The effect of acute morphine on delay discounting in dependent and non-dependent rats
Rationale Chronic opiate use is associated with increased impulsivity in both humans and animals, and previous studies suggest that acute morphine can increase impulsivity in non-dependent rats. However, the extent to which chronic opiate usage modulates the effect of acute morphine is unknown. Meth...
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| Veröffentlicht in: | Psychopharmacology 2015-03, Vol.232 (5), p.885-895 |
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| creator | Harvey-Lewis, Colin Franklin, Keith B. J. |
| description | Rationale
Chronic opiate use is associated with increased impulsivity in both humans and animals, and previous studies suggest that acute morphine can increase impulsivity in non-dependent rats. However, the extent to which chronic opiate usage modulates the effect of acute morphine is unknown.
Methods
Rats were trained to delay discount 20 % sucrose solution and then randomly assigned to either a dependent group that received a nightly 30 mg/kg subcutaneous dose of morphine or a non-dependent group that received a nightly saline injection. Once dependence was established, rats were then assigned to one of four acute morphine doses (0, 1.25, 2.5, 5 mg/kg). For 5 days, delay discounting curves were determined 22.5 h after maintenance doses and 1 h after their prescribed acute injections.
Results
In non-dependent rats, 2.5 and 5 mg/kg doses of morphine caused decreased preference for the large reward at all delays. Acute morphine had no effect on discounting curves in dependent rats.
Conclusions
Morphine dependence can cause tolerance to the effects of acute morphine on delay discounting. |
| doi_str_mv | 10.1007/s00213-014-3724-x |
| format | Article |
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Chronic opiate use is associated with increased impulsivity in both humans and animals, and previous studies suggest that acute morphine can increase impulsivity in non-dependent rats. However, the extent to which chronic opiate usage modulates the effect of acute morphine is unknown.
Methods
Rats were trained to delay discount 20 % sucrose solution and then randomly assigned to either a dependent group that received a nightly 30 mg/kg subcutaneous dose of morphine or a non-dependent group that received a nightly saline injection. Once dependence was established, rats were then assigned to one of four acute morphine doses (0, 1.25, 2.5, 5 mg/kg). For 5 days, delay discounting curves were determined 22.5 h after maintenance doses and 1 h after their prescribed acute injections.
Results
In non-dependent rats, 2.5 and 5 mg/kg doses of morphine caused decreased preference for the large reward at all delays. Acute morphine had no effect on discounting curves in dependent rats.
Conclusions
Morphine dependence can cause tolerance to the effects of acute morphine on delay discounting.</description><identifier>ISSN: 0033-3158</identifier><identifier>EISSN: 1432-2072</identifier><identifier>DOI: 10.1007/s00213-014-3724-x</identifier><identifier>PMID: 25189791</identifier><language>eng</language><publisher>Berlin/Heidelberg: Springer Berlin Heidelberg</publisher><subject>Analgesics, Opioid - pharmacology ; Animals ; Biomedical and Life Sciences ; Biomedicine ; Care and treatment ; Complications and side effects ; Delay Discounting ; Diagnosis ; Dosage and administration ; Dose-Response Relationship, Drug ; Drug abuse ; Drug addiction ; Impulsive Behavior - drug effects ; Laboratory rats ; Male ; Morphine ; Morphine - pharmacology ; Morphine Dependence - psychology ; Narcotics ; Neurosciences ; Original Investigation ; Pharmacology/Toxicology ; Psychiatry ; Psychopharmacology ; Rats ; Reward ; Risk factors ; Rodents ; Sucrose - administration & dosage</subject><ispartof>Psychopharmacology, 2015-03, Vol.232 (5), p.885-895</ispartof><rights>Springer-Verlag Berlin Heidelberg 2014</rights><rights>COPYRIGHT 2015 Springer</rights><rights>Springer-Verlag Berlin Heidelberg 2015</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c439t-9dea0d82101602a17ee7a7547e00b40e2a04fa284144ba8df520c5c6cc1fe9ec3</citedby><cites>FETCH-LOGICAL-c439t-9dea0d82101602a17ee7a7547e00b40e2a04fa284144ba8df520c5c6cc1fe9ec3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s00213-014-3724-x$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s00213-014-3724-x$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,780,784,27924,27925,41488,42557,51319</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/25189791$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Harvey-Lewis, Colin</creatorcontrib><creatorcontrib>Franklin, Keith B. J.</creatorcontrib><title>The effect of acute morphine on delay discounting in dependent and non-dependent rats</title><title>Psychopharmacology</title><addtitle>Psychopharmacology</addtitle><addtitle>Psychopharmacology (Berl)</addtitle><description>Rationale
Chronic opiate use is associated with increased impulsivity in both humans and animals, and previous studies suggest that acute morphine can increase impulsivity in non-dependent rats. However, the extent to which chronic opiate usage modulates the effect of acute morphine is unknown.
Methods
Rats were trained to delay discount 20 % sucrose solution and then randomly assigned to either a dependent group that received a nightly 30 mg/kg subcutaneous dose of morphine or a non-dependent group that received a nightly saline injection. Once dependence was established, rats were then assigned to one of four acute morphine doses (0, 1.25, 2.5, 5 mg/kg). For 5 days, delay discounting curves were determined 22.5 h after maintenance doses and 1 h after their prescribed acute injections.
Results
In non-dependent rats, 2.5 and 5 mg/kg doses of morphine caused decreased preference for the large reward at all delays. Acute morphine had no effect on discounting curves in dependent rats.
Conclusions
Morphine dependence can cause tolerance to the effects of acute morphine on delay discounting.</description><subject>Analgesics, Opioid - pharmacology</subject><subject>Animals</subject><subject>Biomedical and Life Sciences</subject><subject>Biomedicine</subject><subject>Care and treatment</subject><subject>Complications and side effects</subject><subject>Delay Discounting</subject><subject>Diagnosis</subject><subject>Dosage and administration</subject><subject>Dose-Response Relationship, Drug</subject><subject>Drug abuse</subject><subject>Drug addiction</subject><subject>Impulsive Behavior - drug effects</subject><subject>Laboratory rats</subject><subject>Male</subject><subject>Morphine</subject><subject>Morphine - pharmacology</subject><subject>Morphine Dependence - psychology</subject><subject>Narcotics</subject><subject>Neurosciences</subject><subject>Original Investigation</subject><subject>Pharmacology/Toxicology</subject><subject>Psychiatry</subject><subject>Psychopharmacology</subject><subject>Rats</subject><subject>Reward</subject><subject>Risk factors</subject><subject>Rodents</subject><subject>Sucrose - administration & dosage</subject><issn>0033-3158</issn><issn>1432-2072</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2015</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><recordid>eNp1kU9LJDEQxYOs6OjuB9jLEthztPKnO91HEd0VBC96DpmkMrZMJ2PSDfrtzTDuqqCpQ-DVe5UUP0J-cjjhAPq0AAguGXDFpBaKPe2RBVdSMAFafCMLACmZ5E13SI5KeYB6VKcOyKFoeNfrni_I3e09UgwB3URToNbNE9Ix5c39EJGmSD2u7TP1Q3FpjtMQV3TYihuMHuNEbfQ0psjelGyn8p3sB7su-OP1PiZ3lxe353_Z9c2fq_Oza-aU7CfWe7TgO8GBtyAs14ja6kZpBFgqQGFBBSs6xZVa2s6HRoBrXOscD9ijk8fk927uJqfHGctkHtKcY33S8LZRjZa6bd9cK7tGM8SQpmzdWFcyZwq6nrdKd9V18omrlsdxcCliGKr-IcB3AZdTKRmD2eRhtPnZcDBbPmbHx1Q-ZsvHPNXMr9cPz8sR_f_EPyDVIHaGUltxhfndRl9OfQFCsZmo</recordid><startdate>20150301</startdate><enddate>20150301</enddate><creator>Harvey-Lewis, Colin</creator><creator>Franklin, Keith B. 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J.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c439t-9dea0d82101602a17ee7a7547e00b40e2a04fa284144ba8df520c5c6cc1fe9ec3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2015</creationdate><topic>Analgesics, Opioid - pharmacology</topic><topic>Animals</topic><topic>Biomedical and Life Sciences</topic><topic>Biomedicine</topic><topic>Care and treatment</topic><topic>Complications and side effects</topic><topic>Delay Discounting</topic><topic>Diagnosis</topic><topic>Dosage and administration</topic><topic>Dose-Response Relationship, Drug</topic><topic>Drug abuse</topic><topic>Drug addiction</topic><topic>Impulsive Behavior - drug effects</topic><topic>Laboratory rats</topic><topic>Male</topic><topic>Morphine</topic><topic>Morphine - pharmacology</topic><topic>Morphine Dependence - psychology</topic><topic>Narcotics</topic><topic>Neurosciences</topic><topic>Original Investigation</topic><topic>Pharmacology/Toxicology</topic><topic>Psychiatry</topic><topic>Psychopharmacology</topic><topic>Rats</topic><topic>Reward</topic><topic>Risk factors</topic><topic>Rodents</topic><topic>Sucrose - administration & dosage</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Harvey-Lewis, Colin</creatorcontrib><creatorcontrib>Franklin, Keith B. J.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Animal Behavior Abstracts</collection><collection>Chemoreception Abstracts</collection><collection>Proquest Nursing & Allied Health Source</collection><collection>Neurosciences Abstracts</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Psychology Database (Alumni)</collection><collection>ProQuest Pharma Collection</collection><collection>Technology Research Database</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Engineering Research Database</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Database (Alumni Edition)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Psychology Database (ProQuest)</collection><collection>Nursing & Allied Health Premium</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>ProQuest One Psychology</collection><collection>ProQuest Central Basic</collection><jtitle>Psychopharmacology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Harvey-Lewis, Colin</au><au>Franklin, Keith B. J.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>The effect of acute morphine on delay discounting in dependent and non-dependent rats</atitle><jtitle>Psychopharmacology</jtitle><stitle>Psychopharmacology</stitle><addtitle>Psychopharmacology (Berl)</addtitle><date>2015-03-01</date><risdate>2015</risdate><volume>232</volume><issue>5</issue><spage>885</spage><epage>895</epage><pages>885-895</pages><issn>0033-3158</issn><eissn>1432-2072</eissn><abstract>Rationale
Chronic opiate use is associated with increased impulsivity in both humans and animals, and previous studies suggest that acute morphine can increase impulsivity in non-dependent rats. However, the extent to which chronic opiate usage modulates the effect of acute morphine is unknown.
Methods
Rats were trained to delay discount 20 % sucrose solution and then randomly assigned to either a dependent group that received a nightly 30 mg/kg subcutaneous dose of morphine or a non-dependent group that received a nightly saline injection. Once dependence was established, rats were then assigned to one of four acute morphine doses (0, 1.25, 2.5, 5 mg/kg). For 5 days, delay discounting curves were determined 22.5 h after maintenance doses and 1 h after their prescribed acute injections.
Results
In non-dependent rats, 2.5 and 5 mg/kg doses of morphine caused decreased preference for the large reward at all delays. Acute morphine had no effect on discounting curves in dependent rats.
Conclusions
Morphine dependence can cause tolerance to the effects of acute morphine on delay discounting.</abstract><cop>Berlin/Heidelberg</cop><pub>Springer Berlin Heidelberg</pub><pmid>25189791</pmid><doi>10.1007/s00213-014-3724-x</doi><tpages>11</tpages></addata></record> |
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| subjects | Analgesics, Opioid - pharmacology Animals Biomedical and Life Sciences Biomedicine Care and treatment Complications and side effects Delay Discounting Diagnosis Dosage and administration Dose-Response Relationship, Drug Drug abuse Drug addiction Impulsive Behavior - drug effects Laboratory rats Male Morphine Morphine - pharmacology Morphine Dependence - psychology Narcotics Neurosciences Original Investigation Pharmacology/Toxicology Psychiatry Psychopharmacology Rats Reward Risk factors Rodents Sucrose - administration & dosage |
| title | The effect of acute morphine on delay discounting in dependent and non-dependent rats |
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