tay, Jason Tinmouth, Alan Allan, David S. |
| description | Background
Thrombocytopenia occurs commonly after hematopoietic progenitor cell transplantation (HPCT) and is associated with potential morbidity and mortality. Few studies have examined the impact of platelet (PLT) transfusion on clinical outcomes in HPCT while optimal PLT transfusion strategies after HSCT remain uncertain.
Study Design and Methods
A retrospective single‐center cohort study was conducted on 522 patients undergoing HPCT between January 2002 and December 2007. Associations between PLT transfusion events and clinical characteristics with transplant‐related outcomes were assessed using univariate and multivariate analysis.
Results
Mean number of PLT transfusion events before Day +60 posttransplant was 7.5 (95% confidence interval, 6.7‐8.4) with greater number of events after allogeneic compared with autologous HPCT (p |
| doi_str_mv | 10.1111/trf.12817 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_journals_1654936816</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>3589367691</sourcerecordid><originalsourceid>FETCH-LOGICAL-c4617-feda3349bb84b3d52dbad7bad36172c1ef3da2f1e1e2a026ce7b022464f53a03</originalsourceid><addsrcrecordid>eNp1kEtP3TAQRi3UCi6PBX-gstQVi4DHjvNYVggCEqKluhJLy0nGrWkSp7av4P57DAF2WGNZI585tj5CjoGdQlpn0ZtT4BWUO2QFUpQZr2v5hawYyyEDEHyP7IfwwBjjNYNdssclcMkquSLD9TjrLlJn6DzoiANGGr2egtkE6yaaKron29m4pXrq6eh81MNrZyJ6-hdHHd3sLEbb0dm7PzjZ6DztcBgWU_JOUcdkOyRfjR4CHr2dB2R9ebE-v8pufjbX5z9usi4voMwM9lqIvG7bKm9FL3nf6r5MW6Rb3gEa0WtuAAG5ZrzosGwZ53mRGyk0Ewfk-6JN3_m_wRDVg9v4Kb2ooJB5LYoKikSdLFTnXQgejZq9HbXfKmDqJVaVYlWvsSb225tx047Yf5DvOSbgbAEe7YDbz01q_fvyXZktEzZEfPqY0P6fKkpRSnV_26i7Ji_uflWNasQzghWTtg</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1654936816</pqid></control><display><type>article</type><title>Impact of platelet transfusion on toxicity and mortality after hematopoietic progenitor cell transplantation</title><source>MEDLINE</source><source>Wiley Online Library Journals Frontfile Complete</source><creator>Christou, Grace ; Kekre, Natasha ; Petrcich, William ; Tokessy, Melanie ; Neurath, Doris ; Giulivi, Antonio ; Saidenberg, Elianna ; McDiarmid, Sheryl ; Atkins, Harold ; Bence-Bruckler, Isabelle ; Bredeson, Christopher ; Huebsch, Lothar ; Sabloff, Mitchell ; Sheppard, Dawn ; Tay, Jason ; Tinmouth, Alan ; Allan, David S.</creator><creatorcontrib>Christou, Grace ; Kekre, Natasha ; Petrcich, William ; Tokessy, Melanie ; Neurath, Doris ; Giulivi, Antonio ; Saidenberg, Elianna ; McDiarmid, Sheryl ; Atkins, Harold ; Bence-Bruckler, Isabelle ; Bredeson, Christopher ; Huebsch, Lothar ; Sabloff, Mitchell ; Sheppard, Dawn ; Tay, Jason ; Tinmouth, Alan ; Allan, David S.</creatorcontrib><description>Background
Thrombocytopenia occurs commonly after hematopoietic progenitor cell transplantation (HPCT) and is associated with potential morbidity and mortality. Few studies have examined the impact of platelet (PLT) transfusion on clinical outcomes in HPCT while optimal PLT transfusion strategies after HSCT remain uncertain.
Study Design and Methods
A retrospective single‐center cohort study was conducted on 522 patients undergoing HPCT between January 2002 and December 2007. Associations between PLT transfusion events and clinical characteristics with transplant‐related outcomes were assessed using univariate and multivariate analysis.
Results
Mean number of PLT transfusion events before Day +60 posttransplant was 7.5 (95% confidence interval, 6.7‐8.4) with greater number of events after allogeneic compared with autologous HPCT (p < 0.01). Univariate and multivariate analysis confirmed that the number of PLT transfusion events was associated with increased 100‐day nonrelapse mortality (p < 0.01), posttransplant length of hospital stay (p < 0.01), need for intensive care unit admission (p < 0.01), and number of organs affected by severe toxicity (p < 0.01).
Conclusion
HPCT‐related toxicity and mortality are associated with increased PLT transfusion events. Alternative strategies to reduce PLT transfusions after HPCT may warrant future study.</description><identifier>ISSN: 0041-1132</identifier><identifier>EISSN: 1537-2995</identifier><identifier>DOI: 10.1111/trf.12817</identifier><identifier>PMID: 25125085</identifier><identifier>CODEN: TRANAT</identifier><language>eng</language><publisher>United States: Blackwell Publishing Ltd</publisher><subject>Adult ; Allografts ; Confidence intervals ; Disease-Free Survival ; Female ; Follow-Up Studies ; Health risk assessment ; Hematologic Neoplasms - mortality ; Hematologic Neoplasms - therapy ; Hematopoietic Stem Cell Transplantation ; Humans ; Male ; Middle Aged ; Mortality ; Platelet Transfusion - mortality ; Survival Rate ; Thrombocytopenia - etiology ; Thrombocytopenia - mortality ; Time Factors ; Toxicity ; Transplants & implants</subject><ispartof>Transfusion (Philadelphia, Pa.), 2015-02, Vol.55 (2), p.253-258</ispartof><rights>2014 AABB</rights><rights>2014 AABB.</rights><rights>2015 AABB</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4617-feda3349bb84b3d52dbad7bad36172c1ef3da2f1e1e2a026ce7b022464f53a03</citedby><cites>FETCH-LOGICAL-c4617-feda3349bb84b3d52dbad7bad36172c1ef3da2f1e1e2a026ce7b022464f53a03</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1111%2Ftrf.12817$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1111%2Ftrf.12817$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,780,784,1416,27923,27924,45573,45574</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/25125085$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Christou, Grace</creatorcontrib><creatorcontrib>Kekre, Natasha</creatorcontrib><creatorcontrib>Petrcich, William</creatorcontrib><creatorcontrib>Tokessy, Melanie</creatorcontrib><creatorcontrib>Neurath, Doris</creatorcontrib><creatorcontrib>Giulivi, Antonio</creatorcontrib><creatorcontrib>Saidenberg, Elianna</creatorcontrib><creatorcontrib>McDiarmid, Sheryl</creatorcontrib><creatorcontrib>Atkins, Harold</creatorcontrib><creatorcontrib>Bence-Bruckler, Isabelle</creatorcontrib><creatorcontrib>Bredeson, Christopher</creatorcontrib><creatorcontrib>Huebsch, Lothar</creatorcontrib><creatorcontrib>Sabloff, Mitchell</creatorcontrib><creatorcontrib>Sheppard, Dawn</creatorcontrib><creatorcontrib>Tay, Jason</creatorcontrib><creatorcontrib>Tinmouth, Alan</creatorcontrib><creatorcontrib>Allan, David S.</creatorcontrib><title>Impact of platelet transfusion on toxicity and mortality after hematopoietic progenitor cell transplantation</title><title>Transfusion (Philadelphia, Pa.)</title><addtitle>Transfusion</addtitle><description>Background
Thrombocytopenia occurs commonly after hematopoietic progenitor cell transplantation (HPCT) and is associated with potential morbidity and mortality. Few studies have examined the impact of platelet (PLT) transfusion on clinical outcomes in HPCT while optimal PLT transfusion strategies after HSCT remain uncertain.
Study Design and Methods
A retrospective single‐center cohort study was conducted on 522 patients undergoing HPCT between January 2002 and December 2007. Associations between PLT transfusion events and clinical characteristics with transplant‐related outcomes were assessed using univariate and multivariate analysis.
Results
Mean number of PLT transfusion events before Day +60 posttransplant was 7.5 (95% confidence interval, 6.7‐8.4) with greater number of events after allogeneic compared with autologous HPCT (p < 0.01). Univariate and multivariate analysis confirmed that the number of PLT transfusion events was associated with increased 100‐day nonrelapse mortality (p < 0.01), posttransplant length of hospital stay (p < 0.01), need for intensive care unit admission (p < 0.01), and number of organs affected by severe toxicity (p < 0.01).
Conclusion
HPCT‐related toxicity and mortality are associated with increased PLT transfusion events. Alternative strategies to reduce PLT transfusions after HPCT may warrant future study.</description><subject>Adult</subject><subject>Allografts</subject><subject>Confidence intervals</subject><subject>Disease-Free Survival</subject><subject>Female</subject><subject>Follow-Up Studies</subject><subject>Health risk assessment</subject><subject>Hematologic Neoplasms - mortality</subject><subject>Hematologic Neoplasms - therapy</subject><subject>Hematopoietic Stem Cell Transplantation</subject><subject>Humans</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Mortality</subject><subject>Platelet Transfusion - mortality</subject><subject>Survival Rate</subject><subject>Thrombocytopenia - etiology</subject><subject>Thrombocytopenia - mortality</subject><subject>Time Factors</subject><subject>Toxicity</subject><subject>Transplants & implants</subject><issn>0041-1132</issn><issn>1537-2995</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2015</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp1kEtP3TAQRi3UCi6PBX-gstQVi4DHjvNYVggCEqKluhJLy0nGrWkSp7av4P57DAF2WGNZI585tj5CjoGdQlpn0ZtT4BWUO2QFUpQZr2v5hawYyyEDEHyP7IfwwBjjNYNdssclcMkquSLD9TjrLlJn6DzoiANGGr2egtkE6yaaKron29m4pXrq6eh81MNrZyJ6-hdHHd3sLEbb0dm7PzjZ6DztcBgWU_JOUcdkOyRfjR4CHr2dB2R9ebE-v8pufjbX5z9usi4voMwM9lqIvG7bKm9FL3nf6r5MW6Rb3gEa0WtuAAG5ZrzosGwZ53mRGyk0Ewfk-6JN3_m_wRDVg9v4Kb2ooJB5LYoKikSdLFTnXQgejZq9HbXfKmDqJVaVYlWvsSb225tx047Yf5DvOSbgbAEe7YDbz01q_fvyXZktEzZEfPqY0P6fKkpRSnV_26i7Ji_uflWNasQzghWTtg</recordid><startdate>201502</startdate><enddate>201502</enddate><creator>Christou, Grace</creator><creator>Kekre, Natasha</creator><creator>Petrcich, William</creator><creator>Tokessy, Melanie</creator><creator>Neurath, Doris</creator><creator>Giulivi, Antonio</creator><creator>Saidenberg, Elianna</creator><creator>McDiarmid, Sheryl</creator><creator>Atkins, Harold</creator><creator>Bence-Bruckler, Isabelle</creator><creator>Bredeson, Christopher</creator><creator>Huebsch, Lothar</creator><creator>Sabloff, Mitchell</creator><creator>Sheppard, Dawn</creator><creator>Tay, Jason</creator><creator>Tinmouth, Alan</creator><creator>Allan, David S.</creator><general>Blackwell Publishing Ltd</general><general>Wiley Subscription Services, Inc</general><scope>BSCLL</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QO</scope><scope>7U9</scope><scope>8FD</scope><scope>FR3</scope><scope>H94</scope><scope>K9.</scope><scope>P64</scope></search><sort><creationdate>201502</creationdate><title>Impact of platelet transfusion on toxicity and mortality after hematopoietic progenitor cell transplantation</title><author>Christou, Grace ; Kekre, Natasha ; Petrcich, William ; Tokessy, Melanie ; Neurath, Doris ; Giulivi, Antonio ; Saidenberg, Elianna ; McDiarmid, Sheryl ; Atkins, Harold ; Bence-Bruckler, Isabelle ; Bredeson, Christopher ; Huebsch, Lothar ; Sabloff, Mitchell ; Sheppard, Dawn ; Tay, Jason ; Tinmouth, Alan ; Allan, David S.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4617-feda3349bb84b3d52dbad7bad36172c1ef3da2f1e1e2a026ce7b022464f53a03</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2015</creationdate><topic>Adult</topic><topic>Allografts</topic><topic>Confidence intervals</topic><topic>Disease-Free Survival</topic><topic>Female</topic><topic>Follow-Up Studies</topic><topic>Health risk assessment</topic><topic>Hematologic Neoplasms - mortality</topic><topic>Hematologic Neoplasms - therapy</topic><topic>Hematopoietic Stem Cell Transplantation</topic><topic>Humans</topic><topic>Male</topic><topic>Middle Aged</topic><topic>Mortality</topic><topic>Platelet Transfusion - mortality</topic><topic>Survival Rate</topic><topic>Thrombocytopenia - etiology</topic><topic>Thrombocytopenia - mortality</topic><topic>Time Factors</topic><topic>Toxicity</topic><topic>Transplants & implants</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Christou, Grace</creatorcontrib><creatorcontrib>Kekre, Natasha</creatorcontrib><creatorcontrib>Petrcich, William</creatorcontrib><creatorcontrib>Tokessy, Melanie</creatorcontrib><creatorcontrib>Neurath, Doris</creatorcontrib><creatorcontrib>Giulivi, Antonio</creatorcontrib><creatorcontrib>Saidenberg, Elianna</creatorcontrib><creatorcontrib>McDiarmid, Sheryl</creatorcontrib><creatorcontrib>Atkins, Harold</creatorcontrib><creatorcontrib>Bence-Bruckler, Isabelle</creatorcontrib><creatorcontrib>Bredeson, Christopher</creatorcontrib><creatorcontrib>Huebsch, Lothar</creatorcontrib><creatorcontrib>Sabloff, Mitchell</creatorcontrib><creatorcontrib>Sheppard, Dawn</creatorcontrib><creatorcontrib>Tay, Jason</creatorcontrib><creatorcontrib>Tinmouth, Alan</creatorcontrib><creatorcontrib>Allan, David S.</creatorcontrib><collection>Istex</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Biotechnology Research Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>Technology Research Database</collection><collection>Engineering Research Database</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Biotechnology and BioEngineering Abstracts</collection><jtitle>Transfusion (Philadelphia, Pa.)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Christou, Grace</au><au>Kekre, Natasha</au><au>Petrcich, William</au><au>Tokessy, Melanie</au><au>Neurath, Doris</au><au>Giulivi, Antonio</au><au>Saidenberg, Elianna</au><au>McDiarmid, Sheryl</au><au>Atkins, Harold</au><au>Bence-Bruckler, Isabelle</au><au>Bredeson, Christopher</au><au>Huebsch, Lothar</au><au>Sabloff, Mitchell</au><au>Sheppard, Dawn</au><au>Tay, Jason</au><au>Tinmouth, Alan</au><au>Allan, David S.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Impact of platelet transfusion on toxicity and mortality after hematopoietic progenitor cell transplantation</atitle><jtitle>Transfusion (Philadelphia, Pa.)</jtitle><addtitle>Transfusion</addtitle><date>2015-02</date><risdate>2015</risdate><volume>55</volume><issue>2</issue><spage>253</spage><epage>258</epage><pages>253-258</pages><issn>0041-1132</issn><eissn>1537-2995</eissn><coden>TRANAT</coden><abstract>Background
Thrombocytopenia occurs commonly after hematopoietic progenitor cell transplantation (HPCT) and is associated with potential morbidity and mortality. Few studies have examined the impact of platelet (PLT) transfusion on clinical outcomes in HPCT while optimal PLT transfusion strategies after HSCT remain uncertain.
Study Design and Methods
A retrospective single‐center cohort study was conducted on 522 patients undergoing HPCT between January 2002 and December 2007. Associations between PLT transfusion events and clinical characteristics with transplant‐related outcomes were assessed using univariate and multivariate analysis.
Results
Mean number of PLT transfusion events before Day +60 posttransplant was 7.5 (95% confidence interval, 6.7‐8.4) with greater number of events after allogeneic compared with autologous HPCT (p < 0.01). Univariate and multivariate analysis confirmed that the number of PLT transfusion events was associated with increased 100‐day nonrelapse mortality (p < 0.01), posttransplant length of hospital stay (p < 0.01), need for intensive care unit admission (p < 0.01), and number of organs affected by severe toxicity (p < 0.01).
Conclusion
HPCT‐related toxicity and mortality are associated with increased PLT transfusion events. Alternative strategies to reduce PLT transfusions after HPCT may warrant future study.</abstract><cop>United States</cop><pub>Blackwell Publishing Ltd</pub><pmid>25125085</pmid><doi>10.1111/trf.12817</doi><tpages>6</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0041-1132 |
| ispartof | Transfusion (Philadelphia, Pa.), 2015-02, Vol.55 (2), p.253-258 |
| issn | 0041-1132 1537-2995 |
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| source | MEDLINE; Wiley Online Library Journals Frontfile Complete |
| subjects | Adult Allografts Confidence intervals Disease-Free Survival Female Follow-Up Studies Health risk assessment Hematologic Neoplasms - mortality Hematologic Neoplasms - therapy Hematopoietic Stem Cell Transplantation Humans Male Middle Aged Mortality Platelet Transfusion - mortality Survival Rate Thrombocytopenia - etiology Thrombocytopenia - mortality Time Factors Toxicity Transplants & implants |
| title | Impact of platelet transfusion on toxicity and mortality after hematopoietic progenitor cell transplantation |
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